Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Abdelouahid Maghnouj"'
Autor:
Timm M. Reissig, Swetlana Ladigan‐Badura, Anja Steinberg, Abdelouahid Maghnouj, Ting Li, Berlinda Verdoodt, Sven T. Liffers, Michael Pohl, Heiner Wolters, Christian Teschendorf, Richard Viebahn, Jakob Admard, Nicolas Casadei, Andrea Tannapfel, Wolff Schmiegel, Stephan A. Hahn, Deepak B. Vangala
Publikováno v:
Molecular Oncology, Vol 17, Iss 11, Pp 2396-2414 (2023)
Although approximately half of all metastatic colorectal cancers (mCRCs) harbour mutations in KRAS or NRAS, hardly any progress has been made regarding targeted treatment for this group over the last few years. Here, we investigated the efficacy of v
Externí odkaz:
https://doaj.org/article/43b89c56d838488bb188749e4ab6758c
Autor:
Deepak Vangala, Swetlana Ladigan, Sven T. Liffers, Soha Noseir, Abdelouahid Maghnouj, Tina-Maria Götze, Berlinda Verdoodt, Susanne Klein-Scory, Laura Godfrey, Martina K. Zowada, Mario Huerta, Daniel L. Edelstein, Jaime Martinez de Villarreal, Miriam Marqués, Jörg Kumbrink, Andreas Jung, Tobias Schiergens, Jens Werner, Volker Heinemann, Sebastian Stintzing, Doris Lindoerfer, Ulrich Mansmann, Michael Pohl, Christian Teschendorf, Christiane Bernhardt, Heiner Wolters, Josef Stern, Selami Usta, Richard Viebahn, Jacob Admard, Nicolas Casadei, Stefan Fröhling, Claudia R. Ball, Jens T. Siveke, Hanno Glimm, Andrea Tannapfel, Wolff Schmiegel, Stephan A. Hahn
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-25 (2021)
Abstract Background The development of secondary resistance (SR) in metastatic colorectal cancer (mCRC) treated with anti-epidermal growth factor receptor (anti-EGFR) antibodies is not fully understood at the molecular level. Here we tested in vivo s
Externí odkaz:
https://doaj.org/article/cfb1d471a175414a977bd791dd7bb74a
Autor:
Thomas Mika, Swetlana Ladigan-Badura, Abdelouahid Maghnouj, Bakr Mustafa, Susanne Klein-Scory, Alexander Baraniskin, Sascha Döhring, Ilka Fuchs, Stephan Ehl, Stephan A. Hahn, Roland Schroers
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
In relapsed and refractory multiple myeloma (MM), adoptive cell therapies (ACT) including CAR-T-cells are under clinical investigation. However, relapse due to T-cell exhaustion or limited persistence is an obstacle. Before ACT are considered in MM,
Externí odkaz:
https://doaj.org/article/d94bd402625c41a988eef188e6eb6f34
Autor:
Thomas Mika, Abdelouahid Maghnouj, Susanne Klein-Scory, Swetlana Ladigan-Badura, Alexander Baraniskin, Julia Thomson, Justin Hasenkamp, Stephan A. Hahn, Gerald Wulf, Roland Schroers
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
CD19-directed CAR-T-cells (CD19-CAR) have demonstrated remarkable clinical results in patients suffering from refractory or relapsed lymphoma and acute lymphoblastic leukemia. In order to further optimize follow-up, to explain treatment failure, and
Externí odkaz:
https://doaj.org/article/3a9764fb36b54d578ed96f5ac443b16a
Autor:
Kaibo Xie, Marharyta Varatnitskaya, Abdelouahid Maghnouj, Verian Bader, Konstanze F. Winklhofer, Stephan Hahn, Lars I. Leichert
Publikováno v:
Redox Biology, Vol 28, Iss , Pp - (2020)
Neutrophils produce a cocktail of oxidative species during the so-called oxidative burst to attack phagocytized bacteria. However, little is known about the neutrophils' redox homeostasis during the oxidative burst and there is currently no consensus
Externí odkaz:
https://doaj.org/article/9f4c46784d9348f28c75f90f9d8ce9d6
Autor:
Julian Gehmeyr, Abdelouahid Maghnouj, Jonas Tjaden, Matthias Vorgerd, Stephan Hahn, Veronika Matschke, Verena Theis, Carsten Theiss
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 2173 (2021)
The vascular endothelial growth factor (VEGF) is well known for its wide-ranging functions, not only in the vascular system, but also in the central (CNS) and peripheral nervous system (PNS). To study the role of VEGF in neuronal protection, growth a
Externí odkaz:
https://doaj.org/article/bbe3990824804cd49ce644b234ef2955
Autor:
Karin Birkenkamp-Demtröder, Stephan A Hahn, Francisco Mansilla, Kasper Thorsen, Abdelouahid Maghnouj, Rikke Christensen, Bodil Øster, Torben Falck Ørntoft
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73593 (2013)
Keratin 23 (KRT23) is strongly expressed in colon adenocarcinomas but absent in normal colon mucosa. Array based methylation profiling of 40 colon samples showed that the promoter of KRT23 was methylated in normal colon mucosa, while hypomethylated i
Externí odkaz:
https://doaj.org/article/0d933cb775604d5aa5d1b7c8dc98ad98
Autor:
Jonas Althaus, Verena Nilius-Eliliwi, Abdelouahid Maghnouj, Sascha Döring, Roland Schroers, Michael Hudecek, Stephan A. Hahn, Thomas Mika
Publikováno v:
Cancer Immunology, Immunotherapy.
Chimeric antigen receptors (CARs) have improved cancer immunotherapy in recent years. Immune cells, such as Natural killer cells (NK-cells) or T cells, are used as effector cells in CAR-therapy. NK92-cells, a cell line with known cytotoxic activity,
Autor:
Stephan A. Hahn, Abdelouahid Maghnouj, Thilo Bracht, Michael Turewicz, Martin Eisenacher, Karin Schork, Barbara Sitek, Birgit Zülch, Markus Stepath
Publikováno v:
Journal of proteome research. 19(2)
We evaluated the quantification strategies label-free (LF), stable isotope labeling by amino acids in cell culture (SILAC), and tandem mass tags (TMT) and their performance in quantification of proteins and phosphosites (p-sites) to identify the most
Autor:
Stephan A. Hahn, Konstanze F. Winklhofer, Marharyta Varatnitskaya, Kaibo Xie, Abdelouahid Maghnouj, Lars I. Leichert, Verian Bader
Publikováno v:
Redox Biology
Redox Biology, Vol 28, Iss, Pp-(2020)
Redox Biology, Vol 28, Iss, Pp-(2020)
Neutrophils produce a cocktail of oxidative species during the so-called oxidative burst to attack phagocytized bacteria. However, little is known about the neutrophils' redox homeostasis during the oxidative burst and there is currently no consensus