Losmapimod ameliorates doxorubicin-induced cardiotoxicity through attenuating senescence and inflammatory pathways.

Autor: Dabour MS; Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, MN 55455, USA; Department of Clinical Pharmacy, Faculty of Pharmacy, Tanta University, Egypt. Electronic address: dabou003@umn.edu., Abdelgawad IY; Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, MN 55455, USA. Electronic address: abdel217@umn.edu., Sadaf B; Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, MN 55455, USA; Faculty of Pharmacy, the University of Lahore, Lahore, Pakistan. Electronic address: bsadaf@umn.edu., Daniel MR; Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, MN 55455, USA. Electronic address: dani0947@umn.edu., Grant MKO; Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, MN 55455, USA. Electronic address: grant032@umn.edu., Seelig D; Department of Veterinary Clinical Sciences, University of Minnesota, College of Veterinary Medicine, Saint Paul, MN 55108, USA. Electronic address: dseelig@umn.edu., Zordoky BN; Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, MN 55455, USA. Electronic address: zordo001@umn.edu.

Publikováno v: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Oct; Vol. 179, pp. 117288. Date of Electronic Publication: 2024 Aug 14.

Canagliflozin mitigates carfilzomib-induced endothelial apoptosis via an AMPK-dependent pathway.

Autor: Dabour MS; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA; Department of Clinical Pharmacy, Faculty of Pharmacy, Tanta University, 31111 Tanta, Egypt., Abdelgawad IY; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA., Grant MKO; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA., El-Sawaf ES; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA; Department of Pharmacology, Toxicology, and Biochemistry, Faculty of Pharmacy, Future University in Egypt, Cairo, Egypt., Zordoky BN; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: zordo001@umn.edu.

Publikováno v: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2023 Aug; Vol. 164, pp. 114907. Date of Electronic Publication: 2023 May 27.

EA.hy926 Cells and HUVECs Share Similar Senescence Phenotypes but Respond Differently to the Senolytic Drug ABT-263.

Autor: Abdelgawad IY; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA., Agostinucci K; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA., Ismail SG; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA., Grant MKO; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA., Zordoky BN; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.

Publikováno v: Cells [Cells] 2022 Jun 21; Vol. 11 (13). Date of Electronic Publication: 2022 Jun 21.

Juvenile exposure to doxorubicin alters the cardiovascular response to adult-onset psychosocial stress in mice.

Autor: Grant MKO; Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, MN, USA., Razzoli M; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, USA., Abdelgawad IY; Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, MN, USA., Mansk R; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, USA., Seelig D; Department of Veterinary Clinical Sciences, University of Minnesota College of Veterinary Medicine, St. Paul, MN, USA., Bartolomucci A; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, USA., Zordoky BN; Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, MN, USA.

Publikováno v: Stress (Amsterdam, Netherlands) [Stress] 2022 Jan; Vol. 25 (1), pp. 291-304.

Molecular mechanisms and cardiovascular implications of cancer therapy-induced senescence.

Autor: Abdelgawad IY; Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, MN 55455, USA., Sadak KT; Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA; University of Minnesota Masonic Children's Hospital, Minneapolis, MN 55455, USA; University of Minnesota Masonic Cancer Center, Minneapolis, MN 55455, USA., Lone DW; University of Minnesota Masonic Children's Hospital, Minneapolis, MN 55455, USA., Dabour MS; Clinical Pharmacy Department, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt., Niedernhofer LJ; Institute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Medical School, Minneapolis, MN 55455, USA., Zordoky BN; Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, MN 55455, USA. Electronic address: zordo001@umn.edu.

Publikováno v: Pharmacology & therapeutics [Pharmacol Ther] 2021 May; Vol. 221, pp. 107751. Date of Electronic Publication: 2020 Dec 01.