Pyrrolizine-5-carboxamides: Exploring the impact of various substituents on anti-inflammatory and anticancer activities

Autor: Gouda Ahmed M., Abdelazeem Ahmed H., Abdalla Ashraf N., Ahmed Muhammad

Publikováno v: Acta Pharmaceutica, Vol 68, Iss 3, Pp 251-273 (2018)

Towards optimization of the pyrrolizine-5-carboxamide scaffold, a novel series of six derivatives (4a-c and 5a-c) was prepared and evaluated for their anti-inflammatory, analgesic and anticancer activities. The (EZ)-7-cyano-6-((4-hydroxybenzylidene)a

Externí odkaz: https://doaj.org/article/1c40235d4cb3418397e9399d19c5e59f

Covalent small-molecule inhibitors of SARS-CoV-2 Mpro: Insights into their design, classification, biological activity, and binding interactions.

Autor: Shawky AM; Science and Technology Unit (STU), Umm Al-Qura University, Makkah, 21955, Saudi Arabia., Almalki FA; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Umm Al-Qura University, Makkah, 21955, Saudi Arabia., Alzahrani HA; Applied Medical Science College, Medical Laboratory Technology Department, Northern Border University, Arar, Saudi Arabia., Abdalla AN; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Umm Al-Qura University, Makkah, 21955, Saudi Arabia; Department of Pharmacology and Toxicology, Medicinal And Aromatic Plants Research Institute, National Center for Research, Khartoum, 2404, Sudan., Youssif BGM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt. Electronic address: bgyoussif2@gmail.com., Ibrahim NA; Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt., Gamal M; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt., El-Sherief HAM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, Minia, Egypt., Abdel-Fattah MM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt., Hefny AA; Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt; School of Pharmacy, University of Waterloo, Kitchener, Ontario, N2G 1C5, Canada., Abdelazeem AH; Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt; Pharmacy Department, College of Pharmacy, Nursing and Medical Sciences, Riyadh Elm University, Riyadh, 11681, Saudi Arabia., Gouda AM; Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt. Electronic address: ahmed.gouda@pharm.bsu.edu.eg.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2024 Nov 05; Vol. 277, pp. 116704. Date of Electronic Publication: 2024 Aug 08.

Does sequential examination under anaesthesia provide a reliable method to determine a management plan for unstable lateral compression pelvic ring injuries? a prospective study.

Autor: Shawky MA; Pelvic Trauma and Arthroplasty Unit, Department of Orthopaedics and Traumatology, Kasr-AlAiny Hospital, Cairo University, 12 Al-Saraya Street, El Manial, Cairo, Egypt. mostafa.a.shawky.mohamed@gmail.com., Abdelazeem AH; Pelvic Trauma and Arthroplasty Unit, Department of Orthopaedics and Traumatology, Kasr-AlAiny Hospital, Cairo University, 12 Al-Saraya Street, El Manial, Cairo, Egypt., Abdel-Kader KF; Pelvic Trauma and Arthroplasty Unit, Department of Orthopaedics and Traumatology, Kasr-AlAiny Hospital, Cairo University, 12 Al-Saraya Street, El Manial, Cairo, Egypt., Mohammad MM; Pelvic Trauma and Arthroplasty Unit, Department of Orthopaedics and Traumatology, Kasr-AlAiny Hospital, Cairo University, 12 Al-Saraya Street, El Manial, Cairo, Egypt., Azzam AH; Pelvic Trauma and Arthroplasty Unit, Department of Orthopaedics and Traumatology, Kasr-AlAiny Hospital, Cairo University, 12 Al-Saraya Street, El Manial, Cairo, Egypt.

Publikováno v: European journal of orthopaedic surgery & traumatology : orthopedie traumatologie [Eur J Orthop Surg Traumatol] 2024 Oct; Vol. 34 (7), pp. 3455-3464. Date of Electronic Publication: 2023 Jul 05.

Assessment of Monitoring and Management Practices of Antipsychotic-Induced Hyperprolactinemia at a Medical City in Riyadh, Saudi Arabia: A Retrospective Cohort Study.

Autor: Alshabeeb ZH; Psychiatric Clinical Pharmacy Services; Erada Complex for Mental Health, Dammam, Saudi Arabia, Alsuwayni B; Ambulatory Care Clinical Pharmacy Services, King Saud Medical City, Riyadh, Saudi Arabia, Alshargi O; College of Pharmacy, Riyadh Elm University, Riyadh 11681, Saudi Arabia, Abdelazeem AH; College of Pharmacy, Riyadh Elm University, Riyadh 11681, Saudi Arabia; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt

Publikováno v: Current drug safety [Curr Drug Saf] 2024 Mar 12. Date of Electronic Publication: 2024 Mar 12.

New 1,2,4-oxadiazole/pyrrolidine hybrids as topoisomerase IV and DNA gyrase inhibitors with promising antibacterial activity.

Autor: Frejat FOA; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, People's Republic of China.; Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Zhengzhou, People's Republic of China., Cao Y; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, People's Republic of China.; Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Zhengzhou, People's Republic of China., Wang L; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, People's Republic of China.; Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Zhengzhou, People's Republic of China., Zhai H; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, People's Republic of China.; Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Zhengzhou, People's Republic of China., Abdelazeem AH; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.; Pharmacy Department, College of Pharmacy, Riyadh Elm University, Riyadh, Saudi Arabia., Gomaa HAM; Pharmacology Department, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia., Youssif BGM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt., Wu C; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, People's Republic of China.; Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Zhengzhou, People's Republic of China.

Publikováno v: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2022 Jul; Vol. 355 (7), pp. e2100516. Date of Electronic Publication: 2022 Apr 01.