Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Abdelilah S Gounni"'
Autor:
Lianyu Shan, Mojdeh Matloubi, Ifeoma Okwor, Sam Kung, Mohamed Sadek Almiski, Sujata Basu, Andrew Halayko, Latifa Koussih, Abdelilah S Gounni
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0309868 (2024)
Dendritic cells (DCs) are pivotal in regulating allergic asthma. Our research has shown that the absence of Sema3E worsens asthma symptoms in acute and chronic asthma models. However, the specific role of PlexinD1 in these processes, particularly in
Externí odkaz:
https://doaj.org/article/2f0cab41bf624d9d9c70bd1042d48553
Publikováno v:
Advances in Biomedical and Health Sciences, Vol 1, Iss 4, Pp 189-195 (2022)
Semaphorins are cell-membrane bound or secretory proteins that regulate cell migration, differentiation, proliferation, and morphology. Semaphorins are guidance cues that have either repulsive or attractive effects on growth cones and thus determine
Externí odkaz:
https://doaj.org/article/3b6710ae54794371b2722977fb328743
Autor:
Hesam Movassagh, Lianyu Shan, Latifa Koussih, Abdulaziz Alamri, Nazila Ariaee, Sam K P Kung, Abdelilah S Gounni
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252868 (2021)
Regulation of dendritic cell functions is a complex process in which several mediators play diverse roles as a network in a context-dependent manner. The precise mechanisms underlying dendritic cell functions have remained to be addressed. Semaphorin
Externí odkaz:
https://doaj.org/article/3d4a970dab344957a40f014fb329ce8e
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0220772 (2019)
Pentraxin-3 (PTX3) is a multifunctional protein involved in both innate and adaptive immunity. Glucocorticoid (GC) is the first-line therapy to mitigate airway inflammation in asthma. Previous pieces of evidence showed that GC has divergent effects o
Externí odkaz:
https://doaj.org/article/a085ce45733645ce9d4877c1be11f5e4
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93946 (2014)
Previous studies have shown that enhanced accumulation of contractile proteins such as smooth muscle myosin light chain kinase (smMLCK) plays a major role in human airway smooth muscle cells (HASM) cell hypercontractility and hypertrophy. Furthermore
Externí odkaz:
https://doaj.org/article/e1c77ab51d19426388a3ed688468451c
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59631 (2013)
BALB/c mice are highly susceptible while C57BL/6 mice are relatively resistant to experimental Trypanosoma congolense infection. Several reports show that an early interferon-gamma (IFN-γ) response in infected mice is critically important for resist
Externí odkaz:
https://doaj.org/article/176d2e6d639846a393cd5ed491a2930d
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55249 (2013)
Previous studies have shown that delayed neutrophil apoptosis is associated with chronic airway diseases. Leptin is an adipocyte-derived hormone that acts as a regulator of energy homeostasis and food intake. Emerging evidence suggests that leptin ca
Externí odkaz:
https://doaj.org/article/fdb88ef6786f47b6a9160e1d6329f205
Autor:
Jingbo Zhang, Lianyu Shan, Latifa Koussih, Naresh Singh Redhu, Andrew J Halayko, Jamila Chakir, Abdelilah S Gounni
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34965 (2012)
Pentraxin 3 (PTX3) is a soluble pattern recognition receptor with non-redundant functions in inflammation and innate immunity. PTX3 is produced by immune and structural cells. However, very little is known about the expression of PTX3 and its role in
Externí odkaz:
https://doaj.org/article/0916f02e21264c5caa94638feece4675
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9178 (2010)
Previous findings support the concept that IL-9 may play a significant role in mediating both pro-inflammatory and changes in airway responsiveness that characterizes the atopic asthmatic state. We previously demonstrated that human airway smooth mus
Externí odkaz:
https://doaj.org/article/88969ffda7f34702a9c62d9310c7c405
Autor:
Naresh Singh Redhu, Ali Saleh, Lianyu Shan, William T Gerthoffer, Sam K Kung, Andrew J Halayko, Bouchaib Lamkhioued, Abdelilah S Gounni
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6153 (2009)
BACKGROUND:The high affinity IgE receptor (FcepsilonRI) is a crucial structure for IgE-mediated allergic reactions. We have previously demonstrated that human airway smooth muscle (ASM) cells express the tetrameric (alphabetagamma2) FcepsilonRI, and
Externí odkaz:
https://doaj.org/article/febe1ff7ccd742c3a3f4595c86f6a9ca