Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Abdelkader, Essafi"'
Autor:
Silvia Peluso, Adam Douglas, Alison Hill, Carlo De Angelis, Benjamin L Moore, Graeme Grimes, Giulia Petrovich, Abdelkader Essafi, Robert E Hill
Publikováno v:
eLife, Vol 6 (2017)
Sonic hedgehog (Shh) expression in the limb bud organizing centre called the zone of polarizing activity is regulated by the ZRS enhancer. Here, we examine in mouse and in a mouse limb-derived cell line the dynamic events that activate and restrict t
Externí odkaz:
https://doaj.org/article/57a9b1e518c742868362ba4b6c256a7b
Autor:
Gordan Lauc, Abdelkader Essafi, Jennifer E Huffman, Caroline Hayward, Ana Knežević, Jayesh J Kattla, Ozren Polašek, Olga Gornik, Veronique Vitart, Jodie L Abrahams, Maja Pučić, Mislav Novokmet, Irma Redžić, Susan Campbell, Sarah H Wild, Fran Borovečki, Wei Wang, Ivana Kolčić, Lina Zgaga, Ulf Gyllensten, James F Wilson, Alan F Wright, Nicholas D Hastie, Harry Campbell, Pauline M Rudd, Igor Rudan
Publikováno v:
PLoS Genetics, Vol 6, Iss 12, p e1001256 (2010)
Over half of all proteins are glycosylated, and alterations in glycosylation have been observed in numerous physiological and pathological processes. Attached glycans significantly affect protein function; but, contrary to polypeptides, they are not
Externí odkaz:
https://doaj.org/article/0bedf96abf874f8498dbe8e95fd5af17
Autor:
Stuart Aitken, Viktoriya Stancheva, Jocelyn Charlton, Nicholas D. Hastie, Ruthrothaselvi Bharathavikru, Joan Slight, Giulia Petrovich, Kathy Pritchard-Jones, Abdelkader Essafi
Wilms’ tumour 1 (WT1) is a transcription factor and a tumour suppressor, essential for the development and homeostasis of multiple tissues derived from the intermediate and lateral plate mesoderm. Germline WT1 mutations result in the eponymous paed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d4169bdec49dea9fc4c1b654be537c
Autor:
Ian M. Overton, Jeremy A. Owen, Bret S E Heale, Erola Pairo-Castineira, Abdelkader Essafi, Matthew J. Ford, Andrew H. Sims, Alexander L. R. Lubbock
Publikováno v:
Cancers, Vol 12, Iss 2823, p 2823 (2020)
overton, I, Sims, A, Owen, J, Heale, B, Ford, M, Lubbock, A, Pairo-Castineira, E & Essafi, A 2020, ' Functional Transcription Factor Target Networks Illuminate Control of Epithelial Remodelling ', Cancers, vol. 12, no. 10, 2823 . https://doi.org/10.3390/cancers12102823
Cancers
Volume 12
Issue 10
Overton, I M, Sims, A H, Owen, J A, Heale, B S E, Ford, M J, Lubbock, A L R, Pairo-Castineira, E & Essafi, A 2020, ' Functional Transcription Factor Target Networks Illuminate Control of Epithelial Remodelling ', Cancers, vol. 12, no. 10, 2823 . https://doi.org/10.3390/cancers12102823
Overton, I, Sims, A H, A. Owen, J, S. E Heale, B, Ford, M J, Lubbock, A, Pairo-Castineira, E & Essafi, A 2020, ' Functional Transcription Factor Target Networks Illuminate Control of Epithelial Remodelling ', Cancers . https://doi.org/10.3390/cancers12102823
overton, I, Sims, A, Owen, J, Heale, B, Ford, M, Lubbock, A, Pairo-Castineira, E & Essafi, A 2020, ' Functional Transcription Factor Target Networks Illuminate Control of Epithelial Remodelling ', Cancers, vol. 12, no. 10, 2823 . https://doi.org/10.3390/cancers12102823
Cancers
Volume 12
Issue 10
Overton, I M, Sims, A H, Owen, J A, Heale, B S E, Ford, M J, Lubbock, A L R, Pairo-Castineira, E & Essafi, A 2020, ' Functional Transcription Factor Target Networks Illuminate Control of Epithelial Remodelling ', Cancers, vol. 12, no. 10, 2823 . https://doi.org/10.3390/cancers12102823
Overton, I, Sims, A H, A. Owen, J, S. E Heale, B, Ford, M J, Lubbock, A, Pairo-Castineira, E & Essafi, A 2020, ' Functional Transcription Factor Target Networks Illuminate Control of Epithelial Remodelling ', Cancers . https://doi.org/10.3390/cancers12102823
