Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Abdelfattah Faouzi"'
Autor:
Rohini S. Ople, Nokomis Ramos-Gonzalez, Qiongyu Li, Briana L. Sobecks, Deniz Aydin, Alexander S. Powers, Abdelfattah Faouzi, Benjamin J. Polacco, Sarah M. Bernhard, Kevin Appourchaux, Sashrik Sribhashyam, Shainnel O. Eans, Bowen A. Tsai, Ron O. Dror, Balazs R. Varga, Haoqing Wang, Ruth Hüttenhain, Jay P. McLaughlin, Susruta Majumdar
Publikováno v:
ACS Central Science, Vol 10, Iss 8, Pp 1490-1503 (2024)
Externí odkaz:
https://doaj.org/article/85002e8675b5414c9f0b93723260a5ff
Autor:
Srijita Bhowmik, Juraj Galeta, Václav Havel, Melissa Nelson, Abdelfattah Faouzi, Benjamin Bechand, Mike Ansonoff, Tomas Fiala, Amanda Hunkele, Andrew C. Kruegel, John. E. Pintar, Susruta Majumdar, Jonathan A. Javitch, Dalibor Sames
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Mitragynine (MG) is an indole alkaloid from kratom plant that binds opioid receptors and as such presents a scaffold for the development of atypical opioid receptor modulators. Here, the authors report a synthetic method for selective functionalizati
Externí odkaz:
https://doaj.org/article/ea38af09c9b14aa088b91f729a3dae52
Autor:
Rajendra Uprety, Tao Che, Saheem A Zaidi, Steven G Grinnell, Balázs R Varga, Abdelfattah Faouzi, Samuel T Slocum, Abdullah Allaoa, András Varadi, Melissa Nelson, Sarah M Bernhard, Elizaveta Kulko, Valerie Le Rouzic, Shainnel O Eans, Chloe A Simons, Amanda Hunkele, Joan Subrath, Ying Xian Pan, Jonathan A Javitch, Jay P McLaughlin, Bryan L Roth, Gavril W Pasternak, Vsevolod Katritch, Susruta Majumdar
Publikováno v:
eLife, Vol 10 (2021)
Controlling receptor functional selectivity profiles for opioid receptors is a promising approach for discovering safer analgesics; however, the structural determinants conferring functional selectivity are not well understood. Here, we used crystal
Externí odkaz:
https://doaj.org/article/dc31183697a3454e95268139bbe3d9fd
Publikováno v:
Pharmaceuticals, Vol 14, Iss 2, p 109 (2021)
The complexity and organization of the central nervous system (CNS) is widely modulated by the presence of the blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (BCSFB), which both act as biochemical, dynamic obstacles impeding
Externí odkaz:
https://doaj.org/article/146a822c665d48789b6713b1ac857943
Publikováno v:
Molecules, Vol 25, Iss 18, p 4257 (2020)
Achieving effective pain management is one of the major challenges associated with modern day medicine. Opioids, such as morphine, have been the reference treatment for moderate to severe acute pain not excluding chronic pain modalities. Opioids act
Externí odkaz:
https://doaj.org/article/defe553596a944b48ee38b67c14f5567
Autor:
Abdelfattah Faouzi, Haoqing Wang, Saheem A. Zaidi, Jeffrey F. DiBerto, Tao Che, Qianhui Qu, Michael J. Robertson, Manish K. Madasu, Amal El Daibani, Balazs R. Varga, Tiffany Zhang, Claudia Ruiz, Shan Liu, Jin Xu, Kevin Appourchaux, Samuel T. Slocum, Shainnel O. Eans, Michael D. Cameron, Ream Al-Hasani, Ying Xian Pan, Bryan L. Roth, Jay P. McLaughlin, Georgios Skiniotis, Vsevolod Katritch, Brian K. Kobilka, Susruta Majumdar
Publikováno v:
Nature.
Mu opioid receptor (µOR) agonists like fentanyl have long been used for pain management, but are considered a major public health concern due to their adverse side effects, including lethal overdose.
Autor:
Abdelfattah Faouzi, Hye Jean Yoon, Rajendra Uprety, John M. Streicher, Lakshmi A. Devi, Susruta Majumdar, Michael Ansonoff, Ivone Gomes, Nicolas Massaly, Tiffany Zhang, Valerie Le Rouzic, Attila Keresztes, Jose A. Morón, Ying-Xian Pan, Achla Gupta, Abdullah Allaoa, John E. Pintar
Publikováno v:
J Med Chem
In this work, we studied a series of carfentanyl amide-based opioid derivatives targeting the mu opioid receptor (μOR) and the delta opioid receptor (δOR) heteromer as a credible novel target in pain management therapy. We identified a lead compoun
Autor:
Samuel T. Slocum, Vsevolod Katritch, Rajendra Uprety, Joan J. Subrath, Jay P. McLaughlin, Gavril W. Pasternak, Ying Xian Pan, Amanda Hunkele, Valerie Le Rouzic, Melissa Nelson, Steven G. Grinnell, Abdelfattah Faouzi, András Váradi, Saheem A. Zaidi, Bryan L. Roth, Shainnel O. Eans, Balázs Varga, Elizaveta Kulko, Abdullah Allaoa, Tao Che, Susruta Majumdar, Sarah M Bernhard, Jonathan A. Javitch, Chloe A. Simons
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Controlling receptor functional selectivity profiles for opioid receptors is a promising approach for discovering safer analgesics; however, the structural determinants conferring functional selectivity are not well understood. Here, we used crystal
Autor:
Abdelfattah Faouzi, Benjamin Bechand, Susruta Majumdar, Jonathan A. Javitch, Andrew C. Kruegel, Juraj Galeta, Tomas Fiala, Srijita Bhowmik, Vaclav Havel, Dalibor Sames, Mike Ansonoff, John E. Pintar, Amanda Hunkele, Melissa Nelson
Publikováno v:
Nature Communications
Nature Communications, 12 (1)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, 12 (1)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Mitragynine (MG) is the most abundant alkaloid component of the psychoactive plant material “kratom”, which according to numerous anecdotal reports shows efficacy in self-medication for pain syndromes, depression, anxiety, and substance use disor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9de81b7aacd8b411234961746c5ac2e
Autor:
Gavril W. Pasternak, Abdelfattah Faouzi, Bryan L. Roth, Amanda Hunkele, Steven G. Grinnell, Susruta Majumdar, Valerie Le Rouzic, Melissa Nelson, Sarah M Bernhard, Chloe A. Simons, Shainnel O. Eans, Samuel T. Slocum, Rajendra Uprety, Joan J. Subrath, András Váradi, Tao Che, Ying Xian Pan, Jonathan A. Javitch, Elizaveta Kulko, Vsevolod Katritch, Abdullah Allaoa, Saheem A. Zaidi, Balázs Varga, Jay P. McLaughlin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acf306e63c447f91f658560d8a55c64b
https://doi.org/10.7554/elife.56519.sa2
https://doi.org/10.7554/elife.56519.sa2