Machine learning applied to enzyme turnover numbers reveals protein structural correlates and improves metabolic models

Autor: David Heckmann, Colton J. Lloyd, Nathan Mih, Yuanchi Ha, Daniel C. Zielinski, Zachary B. Haiman, Abdelmoneim Amer Desouki, Martin J. Lercher, Bernhard O. Palsson

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)

Experimental data on enzyme turnover numbers is sparse and noisy. Here, the authors use machine learning to successfully predict enzyme turnover numbers for E. coli, and show that using these to parameterize mechanistic genome-scale models enhances t

Externí odkaz: https://doaj.org/article/4253a943492247b28ad5cd46f32d93b3

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Pirfenidone targeted mechanisms for alleviating methotrexate-induced testiculopathy in Wistar rats.

Autor: Mersal EA; Vision Colleges, Riyadh, Saudi Arabia. mersalezzat@gmail.com., Morsi AA; Vision Colleges, Riyadh, Saudi Arabia., Alkahtani J; Vision Colleges, Riyadh, Saudi Arabia., Alhalal R; Vision Colleges, Riyadh, Saudi Arabia., Alessa S; Vision Colleges, Riyadh, Saudi Arabia., Shehab A; Vision Colleges, Riyadh, Saudi Arabia., Sakr EM; Vision Colleges, Riyadh, Saudi Arabia., Sabir DK; Department of Medical Surgical Nursing, College of Nursing, Princess Nourah bint Abdulrahman University, P.O. Box 84428, 11671, Riyadh, Saudi Arabia., Dawood AF; Department of Basic Medical Sciences, College of Medicine, Princess Nourah bint Abdulrahman University, P.O. Box 84428, 11671, Riyadh, Saudi Arabia., Abdelmoneim AM; Department of Physiology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.

Publikováno v: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2024 Sep 02. Date of Electronic Publication: 2024 Sep 02.

ACE2/ACE imbalance mediates bisphenol A-induced lung injury in Wistar rats: Results from captopril versus losartan histo-biochemical study.

Autor: Morsi AA; Department of Histology and Cell Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Mersal EA; Biochemistry Department, Faculty of Science, Assiut University, Assiut, Egypt.; Department of Basic Medical Sciences, Vision Colleges, Riyadh, Saudi Arabia., Abdelmoneim AM; Physiology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Faruk EM; Anatomy Department, College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.; Department of Histology and Cytology, Faculty of Medicine, Benha University, Benha, Egypt., Sofii MM; Department of Anatomy and Embryology, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Sadek NA; Department of Histology and Cell Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Ibrahim KE; Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia., Aljanfawe HJ; Vision Colleges, Riyadh, Saudi Arabia., Elmadhoun I; Vision Colleges, Riyadh, Saudi Arabia., Mubarak W; Vision Colleges, Riyadh, Saudi Arabia., Mahmoud MM; Vision Colleges, Riyadh, Saudi Arabia., Salim MS; Medical Laboratory Technology Department, Higher Technological Institute of Applied Health Sciences, Beni-Suef, Egypt.

Publikováno v: Heliyon [Heliyon] 2023 Nov 04; Vol. 9 (11), pp. e22056. Date of Electronic Publication: 2023 Nov 04 (Print Publication: 2023).