Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Abdelilah Aboussekhra"'
Autor:
Syed S. Islam, Falah H. Al-Mohanna, Iman M. Yousef, Ismail A. Al-Badawi, Abdelilah Aboussekhra
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-19 (2024)
Abstract The primary site of metastasis for epithelial ovarian cancer (EOC) is the peritoneum, and it occurs through a multistep process that begins with adhesive contacts between cancer cells and mesothelial cells. Despite evidence that Notch signal
Externí odkaz:
https://doaj.org/article/1b5aa2e4d5cf4edb94b74be84d610dbf
Autor:
Syed S. Islam, Taher Al-Tweigeri, Layla Al-Harbi, Shafat Ujjahan, Maha Al-Mozaini, Asma Tulbah, Abdelilah Aboussekhra
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Breast cancer (BC) patient who receives chemotherapy for an extended length of time may experience profound repercussions in terms of metastases and clinical outcomes due to the involvement of the epithelial-to-mesenchymal transition (EMT) m
Externí odkaz:
https://doaj.org/article/36a646056f724073be5011d02cb36d13
Publikováno v:
Translational Oncology, Vol 37, Iss , Pp 101780- (2023)
Background: Radiotherapy is an important therapeutic strategy for breast cancer patients through reducing the chances of recurrence and metastasis, which are fueled by cancer-associated fibroblasts (CAFs). Thereby, we addressed here the effect of var
Externí odkaz:
https://doaj.org/article/c703bcec4a8d4aba89c9399fac13a91a
Autor:
Wafaa A. Aljagthmi, Manal A. Alasmari, Maha H. Daghestani, Layla A. Al-Kharashi, Falah H. Al-Mohanna, Abdelilah Aboussekhra
Publikováno v:
Cells, Vol 13, Iss 8, p 680 (2024)
Decorin (DCN), a member of the small leucine-rich proteoglycan gene family, is secreted from stromal fibroblasts with non-cell-autonomous anti-breast-cancer effects. Therefore, in the present study, we sought to elucidate the function of decorin in b
Externí odkaz:
https://doaj.org/article/89be0adfe4d24b8fa823e54841af33bf
Autor:
Mai Al-Mohanna, Noura N. Alraouji, Samiah A. Alhabardi, Falah Al-Mohanna, Basem Al-Otaibi, Ibrahim Al-Jammaz, Abdelilah Aboussekhra
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract Anaplastic thyroid carcinoma (ATC) is the rarest type of thyroid cancer, but is the common cause of death from these tumors. The aggressive behavior of ATC makes it resistant to the conventional therapeutic approaches. Thus, the present stud
Externí odkaz:
https://doaj.org/article/3d1fa440d48a4abe8f5cf6125e6bb807
Publikováno v:
Translational Oncology, Vol 35, Iss , Pp 101721- (2023)
Background: Active breast cancer-associated fibroblasts (CAFs) promote tumor growth and spread, and like tumor cells they are also heterogeneous with various molecular sub-types and different pro-tumorigenic capacities. Methods: We have used immunobl
Externí odkaz:
https://doaj.org/article/e116e36c21ad446888b7b4bef7958231
Autor:
Syed S. Islam, Khawlah Qassem, Shafiqul Islam, Rashed R. Parag, Mohammed Z. Rahman, Walid A. Farhat, Herman Yeger, Abdelilah Aboussekhra, Bedri Karakas, Abu Shadat M. Noman
Publikováno v:
Cell Death and Disease, Vol 13, Iss 8, Pp 1-13 (2022)
Abstract Keap1 mutations regulate Nrf2 activity and lead to chemoresistance in cancers. Yet the underlying molecular mechanisms of chemoresistance are poorly explored. By focusing and genotyping head and neck squamous cell carcinoma (HNSCC) that had
Externí odkaz:
https://doaj.org/article/63807b26d5284eb1ba2fb9405a2b8a18
Autor:
Taher Al-Tweigeri, Noura N. AlRaouji, Asma Tulbah, Maria Arafah, Mouad Aboussekhra, Falah Al-Mohanna, Ahmed Mostafa Gad, Abdelmonneim M. Eldali, Tusneem A. Elhassan, Abdelilah Aboussekhra
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-15 (2022)
Abstract Background Locally advanced breast cancer (LABC), the most aggressive form of the disease, is a serious threat for women's health worldwide. The AU-rich RNA-binding factor 1 (AUF1) promotes the formation of chemo-resistant breast cancer stem
Externí odkaz:
https://doaj.org/article/fdfaf012f7d645afbcc26f3df30413d9
Publikováno v:
Cancers, Vol 15, Iss 20, p 5006 (2023)
Mutations in Keap1/Nrf2 in head and neck cancer result in abnormal cell growth. Progenitor cells, bulk tumor cells, and head and neck cancer stem cells (HN-CSCs) may all harbor these mutations. Nevertheless, whether Keap1/Nrf2 mutations in HN-CSCs ha
Externí odkaz:
https://doaj.org/article/5adf59c1115d491bb9e6db87e6c7f0ac
Autor:
Layla A. Al-Kharashi, Asma Tulbah, Maria Arafah, Abdelmonneim M. Eldali, Taher Al-Tweigeri, Abdelilah Aboussekhra
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundActive breast cancer-associated fibroblasts (CAFs) play a leading role in breast carcinogenesis through promoting angiogenesis and resistance to therapy. Consequently, these active stromal cells have significant influence on patient outcome
Externí odkaz:
https://doaj.org/article/f60d4db3c00e44c5922321049ef9a011