Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Abdellatif Benraiss"'
Autor:
John N. Mariani, Benjamin Mansky, Pernille M. Madsen, Dennis Salinas, Deniz Kesmen, Nguyen P. T. Huynh, Nicholas J. Kuypers, Erin R. Kesel, Janna Bates, Casey Payne, Devin Chandler-Militello, Abdellatif Benraiss, Steven A. Goldman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Human glial progenitor cells (hGPCs) exhibit diminished expansion competence with age, as well as after recurrent demyelination. Using RNA-sequencing to compare the gene expression of fetal and adult hGPCs, we identify age-related changes in
Externí odkaz:
https://doaj.org/article/5d6bbb20559247ef91df3bdc2e5860bf
Autor:
Zhengshan Liu, Mikhail Osipovitch, Abdellatif Benraiss, Nguyen P.T. Huynh, Rossana Foti, Janna Bates, Devin Chandler-Militello, Robert L. Findling, Paul J. Tesar, Maiken Nedergaard, Martha S. Windrem, Steven A. Goldman
Publikováno v:
Cell Reports, Vol 27, Iss 13, Pp 3832-3843.e6 (2019)
Summary: Astrocytic differentiation is developmentally impaired in patients with childhood-onset schizophrenia (SCZ). To determine why, we used genetic gain- and loss-of-function studies to establish the contributions of differentially expressed tran
Externí odkaz:
https://doaj.org/article/16ab12112b63407da85af17b18749977
Autor:
Anne Sofie Munk, Wei Wang, Nicholas Burdon Bèchet, Ahmed M. Eltanahy, Anne Xiaoan Cheng, Björn Sigurdsson, Abdellatif Benraiss, Maarja A. Mäe, Benjamin Travis Kress, Douglas H. Kelley, Christer Betsholtz, Kjeld Møllgård, Anja Meissner, Maiken Nedergaard, Iben Lundgaard
Publikováno v:
Cell Reports, Vol 26, Iss 11, Pp 2955-2969.e3 (2019)
Summary: The glymphatic system is a highly polarized cerebrospinal fluid (CSF) transport system that facilitates the clearance of neurotoxic molecules through a brain-wide network of perivascular pathways. Herein we have mapped the development of the
Externí odkaz:
https://doaj.org/article/5b77896f85a4421cba8e2c229b4cb483
Autor:
Abdellatif Benraiss, Su Wang, Stephanie Herrlinger, Xiaojie Li, Devin Chandler-Militello, Joseph Mauceri, Hayley B. Burm, Michael Toner, Mikhail Osipovitch, Qiwu Jim Xu, Fengfei Ding, Fushun Wang, Ning Kang, Jian Kang, Paul C. Curtin, Daniela Brunner, Martha S. Windrem, Ignacio Munoz-Sanjuan, Maiken Nedergaard, Steven A. Goldman
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The contribution of glia to Huntington's disease is unclear. The authors show that human glial progenitor cells (GPCs) expressing mutant huntingtin impair motor performance when engrafted into wild type mice, and wild type human GPCs ameliorate disea
Externí odkaz:
https://doaj.org/article/1efcf5bbea644ef3ac2340ad9aa2efda
Autor:
Romane M. Auvergne, Fraser J. Sim, Su Wang, Devin Chandler-Militello, Jaclyn Burch, Yazan Al Fanek, Danielle Davis, Abdellatif Benraiss, Kevin Walter, Pragathi Achanta, Mahlon Johnson, Alfredo Quinones-Hinojosa, Sridaran Natesan, Heide L. Ford, Steven A. Goldman
Publikováno v:
Cell Reports, Vol 3, Iss 6, Pp 2127-2141 (2013)
Glial progenitor cells (GPCs) are a potential source of malignant gliomas. We used A2B5-based sorting to extract tumorigenic GPCs from human gliomas spanning World Health Organization grades II–IV. Messenger RNA profiling identified a cohort of gen
Externí odkaz:
https://doaj.org/article/c913227625b54a87a8743ed21b7119cc
Autor:
Carlos Benitez Villanueva, Hans J. T. Stephensen, Rajmund Mokso, Abdellatif Benraiss, Jon Sporring, Steven A. Goldman
Publikováno v:
