Synthesis and Antimicrobial Evaluation of New 1,2,4-Triazolo[1,5- a ]pyrimidine-Based Derivatives as Dual Inhibitors of Bacterial DNA Gyrase and DHFR.

Autor: Al-Wahaibi LH; Department of Chemistry, College of Sciences, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia., Rabea SM; Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt., Mahmoud MA; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt., Youssif BGM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt., Bräse S; Institute of Biological and Chemical Systems, IBCS-FMS, Karlsruhe Institute of Technology, Karlsruhe 76131, Germany., Abdel-Aziz SA; Department of Pharmaceutical Medicinal Chemistry and Drug Design, Faculty of Pharmacy (Boys), Al-Azhar University, Assiut 71524, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, Minia 61519, Egypt.

Publikováno v: ACS omega [ACS Omega] 2024 Nov 11; Vol. 9 (47), pp. 47261-47273. Date of Electronic Publication: 2024 Nov 11 (Print Publication: 2024).

In Vitro and Randomized Controlled Clinical Study of Natural Constituents' Anti-HPV Potential for Treatment of Plantar Warts Supported with In Silico Studies and Network Analysis.

Autor: Shady NH; Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, Universities Zone, New Minia 61111, Egypt.; Center for Research and Sustainability, Deraya University, Universities Zone, New Minia 61111, Egypt., Mokhtar FA; Fujairah Research Centre, Sakamkam Road, Sakamkam, Fujairah 0000, United Arab Emirates.; Department of Pharmacognosy, Faculty of Pharmacy, El Saleheya El Gadida University, El Saleheya El Gadida, Sharkia 44813, Egypt., Abdullah HS; Faculty of Pharmacy, Deraya University, Universities Zone, New Minia City 61111, Egypt., Abdel-Aziz SA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, Universities Zone, New Minia 61111, Egypt.; Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt., Mohamad SA; Department of Clinical Pharmacy, Faculty of Pharmacy, Deraya University, Universities Zone, New Minia 61111, Egypt., Imam MS; Department of Clinical Pharmacy, College of Pharmacy, Shaqra University, Shaqra 11961, Saudi Arabia.; Department of Clinical Pharmacy, National Cancer Institute, Cairo University, Fom El Khalig Square, Kasr Al-Aini Street, Cairo 11796, Egypt., El Afify SR; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alsalam University, Kafr alzayat, Algharbia 31611, Egypt., Abdelmohsen UR; Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, Universities Zone, New Minia 61111, Egypt.; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.

Publikováno v: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2024 Jun 10; Vol. 17 (6). Date of Electronic Publication: 2024 Jun 10.

Antifungal and antibacterial investigation of quinary Zr Al Fe Co Ni layered double hydroxide and its Al Fe Co Ni quaternary and Fe Co Ni tertiary roots.

Autor: Mahmoud R; Chemistry Department, Faculty of Science, Beni-Suef University Beni-Suef 62511 Egypt radwaraft@yahoo.com rehabkhaled@science.bsu.edu.eg doaae4657@gmail.com., Eldin ZE; Department of Materials Science and Nanotechnology, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University Beni-Suef 62511 Egypt zienab_ryad@yahoo.com yasser191919@gmail.com., Khalifa A; Biological Science Department, College of Science, King Faisal University P. O. Box 400 Al-Ahsa 31982 Saudi Arabia.; Botany and Microbiology Department, Faculty of Science, Beni-Suef University Beni-Suef 62511 Egypt akhalifa@kfu.edu.sa., Ahmed Anwar AA; Chemistry Department, Faculty of Science, Beni-Suef University Beni-Suef 62511 Egypt radwaraft@yahoo.com rehabkhaled@science.bsu.edu.eg doaae4657@gmail.com., GadelHak Y; Department of Materials Science and Nanotechnology, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University Beni-Suef 62511 Egypt zienab_ryad@yahoo.com yasser191919@gmail.com., Othman SI; Department of Biology, College of Science, Princess Nourah Bint Abdulrahman University P. O. Box 84428 Riyadh 11671 Saudi Arabia sialothman@pnu.edu.sa., Allam AA; Department of Zoology, Faculty of Science, Beni-suef University Beni-suef 65211 Egypt Ahmed.aliahmed@science.bsu.edu.eg., Essam D; Chemistry Department, Faculty of Science, Beni-Suef University Beni-Suef 62511 Egypt radwaraft@yahoo.com rehabkhaled@science.bsu.edu.eg doaae4657@gmail.com., Abo El-Ela FI; Department of Pharmacology, Faculty of Veterinary Medicine, Beni-Suef University 62511 Egypt Fatma.aboel3la@vet.bsu.edu.eg fa.pharma@yahoo.com., Aleem Abdel Aziz SA; Department of Hygiene, Zoonoses and Epidemiology, Faculty of Veterinary Medicine, Beni-Suef University Beni-Suef 62511 Egypt abdelaziz.sahar@yahoo.com., Zaher A; Environmental Science and Industrial Development Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University Beni-Suef 62511 Egypt amal_2006z@yahoo.com.

Publikováno v: RSC advances [RSC Adv] 2024 May 07; Vol. 14 (21), pp. 14815-14834. Date of Electronic Publication: 2024 May 07 (Print Publication: 2024).

Development and Assessment of 1,5-Diarylpyrazole/Oxime Hybrids Targeting EGFR and JNK-2 as Antiproliferative Agents: A Comprehensive Study through Synthesis, Molecular Docking, and Evaluation.

Autor: Abdelrahman KS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt., Hassan HA; Department of Medicinal Chemistry Faculty of Pharmacy, Minia University, Minia 61519, Egypt., Abdel-Aziz SA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, Minia 61768, Egypt., Marzouk AA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.; National Center for Natural Products Research, School of Pharmacy, University of Missippi, Oxford, MS 38677, USA., Shams R; Emergent Bioengineering Materials Research Team, RIKEN Centre for Emergent Matter Science, RIKEN, Wako 351-0198, Saitama, Japan., Osawa K; Graduate School of Science and Engineering, Yamagata University, Yonezawa 992-8510, Yamagata, Japan., Abdel-Aziz M; Department of Medicinal Chemistry Faculty of Pharmacy, Minia University, Minia 61519, Egypt., Konno H; Graduate School of Science and Engineering, Yamagata University, Yonezawa 992-8510, Yamagata, Japan.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2023 Sep 08; Vol. 28 (18). Date of Electronic Publication: 2023 Sep 08.

New pyrimidine/thiazole hybrids endowed with analgesic, anti-inflammatory, and lower cardiotoxic activities: Design, synthesis, and COX-2/sEH dual inhibition.

Autor: Abdel-Aziz SA; Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, Minia, Egypt., Taher ES; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt., Lan P; Institute for Advanced and Applied Chemical Synthesis, Jinan University, Guangzhou, China., El-Koussi NA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, Minia, Egypt.; Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt., Salem OIA; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt., Gomaa HAM; Pharmacology Department, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia., Youssif BGM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt.

Publikováno v: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2022 Jul; Vol. 355 (7), pp. e2200024. Date of Electronic Publication: 2022 Apr 15.