Cell identity is governed by gene expression, regulated by transcription factor (TF) binding at cis-regulatory modules. Decoding the relationship between TF binding patterns and gene regulation is nontrivial, remaining a fundamental limitation in und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eccfd0e66fe9613a01944d2f44cdf4b
https://doi.org/10.3390/cancers12102823
https://doi.org/10.3390/cancers12102823
Autor:
Alexander L. R. Lubbock, Andrew H. Sims, Jeremy A. Owen, Matthew J. Ford, Ian M. Overton, Bret S E Heale, Erola Pairo-Castineira, Abdelkader Essafi
Cell identity is governed by gene expression, regulated by Transcription Factor (TF) binding at cis-regulatory modules. Decoding the relationship between patterns of TF binding and the regulation of cognate target genes is nontrivial, remaining a fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ac20842375289d4d33a4043467d6eeb
Autor:
Silvia Peluso, Adam Douglas, Alison Hill, Carlo De Angelis, Benjamin L Moore, Graeme Grimes, Giulia Petrovich, Abdelkader Essafi, Robert E Hill
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1e25caac7a3789a0c8afe96175605da
https://doi.org/10.7554/elife.28590.019
https://doi.org/10.7554/elife.28590.019
Autor:
Abdelkader Essafi, Alison E. Hill, Laura A. Lettice, Richard L. Mort, John H. Wiltshire, Paul S. Devenney, Robert E. Hill, James Hagman, Graeme R. Grimes, Carlo L. DeAngelis, Silvia Peluso, Iain Williamson
Publikováno v:
Lettice, L A, Williamson, I, Wiltshire, J H, Peluso, S, Devenney, P S, Hill, A E, Essafi, A, Hagman, J, Mort, R, Grimes, G, DeAngelis, C L & Hill, R E 2012, ' Opposing functions of the ETS factor family define Shh spatial expression in limb buds and underlie polydactyly ', Developmental Cell, vol. 22, no. 2, pp. 459-67 . https://doi.org/10.1016/j.devcel.2011.12.010
Developmental Cell
Developmental Cell
Summary Sonic hedgehog (Shh) expression during limb development is crucial for specifying the identity and number of digits. The spatial pattern of Shh expression is restricted to a region called the zone of polarizing activity (ZPA), and this expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4161f411777a872b6a78922530ac1964
Autor:
Angharad M. Shore, Rosaline C.-Y. Hui, Eric Lam, Paul Charles White, Martin Rowe, Paul Brennan, Abdelkader Essafi
Publikováno v:
Journal of Virology. 80:11191-11199
Epstein-Barr virus (EBV) infection is associated with the development of many B-cell lymphomas, including Burkitt's lymphoma, Hodgkin's lymphoma, and posttransplant lymphoproliferative disease. The virus alters a diverse range of cellular molecules,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b7be969824a1cd682870435c1b73599
https://doi.org/10.1128/jvi.00983-06
https://doi.org/10.1128/jvi.00983-06
Autor:
Eric Lam, Patricia A. Madureira, Rana Varshochi, Silvia Fernández de Mattos, Georgia Zoumpoulidou, Julia M. Francis, Luca Fusi, Abdelkader Essafi, Marius C. Jones, Takeshi Kajihara, Jan J. Brosens, Soraya Labied, Jenny M. Higham
Publikováno v:
Molecular Endocrinology. 20:35-44
Menstruation, or cyclic shedding of nonpregnant endometrial tissue with associated bleeding, occurs only in humans and a few other species. This breakdown of the endometrium in response to falling ovarian progesterone levels is a complex process, cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c86dceaec8661c17176e0a15cde083f
https://doi.org/10.1210/me.2005-0275
https://doi.org/10.1210/me.2005-0275
Autor:
Abdelkader Essafi, Nicholas D. Hastie
Publikováno v:
Molecular Cell. 37:153-155
Here, Hartkamp et al. (2010) identify WT1 as a novel bona fide substrate of the HtrA2/Omi mitochondrial protease and show that this reaction modulates WT1 antiapoptotic activity under cytotoxic stress. This supports an oncogenic function for WT1, wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b32801cdebcc1463da9371da4c9653b6
https://doi.org/10.1016/j.molcel.2010.01.010
https://doi.org/10.1016/j.molcel.2010.01.010