Villanueva, C B, Stephensen, H J T, Mokso, R, Benraiss, A, Sporring, J & Goldman, S A 2023, ' Astrocytic engagement of the corticostriatal synaptic cleft is disrupted in a mouse model of Huntington’s disease ', Proceedings of the National Academy of Sciences USA (PNAS), vol. 120, no. 24, e2210719120 . https://doi.org/10.1073/pnas.2210719120
Astroglial dysfunction contributes to the pathogenesis of Huntington’s disease (HD), and glial replacement can ameliorate disease course. To establish the topographic relationship of diseased astrocytes to medium spiny neuron (MSN) synapses in HD,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd616a883c549e8b4594cb1ff119fc6e
https://curis.ku.dk/portal/da/publications/astrocytic-engagement-of-the-corticostriatal-synaptic-cleft-is-disrupted-in-a-mouse-model-of-huntingtons-disease(731f8b69-986d-4f26-92fe-c0b62f9ce5a0).html
https://curis.ku.dk/portal/da/publications/astrocytic-engagement-of-the-corticostriatal-synaptic-cleft-is-disrupted-in-a-mouse-model-of-huntingtons-disease(731f8b69-986d-4f26-92fe-c0b62f9ce5a0).html
Autor:
Abdellatif Benraiss, John N. Mariani, Ashley Tate, Pernille M. Madsen, Kathleen M. Clark, Kevin A. Welle, Renee Solly, Laetitia Capellano, Karen Bentley, Devin Chandler-Militello, Steven A. Goldman
Publikováno v:
Benraiss, A, Mariani, J N, Tate, A, Madsen, P M, Clark, K M, Welle, K A, Solly, R, Capellano, L, Bentley, K, Chandler-Militello, D & Goldman, S A 2022, ' A TCF7L2-responsive suppression of both homeostatic and compensatory remyelination in Huntington disease mice ', Cell Reports, vol. 40, no. 9, 111291 . https://doi.org/10.1016/j.celrep.2022.111291
Huntington’s disease (HD) is characterized by defective oligodendroglial differentiation and white matter disease. Here, we investigate the role of oligodendrocyte progenitor cell (OPC) dysfunction in adult myelin maintenance in HD. We first note a
Autor:
Martha S. Windrem, Mikhail Osipovitch, Devin Chandler-Militello, Abdellatif Benraiss, Steven A. Goldman, Carlos Benitez Villanueva, John N. Mariani, Adam Cornwell
Publikováno v:
Benraiss, A, Mariani, J N, Osipovitch, M, Cornwell, A, Windrem, M S, Villanueva, C B, Chandler-Militello, D & Goldman, S A 2021, ' Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease ', Cell Reports, vol. 36, no. 1, 109308 . https://doi.org/10.1016/j.celrep.2021.109308
Glial pathology is a causal contributor to the striatal neuronal dysfunction of Huntington's disease (HD). We investigate mutant HTT-associated changes in gene expression by mouse and human striatal astrocytes, as well as in mouse microglia, to ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b206d15dbfad3f84e0ea8f4d27df81c8
https://curis.ku.dk/portal/da/publications/cellintrinsic-glial-pathology-is-conserved-across-human-and-murine-models-of-huntingtons-disease(c3ca9d6a-32a3-4218-8682-ce9366a925d3).html
https://curis.ku.dk/portal/da/publications/cellintrinsic-glial-pathology-is-conserved-across-human-and-murine-models-of-huntingtons-disease(c3ca9d6a-32a3-4218-8682-ce9366a925d3).html
Autor:
Erin R. Kesel, Nicholas J. Kuypers, Benjamin Mansky, Steven A. Goldman, Pernille M. Madsen, Nguyen P.T. Huynh, John N. Mariani, Devin Chandler-Militello, Abdellatif Benraiss
Publikováno v:
SSRN Electronic Journal.
Autor:
Devin Chandler-Militello, Steven A. Goldman, Abdellatif Benraiss, John N. Mariani, Laetitia Capellano, Renee Solly, Karen L. de Mesy Bentley, Ashley Tate
Publikováno v:
SSRN Electronic Journal.
Huntington’s disease (HD) is characterized by defective oligodendroglial differentiation and white matter disease. Here, we investigated the role of glial progenitor cell (GPC) dysfunction in adult myelin maintenance in HD. We first noted a progres