2,3‐Epoxyamide‐alcohols in Domino Reactions: En Route to Molecular Diversity

Autor: Dr. Abderrahman El Bouakher, Dr. Jérôme Lhoste, Prof. Arnaud Martel, Dr. Sébastien Comesse

Publikováno v: ChemistryOpen, Vol 13, Iss 9, Pp n/a-n/a (2024)

Abstract The synthesis of polycyclic γ‐ and δ‐lactams bearing up to four contiguous fully controlled stereocenters is presented. For that purpose, we developed an original approach based on the use of 2,3‐epoxyamides in domino reactions by ta

Externí odkaz: https://doaj.org/article/b563ba62a8b94fa59b0da4c58364408c

α-Halogenoacetamides: versatile and efficient tools for the synthesis of complex aza-heterocycles

Autor: Abderrahman El Bouakher, Sébastien Comesse, Arnaud Martel

Publikováno v: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2019, 17 (37), pp.8467-8485. ⟨10.1039/C9OB01683J⟩

International audience; This review provides an overview of the applications of α-halogenoacetamides in domino and cycloaddition reactions. α-Halogenoacetamides are versatile building blocks that can lead to a wide variety of complex aza-heterocycl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a5551ca2f5f792060cfe95385f7eae
https://doi.org/10.1039/c9ob01683j

Pyrrolo-imidazo[1,2- a ]pyridine Scaffolds through a Sequential Coupling of N -Tosylhydrazones with Imidazopyridines and Reductive Cadogan Annulation, Synthetic Scope, and Application

Autor: Abderrahman El Bouakher, Mouad Alami, Pascal Retailleau, Jérôme Bignon, Kena Zhang, Abdallah Hamze, Hélène Levaique

Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2019, 84 (21), pp.13807-13823. ⟨10.1021/acs.joc.9b02018⟩

A new strategy for the construction of 3-phenyl-1H-pyrrolo-imidazo[1,2-a]pyridine backbone is described. The reaction starts from the coupling between N-tosylhydrazones and 2-chloro-3-nitroimidazo[1,2-a]pyridines leading to the formation of 3-nitro-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82387d752ca00702f54052a57f76b5f
https://hal.archives-ouvertes.fr/hal-02414103/document

Suzuki-Miyaura Reactions of Halospirooxindole Derivatives

Autor: Hassan Allouchi, Gérald Guillaumet, Isabelle Abrunhosa-Thomas, Abderrahman El Bouakher, Yves Troin

Publikováno v: European Journal of Organic Chemistry. 2015:3450-3461

Starting from 5,5′-dihalo-1′-pentyl-2H-spiro[furo[2,3-b]pyridine-3,3′-indolin]-2′-one, various 5,5′-di(het)aryl-1′-pentyl-2H-spiro[furo[2,3-b]pyridine-3,3′-indolin]-2′-ones were synthesized through palladium-catalysed cross-coupling r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c57c4c989a2a75cc8fa98d52bbf571e1
https://doi.org/10.1002/ejoc.201500268

Synthetic modification of 9 alpha- and 9 beta-hydroxyparthenolide by Heck or acylation reactions and evaluation of cytotoxic activities

Autor: Hassan Allouchi, Latifa Barkaoui, Eric Duverger, Gerald Guillaumet, Richard Daniellou, Mohamed Akssira, Abderrahman El Bouakher, Ahmed El Hakmaoui, Badr Jismy

Publikováno v: Planta Medica
Planta Medica, Georg Thieme Verlag, 2017, 83 (7), pp.661-671. ⟨10.1055/s-0042-119864⟩
Planta Medica, 2017, 83 (7), pp.661-671. ⟨10.1055/s-0042-119864⟩

International audience; Motivated by the widely reported anticancer activity of parthenolides and their derivatives, a series of new substituted parthenolides was efficiently synthesized. Structural modifications were performed at the C-9 and C-13 po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::338b21596eef4bbfb2269e57221f7f41
https://hal.archives-ouvertes.fr/hal-01604788