Zobrazeno 1 - 10 of 72 pro vyhledávání: '"Abdel Rahim A Hamad"'
1
Akademický článek
Fas-mediated apoptosis regulates the composition of peripheral alphabeta T cell repertoire by constitutively purging out double negative T cells.
Autor: Abdiaziz S Mohamood, Dylan Bargatze, Zuoxiang Xiao, Chunfa Jie, Hideo Yagita, Dawn Ruben, Julie Watson, Shukti Chakravarti, Jonathan P Schneck, Abdel Rahim A Hamad
Publikováno v: PLoS ONE, Vol 3, Iss 10, p e3465 (2008)
The Fas pathway is a major regulator of T cell homeostasis, however, the T cell population that is controlled by the Fas pathway in vivo is poorly defined. Although CD4 and CD8 single positive (SP) T cells are the two major T cell subsets in the peri
Externí odkaz: https://doaj.org/article/4c6c04b2755c4da9b98dcaf3906df5ae
Zobrazit plný text záznamu
2
Apposed networks of interacting TCRs and BCRs exhibiting mosaicked CDR3 sequences made of fixed junctional motifs
Autor: Rizwan Ahmed, Neha Majety, Kevin C. Chan, Adebola Giwa, Joseph Heinemann, Hao Zhang, Joseph Margolick, Rafid Al-Hallaf, Prajita Paul, David R. Bell, Yi Song, Sangyun Lee, Ruhong Zhou, Risa M Wolfe, Thomas Donner, Chunfa Jie, Abdel Rahim A Hamad
T and B cells are the two arms of the adaptive immune system that mediate cellular and humoral immunity, respectively, using highly diverse repertoires of antigen receptors. T cells recognize antigens using the T cell receptor (TCR), whereas B cells
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99923d1ff7e26a1e18e07ea7b86ad4a3
https://doi.org/10.1101/2023.05.06.539704
Zobrazit plný text záznamu
3
A mutagenesis study of autoantigen optimization for potential T1D vaccine design
Autor: Yi Song, David R. Bell, Rizwan Ahmed, Kevin C. Chan, Sangyun Lee, Abdel Rahim A. Hamad, Ruhong Zhou
Publikováno v: Proceedings of the National Academy of Sciences. 120
A previously reported autoreactive antigen, termed the X-idiotype, isolated from a unique cell population in Type 1 diabetes (T1D) patients, was found to stimulate their CD4+ T cells. This antigen was previously determined to bind more favorably than
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6fdef06ef85bc9aa1053bf4889a805fc
https://doi.org/10.1073/pnas.2214430120
Zobrazit plný text záznamu
6
A reply to 'TCR+/BCR+ dual-expressing cells and their associated public BCR clonotype are not enriched in type 1 diabetes'
Autor: Zahra Omidian, Thomas Donner, Abdel Rahim A. Hamad, Adebola Giwa, Chunfa Jie, Rizwan Ahmed
Publikováno v: Cell
We have recently identified a novel lymphocyte that is a dual expresser (DE) of TCRαβ and BCR. DEs in T1D patients are predominated by a public BCR clonotype (clone-x) that encodes a potent autoantigen that cross-activates insulin-reactive T cells.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7322c54c1fc2d63e113273e35b4d8a66
https://doi.org/10.1016/j.cell.2020.11.036
Zobrazit plný text záznamu
7
TCR+CD4−CD8− (double negative) T cells protect from cisplatin-induced renal epithelial cell apoptosis and acute kidney injury
Autor: Hamid Rabb, Johanna T. Kurzhagen, Sanjeev Noel, Jing Gong, Sul A Lee, Errol L. Bush, Lois J. Arend, Abdel Rahim A. Hamad, Mohanraj Sadasivam, Joshua Hsu
Publikováno v: American Journal of Physiology-Renal Physiology. 318:F1500-F1512
Acute kidney injury (AKI) due to cisplatin is a significant problem that limits its use as an effective chemotherapeutic agent. T cell receptor+CD4−CD8− double negative (DN) T cells constitute the major T cell population in the human and mouse ki
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::905ca47593bab1f87dcced9a492d7812
https://doi.org/10.1152/ajprenal.00033.2020
Zobrazit plný text záznamu
8
Lack of Syndecan-1 produces significant alterations in whole-body composition, metabolism and glucose homeostasis in mice
Autor: Anil Kumar Jaiswal, Abdel Rahim A. Hamad, Susan Aja, Mohanraj Sadasivam
Publikováno v: World Journal of Diabetes
BACKGROUND Obesity is a disease state with serious adverse metabolic complications, including glucose intolerance and type 2 diabetes that currently has no cure. Identifying and understanding roles of various modulators of body composition and glucos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5918933b66a01bee4334795b3b89e471
https://doi.org/10.4239/wjd.v11.i4.126
Zobrazit plný text záznamu
9
Current understandings of the pathogenesis of type 1 diabetes: Genetics to environment
Autor: Zahra Omidian, Thomas Donner, Sarah M Omer, Neha Majety, Abdel Rahim A. Hamad, Adebola Giwa, Kagan Ege Karakus, Rizwan Ahmed
Publikováno v: World Journal of Diabetes
Type 1 diabetes (T1D) is an autoimmune disease that usually strikes early in life, but can affect individuals at almost any age. It is caused by autoreactive T cells that destroy insulin-producing beta cells in the pancreas. Epidemiological studies e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baae65a14aec9f9cbcf225fc4e4a63e2
http://europepmc.org/articles/PMC6927819
Zobrazit plný text záznamu
10
Detection, sorting, and immortalization of dual expresser lymphocytes from human peripheral blood samples
Autor: Hao Zhang, Kusuma Ananth, Zahra Omidian, Rizwan Ahmed, Neha Majety, Abdel Rahim A. Hamad
Publikováno v: STAR Protocols
STAR Protocols, Vol 2, Iss 4, Pp 100925-(2021)
Summary This protocol describes how to identify Dual Expressers (DEs), a rare type of lymphocyte that co-expresses B-cell receptors and T-cell receptors, by flow cytometry using a cocktail of four antibodies. It also shows the subsequent gating strat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430a7dab6d6cc88924492d082353f9d9
http://europepmc.org/articles/PMC8564191
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje