Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Abde M. Abukhdeir"'
Autor:
Molly DiScala, Matthew S Najor, Timothy Yung, Deri Morgan, Abde M Abukhdeir, Melody A Cobleigh
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234146 (2020)
Approximately 20% of breast cancers are HER2-positive. Trastuzumab has improved patient outcomes significantly for these cancers. However, acquired resistance remains a major hurdle in the clinical management of these patients. Therefore, identifying
Externí odkaz:
https://doaj.org/article/53bcf4b5a1294ff8a62f60026c5f7c46
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0227522 (2020)
Expression of the voltage gated proton channel (Hv1) as identified by immunocytochemistry has been reported previously in breast cancer tissue. Increased expression of HV1 was correlated with poor prognosis and decreased overall and disease-free surv
Externí odkaz:
https://doaj.org/article/e536587372434cc28cdc26fc8a02464d
Autor:
Ben Ho Park, Kurtis E. Bachman, Eike Gallmeier, Yuko Konishi, Joseph P. Garay, John P. Gustin, Josh Lauring, Abde M. Abukhdeir, Bedri Karakas, Hiroyuki Konishi
Supplementary Figure Legends 1-4 from Knock-in of Mutant K-ras in Nontumorigenic Human Epithelial Cells as a New Model for Studying K-ras–Mediated Transformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::378b59285c9413cbc3fbbdcd3d809707
https://doi.org/10.1158/0008-5472.22367298.v1
https://doi.org/10.1158/0008-5472.22367298.v1
Autor:
Ben Ho Park, Josh Lauring, Pedram Argani, Yoshitaka Hosokawa, Akinobu Ota, Yuko Konishi, Sivasundaram Karnan, Rory L. Cochran, Sarah Croessmann, Danijela Jelovac, Justin Cidado, Michaela J. Higgins, Morassa Mohseni, Joseph P. Garay, William Matsui, Zeshaan Rasheed, Samuel Ray Denmeade, D. Marc Rosen, John P. Gustin, Abde M. Abukhdeir, Brian G. Blair, Hiroyuki Konishi, Hong Yuen Wong, Grace M. Wang
PDF file - 1480K, Figure S1. Double knock in clones have single mutant PIK3CA alleles and equivalent expression of mutant and wild type PIK3CA and form aberrant structures in 3D culture. Figure S2. DKI xenografts retain the same number of KRAS and PI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cbb464b436aa1e0e0399e735863603e
https://doi.org/10.1158/0008-5472.22397007
https://doi.org/10.1158/0008-5472.22397007
Autor:
Ben Ho Park, Kurtis E. Bachman, Eike Gallmeier, Yuko Konishi, Joseph P. Garay, John P. Gustin, Josh Lauring, Abde M. Abukhdeir, Bedri Karakas, Hiroyuki Konishi
Supplementary Table 1, Figures 1-4 from Knock-in of Mutant K-ras in Nontumorigenic Human Epithelial Cells as a New Model for Studying K-ras–Mediated Transformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd267aacb2f56a355c86ef8c0d77fd7
https://doi.org/10.1158/0008-5472.22367295.v1
https://doi.org/10.1158/0008-5472.22367295.v1
Autor:
Ben Ho Park, Kurtis E. Bachman, Eike Gallmeier, Yuko Konishi, Joseph P. Garay, John P. Gustin, Josh Lauring, Abde M. Abukhdeir, Bedri Karakas, Hiroyuki Konishi
The oncogenic function of mutant ras in mammalian cells has been extensively investigated using multiple human and animal models. These systems include overexpression of exogenous mutant ras transgenes, conditionally expressed knock-in mouse models,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a0660684f5aab2324d406106c5e665
https://doi.org/10.1158/0008-5472.c.6495501.v1
https://doi.org/10.1158/0008-5472.c.6495501.v1
Autor:
Abde M. Abukhdeir, Melody Cobleigh
Publikováno v:
Cancer Research. 83:2248-2248
Background: The PIK3R1 gene is genetically altered in up to ~5% of triple negative breast cancers (TNBCs). We previously reported that breast cancer cells lacking protein expression of PIK3R1 had elevated levels of activated MEK, sensitizing them to
Autor:
Liam Portt, Melody A. Cobleigh, Sanja Turturro, Matthew S. Najor, Satnam Brar, Abde M. Abukhdeir, Timothy Yung
Publikováno v:
Cancer Research. 81:PS18-30
Background: The Ras signaling pathway is a key oncogenic growth signaling pathway. The neurofibromatosis gene (NF1) is a tumor suppressor gene and negative regulator of Ras. Approximately 20% of breast cancers experience loss of active NF1 protein, l
Autor:
Soma Ghosh, Willie Wilson, Pengfei Song, Laleh Amiri-Kordestani, Sherry Hou, Junshan Qiu, Hui Zhang, Richard Pazdur, Jeffrey D. Seidman, Julia A. Beaver, Reena Philip, Fatima Rizvi, Jennifer J Gao, Abde M. Abukhdeir, Vishal Bhatnagar, Yutao Gong, Haw-Jyh Chiu, Tiffany K. Ricks, Nam Atiqur Rahman, Paul G. Kluetz, William F. Pierce, Erik Bloomquist, Christy L. Osgood, Xiling Jiang, Jingyu Yu
Publikováno v:
Clinical Cancer Research. 27:2126-2129
On June 29, 2020, the FDA approved pertuzumab, trastuzumab, and hyaluronidase-zzxf subcutaneous injection (Phesgo) for the treatment of patients with HER2-positive early-stage and metastatic breast cancer. Patients should be selected for therapy base
Autor:
Trevor Rempert, Abde M. Abukhdeir, Melody A. Cobleigh, Andrew Armstrong, Faraz Bishehsari, Mathew Najor
Publikováno v:
International Journal of Sciences. 9:7-17
HER2 amplification results in increased tumor growth and aggressiveness in breast cancer. Despite advancements in HER2-targeted therapy, treatment resistance, cancer recurrence, and metastasis remain significant obstacles in combating this deadly dis