Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Abdelhay, Boulahtouf"'
Autor:
Jakub Gruszczyk, Loïc Grandvuillemin, Josephine Lai-Kee-Him, Matteo Paloni, Christos G. Savva, Pierre Germain, Marina Grimaldi, Abdelhay Boulahtouf, Hok-Sau Kwong, Julien Bous, Aurélie Ancelin, Cherine Bechara, Alessandro Barducci, Patrick Balaguer, William Bourguet
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Aryl hydrocarbon receptor (AHR) is a sensor of the chemical environment including pollutants, diet components and metabolites. Here, authors determine the structure of the indirubin-bound AHR cytosolic complex providing mechanistic insights into liga
Externí odkaz:
https://doaj.org/article/ada9a76084db488fb5e5963b48693d01
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionThe action of environmental steroids on the human glucocorticoid receptor (hGR) has been pointed out with the risk to impair physiological immune and metabolic processes regulated by this nuclear receptor. However, there is still a lack o
Externí odkaz:
https://doaj.org/article/a873ee93e8f2427ca388364f44e088f4
Autor:
Natacha Roux, Saori Miura, Mélanie Dussenne, Yuki Tara, Shu-hua Lee, Simon de Bernard, Mathieu Reynaud, Pauline Salis, Agneesh Barua, Abdelhay Boulahtouf, Patrick Balaguer, Karine Gauthier, David Lecchini, Yann Gibert, Laurence Besseau, Vincent Laudet
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112661- (2023)
Summary: Most marine organisms have a biphasic life cycle during which pelagic larvae transform into radically different juveniles. In vertebrates, the role of thyroid hormones (THs) in triggering this transition is well known, but how the morphologi
Externí odkaz:
https://doaj.org/article/eaaaa56e65d6463498b1511cc2a8f5b7
Autor:
Aurélien Linares, Said Assou, Marion Lapierre, Erwan Thouennon, Céline Duraffourd, Carole Fromaget, Abdelhay Boulahtouf, Gao Tian, Jiafu Ji, Ozgur Sahin, Eric Badia, Nathalie Boulle, Vincent Cavaillès
Publikováno v:
Molecular Oncology, Vol 13, Iss 7, Pp 1534-1547 (2019)
Estrogens play a pivotal role in breast cancer etiology, and endocrine therapy remains the main first line treatment for estrogen receptor‐alpha (ERα)‐positive breast cancer. ER are transcription factors whose activity is finely regulated by var
Externí odkaz:
https://doaj.org/article/84f9cc8688a84b75ba3abe036c5acfff
Autor:
Nicolas Creusot, Clémentine Garoche, Marina Grimaldi, Abdelhay Boulahtouf, Barbara Chiavarina, William Bourguet, Patrick Balaguer
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
The nuclear receptor pregnane X receptor (PXR) is a ligand-dependent transcription factor that regulates genes involved in xenobiotic metabolism in mammals. Many studies suggest that PXR may play a similar role in fish. The interaction of human PXR (
Externí odkaz:
https://doaj.org/article/edbea471fdeb425ab0eb002a2253b69d
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
To characterize human nuclear receptor (NR) specificity of synthetic pharmaceutical chemicals we established stable cell lines expressing the ligand binding domains (LBDs) of human FXR, LXRα, LXRβ, CAR, and RORγ fused to the yeast GAL4 DNA binding
Externí odkaz:
https://doaj.org/article/4b21079a072545a4930acc0cdd800cab
Autor:
Nicolas Creusot, Matthieu Gassiot, Elina Alaterre, Barbara Chiavarina, Marina Grimaldi, Abdelhay Boulahtouf, Lucia Toporova, Sabine Gerbal-Chaloin, Martine Daujat-Chavanieu, Alice Matheux, Roger Rahmani, Céline Gongora, Alexandre Evrard, Philippe Pourquier, Patrick Balaguer
Publikováno v:
Cells, Vol 9, Iss 7, p 1641 (2020)
The human pregnane X receptor (hPXR) is activated by a large set of endogenous and exogenous compounds and plays a critical role in the control of detoxifying enzymes and transporters regulating liver and gastrointestinal drug metabolism and clearanc
Externí odkaz:
https://doaj.org/article/6365fd85f5794b0ba04d7fe248f966dc
Autor:
Hadjer Dellal, Abdelhay Boulahtouf, Elina Alaterre, Alice Cuenant, Marina Grimaldi, William Bourguet, Céline Gongora, Patrick Balaguer, Philippe Pourquier
Publikováno v:
Cells, Vol 9, Iss 6, p 1469 (2020)
Prostate cancer is the most commonly diagnosed malignancy in men. Its growth mainly relies on the activity of the androgen receptor (AR), justifying the use of androgen deprivation therapy as a gold standard treatment for the metastatic disease. Inhi
Externí odkaz:
https://doaj.org/article/6f17935324c14c019d86b52251621318
Autor:
Marina Grimaldi, Abdelhay Boulahtouf, Corinne Prévostel, Alain Thierry, Patrick Balaguer, Philippe Blache
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
A constitutive activation of the Wnt/β-catenin pathway is an initiating event in colon carcinogenesis. We developed colon cancer cells models that highlight the non-selectivity of previously described inhibitors of the Wnt pathway and we propose our
Externí odkaz:
https://doaj.org/article/254657234d874a2b81584718e9e78283
Autor:
Clémentine Garoche, Marina Grimaldi, Erwan Michelin, Abdelhay Boulahtouf, Anthony Marconi, François Brion, Patrick Balaguer, Selim Aït-Aïssa
Publikováno v:
Toxicology in Vitro. 88:105554
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a951906b50c5cc6891664e1382291c49
https://doi.org/10.1016/j.tiv.2023.105554
https://doi.org/10.1016/j.tiv.2023.105554