Funktionalisierung von Chlorotonilen: Dehalogenil als vielversprechende Leitverbindung für die in vivo‐Anwendung.

Autor: Hofer, Walter, Deschner, Felix, Jézéquel, Gwenaëlle, Pessanha de Carvalho, Laìs, Abdel‐Wadood, Noran, Pätzold, Linda, Bernecker, Steffen, Morgenstern, Bernd, Kany, Andreas M., Große, Miriam, Stadler, Marc, Bischoff, Markus, Hirsch, Anna K. H., Held, Jana, Herrmann, Jennifer, Müller, Rolf

Publikováno v: Angewandte Chemie; May2024, Vol. 136 Issue 19, p1-11, 11p

Bitter taste signaling in tracheal epithelial brush cells elicits innate immune responses to bacterial infection.

Autor: Hollenhorst MI; Institute of Anatomy and Cell Biology, Saarland University, School of Medicine, Homburg, Germany., Nandigama R; Institute of Anatomy and Cell Biology, Julius-Maximilians-University, Würzburg, Germany., Evers SB; Institute of Anatomy and Cell Biology, Saarland University, School of Medicine, Homburg, Germany., Gamayun I; Institute for Experimental and Clinical Pharmacology and Toxicology, Saarland University, School of Medicine, Homburg, Germany., Abdel Wadood N; Institute of Anatomy and Cell Biology, Saarland University, School of Medicine, Homburg, Germany., Salah A; Institute of Anatomy and Cell Biology, Saarland University, School of Medicine, Homburg, Germany., Pieper M; Institute of Anatomy, University of Lübeck, and Airway Research Center North (ARCN), Lübeck, Germany.; German Center for Lung Research (DZL), Germany., Wyatt A; Institute for Experimental and Clinical Pharmacology and Toxicology, Saarland University, School of Medicine, Homburg, Germany., Stukalov A; Immunopathology of Virus Infections Laboratory, Institute of Virology, School of Medicine, Technical University of Munich, Munich, Germany., Gebhardt A; Immunopathology of Virus Infections Laboratory, Institute of Virology, School of Medicine, Technical University of Munich, Munich, Germany., Nadolni W; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig-Maximilians-University, Munich, Germany., Burow W; Institute of Anatomy and Cell Biology, Julius-Maximilians-University, Würzburg, Germany., Herr C; Department of Internal Medicine V-Pulmonology, Allergology, Intensive Care Medicine, Saarland University Hospital, Homburg, Germany., Beisswenger C; Department of Internal Medicine V-Pulmonology, Allergology, Intensive Care Medicine, Saarland University Hospital, Homburg, Germany., Kusumakshi S; Institute for Experimental and Clinical Pharmacology and Toxicology, Saarland University, School of Medicine, Homburg, Germany., Ectors F; FARAH Mammalian Transgenics Platform, Liège University, Liège, Belgium., Kichko TI; Institute of Physiology and Pathophysiology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany., Hübner L; Institute of Anatomy and Cell Biology, Julius-Maximilians-University, Würzburg, Germany., Reeh P; Institute of Physiology and Pathophysiology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany., Munder A; German Center for Lung Research (DZL), Germany.; Clinic for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, and Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Hannover, Germany., Wienhold SM; Department of Infectious Diseases and Respiratory Medicine and Division of Pulmonary Inflammation, Charité - University Medicine Berlin, corporate member of Free University Berlin and Humboldt-University Berlin, Berlin, Germany., Witzenrath M; Department of Infectious Diseases and Respiratory Medicine and Division of Pulmonary Inflammation, Charité - University Medicine Berlin, corporate member of Free University Berlin and Humboldt-University Berlin, Berlin, Germany., Bals R; Department of Internal Medicine V-Pulmonology, Allergology, Intensive Care Medicine, Saarland University Hospital, Homburg, Germany., Flockerzi V; Institute for Experimental and Clinical Pharmacology and Toxicology, Saarland University, School of Medicine, Homburg, Germany.; Center for Molecular Signaling., Gudermann T; German Center for Lung Research (DZL), Germany.; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig-Maximilians-University, Munich, Germany., Bischoff M; Institute for Medical Microbiology and Hygiene, and., Lipp P; Department of Infectious Diseases and Respiratory Medicine and Division of Pulmonary Inflammation, Charité - University Medicine Berlin, corporate member of Free University Berlin and Humboldt-University Berlin, Berlin, Germany.; Institute for Molecular Cell Biology and Research Center for Molecular Imaging and Screening, Saarland University, Homburg, Germany., Zierler S; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig-Maximilians-University, Munich, Germany.; Institute of Pharmacology, Johannes Kepler University Linz, Linz, Austria., Chubanov V; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig-Maximilians-University, Munich, Germany., Pichlmair A; Immunopathology of Virus Infections Laboratory, Institute of Virology, School of Medicine, Technical University of Munich, German Center for Infection Research (DZIF), Munich, Germany., König P; Institute of Anatomy, University of Lübeck, and Airway Research Center North (ARCN), Lübeck, Germany.; German Center for Lung Research (DZL), Germany., Boehm U; Institute for Experimental and Clinical Pharmacology and Toxicology, Saarland University, School of Medicine, Homburg, Germany.; Center for Molecular Signaling., Krasteva-Christ G; Institute of Anatomy and Cell Biology, Saarland University, School of Medicine, Homburg, Germany.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2022 Jul 01; Vol. 132 (13).