Výsledky vyhledávání - "Abdelkrim OUAMMOU"

Akademický článek

Thermoactinomyces sacchari competent strain: Isolation from compost, selection and characterization for biotechnological use

Autor: Beroigui Oumaima, Chadli Nour-Eddine, Raoui S. Mohammed, Abdelkrim Ouammou, Chedadi Oussama, Errachidi Faouzi

Publikováno v: Scientific African, Vol 23, Iss , Pp e02121- (2024)

Composting is an uncontrolled process of converting organic waste into a beneficial soil conditioner for agriculture. During this process, a diverse community of micro-organisms, including thermophilic bacteria and actinomycetes, plays an essential r

Externí odkaz: https://doaj.org/article/e575db26a1ea40afa78d7617f1985b1d

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Akademický článek

Molecular Docking, Drug likeness Studies and ADMET prediction of Flavonoids as Platelet-Activating Factor (PAF) Receptor Binding

Autor: Mohammed BOUACHRINE, Larbi Elmchichi, Abdellah El Aissouq, Assia BELHASSAN, Hanane Zaki, Abdelkrim Ouammou, Tahar Lakhlifi

Publikováno v: Chemical Review and Letters, Vol 4, Iss 3, Pp 145-152 (2021)

Studies and scientific research indicate that the platelet-activating factor (PAF) is a major pro-inflammatory mediator in the initiation and development of cancer. There is also evidence confirming that PAF is an integral part of suppressing the imm

Externí odkaz: https://doaj.org/article/5a91c7b43321492694839ff91fb1d1f4

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Akademický článek

Identification of Novel SARS-CoV-2 Inhibitors: A Structure-Based Virtual Screening Approach

Autor: Abdellah El Aissouq, Oussama Chedadi, Mohammed Bouachrine, Abdelkrim Ouammou

Publikováno v: Journal of Chemistry, Vol 2021 (2021)

The recent outbreak of the coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) in the last few months raised global health concern. Previous research described that remdesivir and ritonavir can b

Externí odkaz: https://doaj.org/article/f9180643ef6f419db81cf9cd0fb287ab

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Akademický článek

2D-QSAR and docking study of a series of coumarin derivatives as inhibitors of CDK (anticancer activity) with an application of the molecular docking method

Autor: Rania Kasmi, Elghalia Hadaji, Oussama Chedadi, Abdellah El Aissouq, Mohammed Bouachrine, Abdelkrim Ouammou

Publikováno v: Heliyon, Vol 6, Iss 8, Pp e04514- (2020)

Quantitative Structure Activity Relationship (QSAR) analysis techniques are tools largely utilized in many research fields, including drug discovery processes.In this work electronic descriptors are calculated with the Gaussian 03W software using the

Externí odkaz: https://doaj.org/article/5c7c03c83ec5476f9d72602c876fe818

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Akademický článek

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In silico studies of N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl) piperazine-1-carboxamide derivatives as potent TRPV1 antagonists using 3D QSAR, ADMET and Molecular Docking

Autor: Abdelilah TOUGHZAOUI, oussama CHEDADI, Abdellah EL AISSOUQ, youssef El Ouardi, Mohammed BOUACHRINE, Abdelkrim OUAMMOU, kamal MORADI

TRPV1 is a promising therapeutic target given its involvement in pain management and inflammation. TRPV1 antagonists are increasingly sought after for their analgesic, anti-inflammatory and antitumor properties with fewer side effects. This study foc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72ed6bcb120006884919c6e1aaf2cd08
https://doi.org/10.21203/rs.3.rs-2962717/v1

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Development of novel monoamine oxidase B (MAO-B) inhibitors by combined application of docking-based alignment, 3D-QSAR, ADMET prediction, molecular dynamics simulation, and MM_GBSA binding free energy

Autor: Abdellah El Aissouq, Oussama Chedadi, Mohammed Bouachrine, Abdelkrim Ouammou, Fouad Khalil

Publikováno v: Journal of Biomolecular Structure and Dynamics. :1-14

Unsaturated ketone derivatives are known as inhibitors of monoamine oxidase B (MAO-B), a potential drug target of Parkinson’s disease. Here, docking-based alignment, 3 D-QSAR (three-dimensional quantitative structure-activity relationship) studies,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::144e5e4491df3f1f583df22e3741328c
https://doi.org/10.1080/07391102.2022.2071341

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3D-QSAR modeling and molecular docking studies on a series of 2, 4, 5-trisubstituted imidazole derivatives as CK2 inhibitors

Autor: Amina Goudzal, Abdellah El Aissouq, Hicham El Hamdani, El Ghalia Hadaji, Abdelkrim Ouammou, Mohammed Bouachrine

Publikováno v: Journal of Biomolecular Structure and Dynamics. 41:234-248

Protein case in kinase II alpha subunit (CK2) plays an imperative function in treating cancer disease. Herein, we have performed a three-dimensional quantitative structure activity relationship (3D-QSAR), and molecular docking analysis on a novel ser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e622d1947fb929946959b512246a605
https://doi.org/10.1080/07391102.2021.2014360

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QSAR and molecular docking study of quinolin derivatives with topoisomerase I inhibitory properties as potential anticancer agents using statistical methods

Autor: Mohammed Bouachrine, Abdelkrim Ouammou, El Ghalia Hadaji, H. El Hamdani

Publikováno v: Materials Today: Proceedings. 51:1838-1850

The work presented in this article aims to develop reliable and predictive QSAR models to identify key molecular factors explaining the interaction effect (electronic / penetration), and establish reliable explanatory QSAR (quantitative relationship

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a269d9241c0736e5664f32dbe1ff3d66
https://doi.org/10.1016/j.matpr.2020.08.032

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