Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Abdelah Ahnaou"'
Autor:
Pype Stefan Maria Christiaan, Andrés A. Trabanco, Wilhelmus Drinkenburg, Abdelah Ahnaou, María Lourdes Linares, José Manuel Alonso, Guillaume Albert Jacques Duvey, Ana Isabel de Lucas, Sonia Poli, Jean-Philippe Rocher, Terry Patrick Finn, Juan Antonio Vega, Claire Mackie, David J. Gallacher, Jesús Alcázar, Encarnación Matesanz, José Ignacio Andrés, Daniel Oehlrich, Hilde Lavreysen, Robert Johannes Lütjens, Gregor James Macdonald, José María Cid, Gary Tresadern
Publikováno v:
Journal of Medicinal Chemistry. 57:6495-6512
We previously reported the discovery of 4-aryl-substituted pyridones with mGlu2 PAM activity starting from the HTS hit 5. In this article, we describe a different exploration from 5 that led to the discovery of a novel subseries of phenylpiperidine-s
Autor:
Gary Tresadern, Juan Antonio Vega, Andrés A. Trabanco, Encarnación Matesanz, María Lourdes Linares, José Ignacio Andrés, Claire Mackie, Gregor James Macdonald, Daniel Oehlrich, Ana Isabel de Lucas, Abdelah Ahnaou, Aránzazu García, Hilde Lavreysen, Wilhelmus Drinkenburg, José Manuel Alonso, José María Cid, Sergio A. Alonso de Diego
Publikováno v:
Journal of Medicinal Chemistry. 55:2688-2701
Advanced leads of an imidazopyridine series of positive allosteric modulators of the metabotropic glutamate 2 (mGlu2) receptor are reported. The optimization of in vitro ADMET and in vivo pharmacokinetic properties led to the identification of 27o. W