Zobrazeno 1 - 10
of 597
pro vyhledávání: '"Abdu I"'
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Introduction: Electrostatic binding of deoxyhemoglobin (Hb) to cytoplasmic domain of band 3 anion transport protein occurs as part of the glycolytic regulation in red blood cells (RBCs). Hb oxidation intermediates not only impact RBC’s oxygenation
Externí odkaz:
https://doaj.org/article/a2e91ea9b5014c82b05557798fad4718
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Red blood cells (RBCs) undergo metabolic, oxidative, and physiological changes during storage, collectively described as the “storage lesion.” The impact of storage on oxygen homeostasis, following transfusion, is not fully understood. We show th
Externí odkaz:
https://doaj.org/article/d406247457614ef7b75f0f060bf22937
Publikováno v:
FEBS Open Bio, Vol 11, Iss 12, Pp 3293-3303 (2021)
It is well documented that caffeic acid (3,4‐dihydroxycinnamic acid) (CA) interacts with and inhibits the oxidative reactions of myoglobin (Mb) and hemoglobin (Hb), and this interaction underlies its antioxidative action in meat. Sickle cell hemogl
Externí odkaz:
https://doaj.org/article/9b339d0f101547138ceaf5690cc514db
Autor:
Abdu I. Alayash
Publikováno v:
Frontiers in Medical Technology, Vol 4 (2022)
Oxygen reversibly binds to the redox active iron, a transition metal in human Hemoglobin (Hb), which subsequently undergoes oxidation in air. This process is akin to iron rusting in non-biological systems. This results in the formation of non-oxygen
Externí odkaz:
https://doaj.org/article/ee268be5ffbb410181d5d1813d96b92f
Autor:
Abdu I. Alayash, Michael T. Wilson
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/f928ee1cb75b4dd6ad641ef059d93873
Publikováno v:
Redox Report, Vol 25, Iss 1, Pp 95-103 (2020)
The β subunit substitutions, F41Y and K82D, in sickle cell hemoglobin (Hb) (βE6 V) provides significant resistance to oxidative stress by shielding βCys93 from the oxidizing ferryl heme. We evaluated the oxidative resistance of βCys93 to hydrogen
Externí odkaz:
https://doaj.org/article/b29b1e68b2e04a4587a062e013d891e0
Autor:
Sirsendu Jana, Michael R. Heaven, Charles B. Stauft, Tony T. Wang, Matthew C. Williams, Felice D’Agnillo, Abdu I. Alayash
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 558 (2022)
The mechanistic interplay between SARS-CoV-2 infection, inflammation, and oxygen homeostasis is not well defined. Here, we show that the hypoxia-inducible factor (HIF-1α) transcriptional pathway is activated, perhaps due to a lack of oxygen or an ac
Externí odkaz:
https://doaj.org/article/fa9727b72efc4c5ab7e4fa4e4a6d1f43
Autor:
Abdu I. Alayash
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
The novel coronavirus (2019-nCoV/SARS-CoV-2) causes respiratory symptoms including a substantial pulmonary dysfunction with worsening arterial hypoxemia (low blood oxygenation), eventually leading to acute respiratory distress syndrome (ARDS). The im
Externí odkaz:
https://doaj.org/article/9ff5ed90a0e14067b5eae72e24fca992
Autor:
Abdu I. Alayash
Publikováno v:
Haematologica, Vol 106, Iss 1 (2021)
Externí odkaz:
https://doaj.org/article/0e73d04b6c9f4d399b1952a10a1322fe
Autor:
Abdu I. Alayash
Publikováno v:
Antioxidants, Vol 11, Iss 4, p 747 (2022)
Hemoglobin (Hb) inside and outside the red blood cells (RBCs) undergoes constant transformation to an oxidized form in a process known as autoxidation. The ferrous heme iron (Fe2+) of the prosthetic group is spontaneously transformed into an oxidized
Externí odkaz:
https://doaj.org/article/9e1b8925ac3b4de4804b89a204b2e51f