Výsledky vyhledávání - "Abdelhalim I. Elassasy"

Akademický článek

Fabrication of novel elastosomes for boosting the transdermal delivery of diacerein: statistical optimization, ex-vivo permeation, in-vivo skin deposition and pharmacokinetic assessment compared to oral formulation

Autor: Diana E. Aziz, Aly A. Abdelbary, Abdelhalim I. Elassasy

Publikováno v: Drug Delivery, Vol 25, Iss 1, Pp 815-826 (2018)

Diacerein (DCN) is a hydrophobic osteoarthritis (OA) drug with short half-life and low oral bioavailability. Furthermore, DCN oral administration is associated with diarrhea which represents obstacle against its oral use. Hence, this article aimed at

Externí odkaz: https://doaj.org/article/dd00f68e22344d9ea54b62771e32bd40

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Akademický článek

Solutol HS15 based binary mixed micelles with penetration enhancers for augmented corneal delivery of sertaconazole nitrate: optimization, in vitro, ex vivo and in vivo characterization

Autor: Nihal Farid Younes, Sally Adel Abdel-Halim, Abdelhalim I. Elassasy

Publikováno v: Drug Delivery, Vol 25, Iss 1, Pp 1706-1717 (2018)

Keratomycosis is a serious corneal disease that can cause a permanent visual disability if not treated effectively. Sertaconazole nitrate (STZ), a novel broad spectrum antifungal drug, was suggested as a promising treatment. However, its utility in t

Externí odkaz: https://doaj.org/article/dcf84e17e596415e9122268dcfd62e93

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Corneal targeted Sertaconazole nitrate loaded cubosomes: Preparation, statistical optimization, in vitro characterization, ex vivo permeation and in vivo studies

Autor: Abdelhalim I. Elassasy, Nihal Farid Younes, Sally A. Abdel-Halim

Publikováno v: International Journal of Pharmaceutics. 553:386-397

Sertaconazole nitrate (STZ) is a poorly soluble antifungal drug commonly used for treating fungal skin infections. Introducing it as a new treatment option for the management of fungal keratitis, requires the development of a delivery system capable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b3469ace5bb07f42b2e887c8b589393
https://doi.org/10.1016/j.ijpharm.2018.10.057

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Implementing Central Composite Design for Developing Transdermal Diacerein-Loaded Niosomes: Ex vivo Permeation and In vivo Deposition

Autor: Abdelhalim I. Elassasy, Diana E. Aziz, Aly A. Abdelbary

Publikováno v: Current Drug Delivery

Background: Niosomes are surfactant-based vesicular nanosystems that proved their efficien-cy in transdermal delivery by overcoming skin inherent anatomic barrier; startum corneum. Central com-posite design is an efficient tool for developing and opt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66bf19b5c50befeb38713512f51e09a0
https://doi.org/10.2174/1567201815666180619105419

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Investigating superiority of novel bilosomes over niosomes in the transdermal delivery of diacerein:in vitrocharacterization,ex vivopermeation andin vivoskin deposition study

Autor: Aly A. Abdelbary, Diana E. Aziz, Abdelhalim I. Elassasy

Publikováno v: Journal of Liposome Research. 29:73-85

Skin is considered the most accessible organ of the body because of its underlying capillary network. However, stratum corneum (SC), the upper most layer of skin, represents major diffusional barrier for most drugs. Hence, the use of edge activators

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72241ff987911528c3686e918615087d
https://doi.org/10.1080/08982104.2018.1430831

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Autor: Aly A. Abdelbary, Diana E. Aziz, Abdelhalim I. Elassasy

Publikováno v: Drug Delivery, Vol 25, Iss 1, Pp 815-826 (2018)
Drug Delivery

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd3aebde3dfbf994822563565e77d25e
https://doaj.org/article/dd00f68e22344d9ea54b62771e32bd40

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Effect of fixed aqueous layer thickness of polymeric stabilizers on zeta potential and stability of aripiprazole nanosuspensions

Autor: Xiaoling Li, Aly A. Abdelbary, Bhaskara R. Jasti, Abdelhalim I. Elassasy, Mohamed A. El-Nabarawi

Publikováno v: Pharmaceutical Development and Technology. 18:730-735

The aim of this study was to evaluate the effect of the thickness of adsorbed polymer layer (also known as Fixed Aqueous Layer Thickness, FALT) of polymeric stabilizers on zeta potential and stability of nanoparticles in a suspension. Aripiprazole, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e9d45629d241fc5c8efc15de7a26c9
https://doi.org/10.3109/10837450.2012.727001

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Comparison of nanomilling and coprecipitation on the enhancement of in vitro dissolution rate of poorly water-soluble model drug aripiprazole

Autor: Mohamed A. El-Nabarawi, Aly A. Abdelbary, Abdelhalim I. Elassasy, Bhaskara R. Jasti, Xiaoling Li

Publikováno v: Pharmaceutical development and technology. 19(4)

The aim of this study was to evaluate the effect of coprecipitation and nanomilling on the crystallinity of a model drug, aripiprazole and evaluate the in vitro dissolution rate (IDR). Aripiprazole compositions were prepared by physical mixing, copre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd0efd214fb302ecc9b57b5db05e5898
https://pubmed.ncbi.nlm.nih.gov/23731085

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