Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Abdel A. Alli"'
Autor:
Whitney C. Schramm, Niharika Bala, Tanmay Arekar, Zeeshan Malik, Kevin M. Chacko, Russell L. Lewis, Nancy D. Denslow, Yogesh Scindia, Abdel A. Alli
Publikováno v:
Biomedicines, Vol 12, Iss 5, p 1038 (2024)
Cathepsin B (CtsB) is a ubiquitously expressed cysteine protease that plays important roles in health and disease. Urinary extracellular vesicles (uEVs) are released from cells associated with urinary organs. The antibiotic streptozotocin (STZ) is kn
Externí odkaz:
https://doaj.org/article/9b9464a245774e568d994ebb4daab8a3
Autor:
Abdel A. Alli
Publikováno v:
Biology, Vol 12, Iss 8, p 1138 (2023)
Extracellular vesicles (EVs) include exosomes, microvesicles, and apoptotic bodies. EVs are released by all cell types and are found in biological fluids including plasma and urine. Urinary extracellular vesicles (uEVs) are a mixed population of EVs
Externí odkaz:
https://doaj.org/article/16dde938ccf24378a1b64687d21a703b
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12484 (2023)
The expression of the myristoylated alanine-rich C-kinase substrate (MARCKS) family of proteins in the kidneys plays an important role in the regulation of the renal epithelial sodium channel (ENaC) and hence overall blood pressure regulation. The fu
Externí odkaz:
https://doaj.org/article/c7ca6eacb50045d7a22c0a856d0b5dde
Autor:
Raphaelle D. Vallera, Yanli Ding, Kimmo J. Hatanpaa, Justin A. Bishop, Sasan Mirfakhraee, Abdel A. Alli, Sergei G. Tevosian, Mouna Tabebi, Oliver Gimm, Peter Söderkvist, Cynthia Estrada-Zuniga, Patricia L. M. Dahia, Hans K. Ghayee
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Genetic testing has become the standard of care for many disease states. As a result, physicians treating patients who have tumors often rely on germline genetic testing results for making clinical decisions. Cases of two sisters carrying a germline
Externí odkaz:
https://doaj.org/article/0dd7056bb2134495ad2e44dcbc99498e
Autor:
Tamim Kawakibi, Niharika Bala, Lauren P. Liu, Louis A. Searcy, Nancy D. Denslow, Abdel A. Alli
Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1489 (2023)
Cathpesin B is a multi-functional protease that plays numerous roles in physiology and pathophysiology. We hypothesized that actin cytoskeleton proteins that are substrates of cathepsin B, various lipids, and kinases that are regulated by lipids woul
Externí odkaz:
https://doaj.org/article/dbd96dc1e0234321a07b9a0d67f7c580
Autor:
Yogesh M. Scindia, Mohammed F. Gholam, Alina Waleed, Lauren P. Liu, Kevin M. Chacko, Dhruv Desai, Juliana Pena Lopez, Zeeshan Malik, Whitney C. Schramm, Angelica G. Morales, Morgan Carson-Marino, Abdel A. Alli
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 305 (2023)
Diabetic nephropathy is the primary cause of morbidity in type 2 diabetes mellitus (T2DM) patients. New data indicate that hypertension, a common comorbidity in T2DM, can worsen outcomes of diabetic nephropathy. While metformin is a commonly prescrib
Externí odkaz:
https://doaj.org/article/7fcb29cb8c8f465bab7cddaaa2531bef
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1408 (2023)
In addition to inhibiting renal glucose reabsorption and allowing for glucose excretion, the sodium/glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin may be efficacious in treating various comorbidities associated with type 2 diabetes mellitus
Externí odkaz:
https://doaj.org/article/a2ccd9946a0c495b87bf67385e93a810
Autor:
Sara Darwish, Lauren P. Liu, Tanya O. Robinson, Spurthi Tarugu, Anna H. Owings, Sarah C. Glover, Abdel A. Alli
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1654 (2023)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is the causative agent of the COVID-19 disease. COVID-19 viral infection can affect many cell types, including epithelial cells of the lungs and airways. Extracellular vesicles (EVs)
Externí odkaz:
https://doaj.org/article/5330185302864705a91a1bbee244f13e
Autor:
Carlos I. Lugo, Lauren P. Liu, Niharika Bala, Angelica G. Morales, Mohammed F. Gholam, Julia C. Abchee, Nasseem Elmoujahid, Ahmed Samir Elshikha, Rigena Avdiaj, Louis A. Searcy, Nancy D. Denslow, Sihong Song, Abdel A. Alli
Publikováno v:
Biomolecules, Vol 13, Iss 1, p 66 (2022)
Hypertension may develop before or after the onset of diabetes and it is known to increase the risk of developing diabetic nephropathy. Alpha-1 antitrypsin (AAT) is a multi-functional protein with beneficial effects in various diseases but its role i
Externí odkaz:
https://doaj.org/article/e33cb0622d164d038d065d98b67dae99
Autor:
Juliana Pena Lopez, Mohammad-Zaman Nouri, Areej Ebrahim, Kevin M. Chacko, Whitney C. Schramm, Mohammed F. Gholam, Tezcan Ozrazgat-Baslanti, Nancy D. Denslow, Abdel A. Alli
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 15397 (2022)
Hypertension remains a major problem, especially in the elderly, as it increases the risk for cardiovascular, coronary artery, cerebrovascular, and kidney diseases. Extracellular vesicles (EVs) play a role in the aging process and contribute to patho
Externí odkaz:
https://doaj.org/article/e15dea162a014a5badaae11842512275