Discovery and Anticancer Screening of Novel Oxindole-Based Derivative Bearing Pyridyl Group as Potent and Selective Dual FLT3/CDK2 Kinase Inhibitor.

Autor: Soudi A; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt., Bender O; Biotechnology Institute, Ankara University, Ankara 06135, Turkey., Celik I; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Erciyes University, Kayseri 38280, Turkey.; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, 06120 Halle, Germany., El-Hafeez AAA; Pharmacology and Experimental Oncology Unit, Department of Cancer Biology, National Cancer Institute, Cairo University, Cairo 11796, Egypt., Dogan R; Biotechnology Institute, Ankara University, Ankara 06135, Turkey., Atalay A; Biotechnology Institute, Ankara University, Ankara 06135, Turkey., Elkaeed EB; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh 13713, Saudi Arabia., Alsfouk AA; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia., Abdelhafez EMN; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt., Aly OM; Department of Medicinal Chemistry, Faculty of Pharmacy, Port Said University, Port Said 42511, Egypt., Sippl W; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, 06120 Halle, Germany., Ali TFS; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.

Publikováno v: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2024 May 20; Vol. 17 (5). Date of Electronic Publication: 2024 May 20.

Novel quinoline/thiazinan-4-one hybrids; design, synthesis, and molecular docking studies as potential anti-bacterial candidates against MRSA.

Autor: Mohamed AH; Chemistry Department, Faculty of Science, Minia University El-Minia 61519 Egypt asmaa.hamouda@mu.edu.eg sara.ahmed@mu.edu.eg ashrafaly63@yahoo.com ashraf.shehata@mu.edu.eg alaahassan2001@mu.edu.eg esraamah33@gmail.com., Mostafa SM; Chemistry Department, Faculty of Science, Minia University El-Minia 61519 Egypt asmaa.hamouda@mu.edu.eg sara.ahmed@mu.edu.eg ashrafaly63@yahoo.com ashraf.shehata@mu.edu.eg alaahassan2001@mu.edu.eg esraamah33@gmail.com., Aly AA; Chemistry Department, Faculty of Science, Minia University El-Minia 61519 Egypt asmaa.hamouda@mu.edu.eg sara.ahmed@mu.edu.eg ashrafaly63@yahoo.com ashraf.shehata@mu.edu.eg alaahassan2001@mu.edu.eg esraamah33@gmail.com., Hassan AA; Chemistry Department, Faculty of Science, Minia University El-Minia 61519 Egypt asmaa.hamouda@mu.edu.eg sara.ahmed@mu.edu.eg ashrafaly63@yahoo.com ashraf.shehata@mu.edu.eg alaahassan2001@mu.edu.eg esraamah33@gmail.com., Osman EM; Chemistry Department, Faculty of Science, Minia University El-Minia 61519 Egypt asmaa.hamouda@mu.edu.eg sara.ahmed@mu.edu.eg ashrafaly63@yahoo.com ashraf.shehata@mu.edu.eg alaahassan2001@mu.edu.eg esraamah33@gmail.com., Nayl AA; Department of Chemistry, College of Science, Jouf University Sakaka 72341 Aljouf Saudi Arabia aanayel@ju.edu.sa., Brown AB; Chemistry Department, Florida Institute of Technology Melbourne FL USA., Abdelhafez EMN; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University 61519 Minia Egypt.

Publikováno v: RSC advances [RSC Adv] 2023 May 12; Vol. 13 (21), pp. 14631-14640. Date of Electronic Publication: 2023 May 12 (Print Publication: 2023).

Potential protective effect of 3,3'-methylenebis(1-ethyl-4-hydroxyquinolin-2(1H)-one) against bleomycin-induced lung injury in male albino rat via modulation of Nrf2 pathway: biochemical, histological, and immunohistochemical study.

Autor: Hafez SMNA; Department of Histology and Cell Biology, Faculty of Medicine, Minia University, Minia, 61111, Egypt. sara.abdelhafez@mu.edu.eg., Saber EA; Department of Histology and Cell Biology, Faculty of Medicine, Minia University, Minia, 61111, Egypt.; Delegated to Deraya University, New Minia City, Minia, Egypt., Aziz NM; Delegated to Deraya University, New Minia City, Minia, Egypt.; Department of Medical Physiology, Faculty of Medicine, Minia University, Minia, Egypt., Kamel MY; Department of Pharmacology, Faculty of Medicine, Minia University, Minia, Egypt., Aly AA; Department of Chemistry, Faculty of Science, Minia University, Minia, Egypt., Abdelhafez EMN; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt., Ibrahim MFG; Department of Histology and Cell Biology, Faculty of Medicine, Minia University, Minia, 61111, Egypt.

Publikováno v: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2023 Apr; Vol. 396 (4), pp. 771-788. Date of Electronic Publication: 2022 Dec 08.

Metal complexes of thiosemicarbazones derived by 2-quinolones with Cu(I), Cu(II) and Ni(II); Identification by NMR, IR, ESI mass spectra and in silico approach as potential tools against SARS-CoV-2.

Autor: Aly AA; Chemistry Department, Faculty of Science, Minia University, El-Minia 61519, Egypt., Abdallah EM; Chemistry Department, Faculty of Science, Minia University, El-Minia 61519, Egypt., Ahmed SA; Chemistry Department, Faculty of Science, Minia University, El-Minia 61519, Egypt., Rabee MM; Chemistry Department, Faculty of Science, Minia University, El-Minia 61519, Egypt., Abdelhafez EMN; Medicinal Chemistry, Department, Faculty of Pharmacy, Minia University, El-Minia 61519 Egypt.

Publikováno v: Journal of molecular structure [J Mol Struct] 2022 Oct 05; Vol. 1265, pp. 133480. Date of Electronic Publication: 2022 Jun 09.

Design, Synthesis, and Molecular Docking of Paracyclophanyl-Thiazole Hybrids as Novel CDK1 Inhibitors and Apoptosis Inducing Anti-Melanoma Agents.

Autor: Aly AA; Department of Chemistry, Faculty of Science, Minia University, El Minia 61519, Egypt., Bräse S; Institute of Organic Chemistry, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany.; Institute of Biological and Chemical Systems-Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen, Germany., Hassan AA; Department of Chemistry, Faculty of Science, Minia University, El Minia 61519, Egypt., Mohamed NK; Department of Chemistry, Faculty of Science, Minia University, El Minia 61519, Egypt., El-Haleem LEA; Institute of Organic Chemistry, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany.; Institute of Biological and Chemical Systems-Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen, Germany., Nieger M; Department of Chemistry, University of Helsinki, P.O. Box 55 (A. I. Virtasen aukio I), 00014 Helsinki, Finland., Morsy NM; National Research Centre, Organometallic and Organometalloid Chemistry Department, Dokki, Cairo 12622, Egypt., Alshammari MB; College of Sciences and Humanities, Prince Sattam bin Abdulaziz University, Alkharj 11942, Saudi Arabia., Ibrahim MAA; Department of Chemistry, Faculty of Science, Minia University, El Minia 61519, Egypt., Abdelhafez EMN; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, El Minia 61519, Egypt.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2020 Nov 27; Vol. 25 (23). Date of Electronic Publication: 2020 Nov 27.