Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Abdoulaye Sene"'
Autor:
Martin Weber, Sang-Won Min, Tom Truong, Jeffrey Hung, Stephanie Dale, Mike Reichelt, Savita Ubhayakar, Carol Cain-Hom, Miriam Baca, Zhiyu Jiang, Qingling Li, Robert Brendza, Han Lin, Chung Kung, William F. Forrest, Cristine Quiason-Huynh, Wendy Sandoval, Buyun Chen, Yuzhong Deng, Amy Easton, Oded Foreman, Abdoulaye Sene, Baris Bingol
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Mutations in the GBA1 gene encoding glucocerebrosidase (GCase) are linked to Gaucher (GD) and Parkinson’s Disease (PD). Since some GD and PD patients develop ocular phenotypes, we determined whether ocular phenotypes might result from impa
Externí odkaz:
https://doaj.org/article/08dc67cbf02f4f9ab4c713dcac4d0867
Autor:
Andrea Santeford, Aaron Y Lee, Abdoulaye Sene, Lynn M Hassman, Alexey A Sergushichev, Ekaterina Loginicheva, Maxim N Artyomov, Philip A Ruzycki, Rajendra S Apte
Publikováno v:
eLife, Vol 10 (2021)
Macrophages undergo programmatic changes with age, leading to altered cytokine polarization and immune dysfunction, shifting these critical immune cells from protective sentinels to disease promoters. The molecular mechanisms underlying macrophage in
Externí odkaz:
https://doaj.org/article/6fb8d853a91b4d1da48547761a3b3cc2
Autor:
Yo Sasaki, Hiroki Kakita, Shunsuke Kubota, Abdoulaye Sene, Tae Jun Lee, Norimitsu Ban, Zhenyu Dong, Joseph B Lin, Sanford L Boye, Aaron DiAntonio, Shannon E Boye, Rajendra S Apte, Jeffrey Milbrandt
Publikováno v:
eLife, Vol 9 (2020)
Leber congenital amaurosis type nine is an autosomal recessive retinopathy caused by mutations of the NAD+ synthesis enzyme NMNAT1. Despite the ubiquitous expression of NMNAT1, patients do not manifest pathologies other than retinal degeneration. Her
Externí odkaz:
https://doaj.org/article/4275e0ca179049eabb78a4c6222a8885
Autor:
Norimitsu Ban, Tae Jun Lee, Abdoulaye Sene, Zhenyu Dong, Andrea Santeford, Jonathan B. Lin, Daniel S. Ory, Rajendra S. Apte
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 8, Pp 1414-1423 (2018)
Photoreceptors have high intrinsic metabolic demand and are exquisitely sensitive to metabolic perturbation. In addition, they shed a large portion of their outer segment lipid membranes in a circadian manner, increasing the metabolic burden on the o
Externí odkaz:
https://doaj.org/article/f37d5b70129147069a9c4ae9a8dbc85e
Autor:
Jonathan B. Lin, Abdoulaye Sene, Andrea Santeford, Hideji Fujiwara, Rohini Sidhu, Marianne M. Ligon, Vikram A. Shankar, Norimitsu Ban, Indira U. Mysorekar, Daniel S. Ory, Rajendra S. Apte
Publikováno v:
EBioMedicine, Vol 32, Iss , Pp 9-20 (2018)
Macrophage aging is pathogenic in numerous diseases, including age-related macular degeneration (AMD), a leading cause of blindness in older adults. Although prior studies have explored the functional consequences of macrophage aging, less is known a
Externí odkaz:
https://doaj.org/article/affa62f8204a49bdbf413e70b5b10010
Autor:
Jonathan J. Miner, Abdoulaye Sene, Justin M. Richner, Amber M. Smith, Andrea Santeford, Norimitsu Ban, James Weger-Lucarelli, Francesca Manzella, Claudia Rückert, Jennifer Govero, Kevin K. Noguchi, Gregory D. Ebel, Michael S. Diamond, Rajendra S. Apte
Publikováno v:
Cell Reports, Vol 16, Iss 12, Pp 3208-3218 (2016)
Zika virus (ZIKV) is an emerging flavivirus that causes congenital abnormalities and Guillain-Barré syndrome. ZIKV infection also results in severe eye disease characterized by optic neuritis, chorioretinal atrophy, and blindness in newborns and con
Externí odkaz:
https://doaj.org/article/766a998ca629426fbdb33df443eb65d9
Autor:
Jonathan B. Lin, Shunsuke Kubota, Norimitsu Ban, Mitsukuni Yoshida, Andrea Santeford, Abdoulaye Sene, Rei Nakamura, Nicole Zapata, Miyuki Kubota, Kazuo Tsubota, Jun Yoshino, Shin-ichiro Imai, Rajendra S. Apte
Publikováno v:
Cell Reports, Vol 17, Iss 1, Pp 69-85 (2016)
Photoreceptor death is the endpoint of many blinding diseases. Identifying unifying pathogenic mechanisms in these diseases may offer global approaches for facilitating photoreceptor survival. We found that rod or cone photoreceptor-specific deletion
Externí odkaz:
https://doaj.org/article/ad5b3619cf5149aa8ea7fff5633aedfd
Autor:
Fernando Cruz-Guilloty, Ali M. Saeed, Jose J. Echegaray, Stephanie Duffort, Asha Ballmick, Yaohong Tan, Michel Betancourt, Eduardo Viteri, Ghansham C. Ramkhellawan, Eric Ewald, William Feuer, DeQiang Huang, Rong Wen, Li Hong, Hua Wang, James M. Laird, Abdoulaye Sene, Rajendra S. Apte, Robert G. Salomon, Joe G. Hollyfield, Victor L. Perez
Publikováno v:
International Journal of Inflammation, Vol 2013 (2013)
Age-related macular degeneration (AMD) is a major cause of blindness in the developed world. Oxidative stress and inflammation are implicated in AMD, but precise mechanisms remain poorly defined. Carboxyethylpyrrole (CEP) is an AMD-associated lipid p
Externí odkaz:
https://doaj.org/article/d8e9d3f8b21948ac95d0fd5ed4e8471a
Autor:
Abdoulaye Sene, Ramin Tadayoni, Thomas Pannicke, Antje Wurm, Brahim El Mathari, Romain Benard, Michel Joseph Roux, David Yaffe, Dominique Mornet, Andreas Reichenbach, Jose-Alain Sahel, Alvaro Rendon
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7329 (2009)
Functional alterations of Müller cells, the principal glia of the retina, are an early hallmark of most retina diseases and contribute to their further progression. The molecular mechanisms of these reactive Müller cell alterations, resulting in di
Externí odkaz:
https://doaj.org/article/a21adbcf2787426aa2e1fb3ad003df42
Publikováno v:
2022 IEEE International Conference on Electrical Sciences and Technologies in Maghreb (CISTEM).