Design, synthesis, chemical characterization, biological evaluation, and docking study of new 1,3,4-oxadiazole homonucleoside analogs

Autor: Mohamed Zahouily, Graciela Andrei, Hassan Ait Benhassou, Abdeladim Moumen, Mohamed Maatallah, Hassan B. Lazrek, Robert Snoeck, Az-Eddine El Mansouri, Ahmad Mehdi

Publikováno v: Nucleosides, Nucleotides and Nucleic Acids
Nucleosides, Nucleotides and Nucleic Acids, Taylor & Francis, 2020, 39 (8), pp.1088-1107. ⟨10.1080/15257770.2020.1761982⟩
Nucleosides, Nucleotides and Nucleic Acids, Taylor & Francis, 2020, pp.1-20. ⟨10.1080/15257770.2020.1761982⟩

Herein, we report the synthetic strategies and characterization of some novel 1,3,4-oxadiazole homonucleoside analogs that are relevant to potential antitumor and cytotoxic activities. The structure of all compounds is confirmed using various spectro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6efac3974b4c452f47338c82e4ba461
https://hal.archives-ouvertes.fr/hal-02914848

Evaluation of Combined Quantification of PCA3 and AMACR Gene Expression for Molecular Diagnosis of Prostate Cancer in Moroccan Patients by RT-qPCR

Autor: Imane, Abdellaoui Maane, Hicham, El Hadi, Zineb, Qmichou, Abderrahmane, Al Bouzidi, Youssef, Bakri, Hassan, Sefrioui, Nadia, Dakka, Abdeladim, Moumen

Publikováno v: Asian Pacific Journal of Cancer Prevention : APJCP

Prostate cancer (PCa) remains one of the most widespread and perplexing of all human malignancies. Assessment of gene expression is thought to have an important impact on cancer diagnosis, prognosis and therapeutic decisions. In this context, we expl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4a2fb39fb58b48af61f59cc6265f3eab
https://pubmed.ncbi.nlm.nih.gov/28125866

Role of ubiquitination in the DNA damage response: proteomic analysis to identify new DNA-damage-induced ubiquitinated proteins

Autor: Jogitha Selvarajah, Abdeladim Moumen

Publikováno v: Biochemical Society Transactions. 38:87-91

The DDR (DNA damage response) is a signalling transduction cascade utilizing many forms of post-translation modification of proteins, including phosphorylation and ubiquitination. The well-known function of ubiquitination is to target proteins for pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a84567f187dd898748bbb3c17eac6947
https://doi.org/10.1042/bst0380087

Evaluation of a novel multiplex RT-qPCR assay for the quantification of leukemia-associated BCR-ABL1 translocation

Autor: Hind Dehbi, M. El Amrani, Dolors Colomer, Sellama Nadifi, D. Kottwitz, Asma Quessar, Abdeladim Moumen, H. El Hadi, Sandra Cabezas, EL Hassan Sefrioui

Publikováno v: International journal of hematology. 102(3)

Although monitoring of BCR-ABL1 translocation has become an established practice in the management of chronic myeloid leukemia (CML), the detection limit of the BCR-ABL1 transcripts needs more standardization. The aim of the present study was to eval

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575c8aefb60f130c93b9138d858fcfaf
https://pubmed.ncbi.nlm.nih.gov/26243622

The Structure of HIV-1 Genomic RNA in the gp120 Gene Determines a Recombination Hot Spot in Vivo

Autor: Michel Veron, Roman Galetto, Pierre Charneau, Matteo Negroni, Véronique Giacomoni, Abdeladim Moumen

Publikováno v: Journal of Biological Chemistry. 279:36625-36632

By frequently rearranging large regions of the genome, genetic recombination is a major determinant in the plasticity of the human immunodeficiency virus type I (HIV-1) population. In retroviruses, recombination mostly occurs by template switching du

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c499870d55f3c5a5d195d7e123da52a
https://doi.org/10.1074/jbc.m405476200