Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Abdelsattar M Omar"'
Publikováno v:
PLoS ONE, Vol 19, Iss 11, p e0312009 (2024)
Nematode infections impose a significant health and economic burden, particularly as parasites develop resistance to existing treatments and evade host defenses. This study explores the efficacy of 48 paraherquamide analogs, a class of polycyclic spi
Externí odkaz:
https://doaj.org/article/c5993bc950b649f6a0b39ae448c004e9
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0168938 (2017)
P-glycoprotein (Pgp) is a membrane bound efflux pump spread in a variety of tumor cells and considered as a main component of multidrug resistance (MDR) to chemotherapies. In this work, three groups of compounds (imidazolone, oxazolone and vinyl dipe
Externí odkaz:
https://doaj.org/article/c8ddc7c7bcc24c9b8794beea285517d7
Autor:
Tarek S. Ibrahim, Mohamed M. Hawwas, Azizah M. Malebari, Ehab S. Taher, Abdelsattar M. Omar, Thikryat Neamatallah, Zakaria K. Abdel-Samii, Martin K. Safo, Yaseen A. M. M. Elshaier
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 802-818 (2021)
A new series of quinoline derivatives of combretastatin A-4 have been designed, synthesised and demonstrated as tubulin polymerisation inhibitors. These novel compounds showed significant antiproliferative activities, among them, 12c exhibited the mo
Externí odkaz:
https://doaj.org/article/124b6c8bfcd643ab88f3712393e06660
Autor:
Abdelsattar M. Omar, Maan T. Khayat, Farid Ahmed, Yosra A. Muhammad, Azizah M. Malebari, Sara M. Ibrahim, Mohammad I. Khan, Dhaval K. Shah, Wayne E. Childers, Moustafa E. El-Araby
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Tirbanibulin (KX2-391, KX-01), a dual non-ATP (substrate site) Src kinase and tubulin-polymerization inhibitor, demonstrated a universal anti-cancer activity for variety of cancer types. The notion that KX2-391 is a highly selective Src kinase inhibi
Externí odkaz:
https://doaj.org/article/74f0539c28fe4afaab248255f807b3c2
Autor:
Maan T. Khayat, Abdelsattar M. Omar, Farid Ahmed, Mohammad I. Khan, Sara M. Ibrahim, Yosra A. Muhammad, Azizah M. Malebari, Thikryat Neamatallah, Moustafa E. El-Araby
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Structural changes of small-molecule drugs may bring interesting biological properties, especially in the field of kinase inhibitors. We sought to study tirbanibulin, a first-in-class dual Src kinase (non-ATP competitive)/tubulin inhibitor because th
Externí odkaz:
https://doaj.org/article/539bc391ade147b39a5632057cf3fa93
Autor:
Maan T. Khayat, Abdelsattar M. Omar, Mahmoud A. Elfaky, Yosra A. Muhammad, Elaf A. Felemban, Khalid M. El-Say, Moustafa E. El-Araby
Publikováno v:
Heteroatom Chemistry, Vol 2022 (2022)
Chronic Hepatitis C is a global health threat and a silent killer. Regardless of the profound progress in preventing and treating this disease, research continues to discover new direct antiviral agents (DAAs), especially against novel targets. Our r
Externí odkaz:
https://doaj.org/article/320200ef08d44feba563a7dac4ce48f5
Autor:
Sabrin R. M. Ibrahim, Abdelsattar M. Omar, Yosra A. Muhammad, Ali A. Alqarni, Abdullah M. Alshehri, Shaimaa G. A. Mohamed, Hossam M. Abdallah, Mahmoud A. Elfaky, Gamal A. Mohamed, Jianbo Xiao
Publikováno v:
Molecules, Vol 27, Iss 20, p 6797 (2022)
Phenaloenones are structurally unique aromatic polyketides that have been reported in both microbial and plant sources. They possess a hydroxy perinaphthenone three-fused-ring system and exhibit diverse bioactivities, such as cytotoxic, antimicrobial
Externí odkaz:
https://doaj.org/article/0b4184afcfc04934b929f6d57d484d76
Autor:
Boshi Huang, Mohini S. Ghatge, Akua K. Donkor, Faik N. Musayev, Tanvi M. Deshpande, Mohammed Al-Awadh, Rana T. Alhashimi, Hongmei Zhu, Abdelsattar M. Omar, Marilyn J. Telen, Yan Zhang, Tim J. McMahon, Osheiza Abdulmalik, Martin K. Safo
Publikováno v:
Molecules, Vol 27, Iss 20, p 6835 (2022)
Sickle cell disease (SCD) is caused by a single-point mutation, and the ensuing deoxygenation-induced polymerization of sickle hemoglobin (HbS), and reduction in bioavailability of vascular nitric oxide (NO), contribute to the pathogenesis of the dis
Externí odkaz:
https://doaj.org/article/065bb1f3e66e489a8d47e684c10f8021
Autor:
Maan T. Khayat, Hany E. A. Ahmed, Abdelsattar M. Omar, Yosra A. Muhammad, Khadijah A. Mohammad, Azizah M. Malebari, Ahdab N. Khayyat, Ahmed H. Halawa, Hamada S. Abulkhair, Ahmed A. Al-Karmalawy, Mohammed Almaghrabi, Majed Alharbi, Anfal S. Aljahdali, Ahmed M. El-Agrody
Publikováno v:
Journal of Biomolecular Structure and Dynamics. :1-19
All the previously reported phenylpyrazoles as carbonic anhydrase inhibitors (CAIs) were found to have small sizes and high levels of flexibility, and hence showed low selectivity profiles toward a particular isoform of CA. Herein, we report the deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7d76b8f65077cdfe75d2d84f242b04
https://doi.org/10.1080/07391102.2023.2188957
https://doi.org/10.1080/07391102.2023.2188957
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Phytochemical investigation of Buddleja indica Lam. leaves methanol extract (BIT) resulted in the isolation of six known compounds for the first time from the plant, namely, p-hydroxybenzoic acid 1), caffeic acid 2), quercetin 3-O-β-D glucoside-7-O-
Externí odkaz:
https://doaj.org/article/93a86d80d33c43bd803bffd962449ada