Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Abdelouahid Samadi"'
Autor:
Amneh Shtaiwi, Shafi Ullah Khan, Meriem Khedraoui, Mohd Alaraj, Abdelouahid Samadi, Samir Chtita
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Peptidoglycan is a carbohydrate with a cross-linked structure that protects the cytoplasmic membrane of bacterial cells from damage. The mechanism of peptidoglycan biosynthesis involves the main synthesizing enzyme glycosyltransferase MurG,
Externí odkaz:
https://doaj.org/article/aba60eb070e14f04b507a4c453790b25
Autor:
Nedjla Khelfa, Salah Belaidi, Oussama Abchir, Imane Yamari, Samir Chtita, Abdelouahid Samadi, Muneerah Mogren Al-Mogren, Majdi Hochlaf
Publikováno v:
Scientific African, Vol 24, Iss , Pp e02202- (2024)
Plasmodium falciparum dihydrofolate reductase (PfDHFR) is a promising therapeutic target for antimalarial interventions. Diaminodihydrotriazine derivatives have demonstrated their efficacy as antimalarial agents by targeting PfDHFR inhibition. In thi
Externí odkaz:
https://doaj.org/article/ab45d1614d5e4ab2a876b2e531f99ecc
Autor:
Marwa Manachou, Ossama Daoui, Oussama Abchir, Rahma Dahmani, Souad Elkhattabi, Abdelouahid Samadi, Salah Belaidi, Samir Chtita
Publikováno v:
Scientific African, Vol 23, Iss , Pp e02078- (2024)
Merging Density Functional Theory (DFT) with the Quantitative Structure-Activity Relationship (2D/3D-QSAR) modeling represents a promising avenue for exploring antibacterial activity and discovering potential drugs effective against both gram-positiv
Externí odkaz:
https://doaj.org/article/b6557d26bc8f4ab880b72795395ae46f
Autor:
Imane Yamari, Oussama Abchir, Hassan Nour, Meriem Khedraoui, Bouchra Rossafi, Abdelkbir Errougui, Mohammed Talbi, Abdelouahid Samadi, MHammed El Kouali, Samir Chtita
Publikováno v:
Pharmaceuticals, Vol 17, Iss 7, p 886 (2024)
Candida albicans and Aspergillus fumigatus are recognized as significant fungal pathogens, responsible for various human infections. The rapid emergence of drug-resistant strains among these fungi requires the identification and development of innova
Externí odkaz:
https://doaj.org/article/a2a8b695a815431981f09946be22d73a
Autor:
Meriem Khedraoui, Oussama Abchir, Hassan Nour, Imane Yamari, Abdelkbir Errougui, Abdelouahid Samadi, Samir Chtita
Publikováno v:
Pharmaceuticals, Vol 17, Iss 7, p 830 (2024)
Acetylcholinesterase (AChE) is one of the main drug targets for treating Alzheimer’s disease. This current study relies on multiple molecular modeling approaches to develop new potent inhibitors of AChE. We explored a 2D QSAR study using the statis
Externí odkaz:
https://doaj.org/article/c00fe19394ff443cb34ebc70bf5b8b8d
Autor:
Oussama Abchir, Meriem Khedraoui, Imane Yamari, Hassan Nour, Abdelkbir Errougui, Abdelouahid Samadi, Samir Chtita
Publikováno v:
PLoS ONE, Vol 19, Iss 9, p e0308308 (2024)
BackgroundThe increasing prevalence of diabetes and the side effects associated with current medications necessitate the development of novel candidate drugs targeting alpha-glucosidase as a potential treatment option.MethodsThis study employed compu
Externí odkaz:
https://doaj.org/article/e66078124efb4f0697ea528c611cb402
Autor:
Hind Yassmine Chennai, Salah Belaidi, Lotfi Bourougaa, Mebarka Ouassaf, Leena Sinha, Abdelouahid Samadi, Samir Chtita
Publikováno v:
Molecules, Vol 29, Iss 6, p 1232 (2024)
Huperzine A (HUP) plays a crucial role in Alzheimer’s therapy by enhancing cognitive function through increased cholinergic activity as a reversible acetylcholinesterase (AChE) inhibitor. Despite some limitations being seen in AChE inhibitors, ongo
Externí odkaz:
https://doaj.org/article/0367f0f051cf43f0b894f0ecc1c299e9
Autor:
Nour-El Houda Derki, Aicha Kerassa, Salah Belaidi, Maroua Derki, Imane Yamari, Abdelouahid Samadi, Samir Chtita
Publikováno v:
Molecules, Vol 29, Iss 4, p 822 (2024)
A set of 5-(substituted benzylidene) thiazolidine-2,4-dione derivatives was explored to study the main structural requirement for the design of protein tyrosine phosphatase 1B (PTP1B) inhibitors. Utilizing multiple linear regression (MLR) analysis, w
Externí odkaz:
https://doaj.org/article/0aad1191374b41e7b341b706e4f5d307
Autor:
Oussama Abchir, Meriem Khedraoui, Hassan Nour, Imane Yamari, Abdelkbir Errougui, Abdelouahid Samadi, Samir Chtita
Publikováno v:
Pharmaceuticals, Vol 17, Iss 2, p 261 (2024)
In response to the increasing prevalence of diabetes mellitus and the limitations associated with the current treatments, there is a growing need to develop novel medications for this disease. This study is focused on creating new compounds that exhi
Externí odkaz:
https://doaj.org/article/da8e5f1f5a764cbf960b7eb26891b1c3
Autor:
Khaoula Mkhayar, Ossama Daoui, Rachid Haloui, Kaouakeb Elkhattabi, Abdelmoula Elabbouchi, Samir Chtita, Abdelouahid Samadi, Souad Elkhattabi
Publikováno v:
Molecules, Vol 29, Iss 2, p 426 (2024)
In this study, using the Comparative Molecular Field Analysis (CoMFA) approach, the structure-activity relationship of 33 small quinoline-based compounds with biological anti-gastric cancer activity in vitro was analyzed in 3D space. Once the 3D geom
Externí odkaz:
https://doaj.org/article/fbaec9c3b7d44b16ae46aa631082407a