The NLRP6 protein is very faintly expressed in several normal and cancerous epithelial cells and may be confused with an unrelated protein.

Autor: Abdallah Mound, Gautier Goormachtigh, Fabrice Bray, Stéphanie Flament, Christian Rolando, Richard Ruez, Nathalie Martin, Amélie Decourcelle, Vanessa Dehennaut, Jean-Michel Saliou, Mathias Chamaillard, Corinne Abbadie

Publikováno v: PLoS ONE, Vol 18, Iss 1, p e0279028 (2023)

Nod-Like Receptor Pyrin domain-containing protein 6 (NLRP6), a member of the Nucleotide-oligomerization domain-Like Receptor (NLR) family of proteins, assembles together with the ASC protein to form an inflammasome upon stimulation by bacterial lipot

Externí odkaz: https://doaj.org/article/c2c50a21ed4242d0983f0d569b18cc7d

Modelling atopic dermatitis during the morphogenetic process involved in reconstruction of a human epidermis

Autor: Yves Poumay, C. Lambert de Rouvroit, E. De Vuyst, Abdallah Mound

Publikováno v: Current Research in Translational Medicine. 64:179-183

Most crucial role of epidermis is to maintain efficient barrier between the organism and its environment. This barrier is however perturbed in inflammatory skin conditions like atopic dermatitis (AD), one common chronic disease. This review depicts c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::385a91143bc8c34b577fb45a348f7d26
https://doi.org/10.1016/j.retram.2016.10.005

Non-senescent keratinocytes organize in plasma membrane submicrometric lipid domains enriched in sphingomyelin and involved in re-epithelialization

Autor: Vesela Lozanova, Florence Debacq-Chainiaux, Catherine Lambert de Rouvroit, Maryse Hermant, Abdallah Mound, Christelle Guéré, Julie Robic, Céline Warnon, Yves Poumay, Donatienne Tyteca, Katell Vié

Publikováno v: Mound, A, Lozanova, V, Warnon, C, Hermant, M, Robic, J, Guere, C, Vie, K, Lambert de Rouvroit, C, Tyteca, D, Debacq-Chainiaux, F & Poumay, Y 2017, ' Non-senescent keratinocytes organize in plasma membrane submicrometric lipid domains enriched in sphingomyelin and involved in re-epithelialization ', Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, vol. 1862, no. 9, pp. 958-971 . https://doi.org/10.1016/j.bbalip.2017.06.001

Membrane lipid raft model has long been debated, but recently the concept of lipid submicrometric domains has emerged to characterize larger (micrometric) and more stable lipid membrane domains. Such domains organize signaling platforms involved in n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e5abd8ad4f492f89d68f8685d9668a
https://pure.unamur.be/ws/files/53094353/1_s2.0_S138819811730104X_main.pdf

Epidermal reference genes at the forefront of data interpretation

Autor: Mark R. Pittelkow, Aurélie Hayez, Abdallah Mound, Catherine Lambert de Rouvroit, Evelyne De Vuyst, Yves Poumay, Jérémy Malaisse

Publikováno v: Experimental dermatology. 24(10)

The characterization of gene expression, its identification and its measurement, is essential for understanding the somewhat unique fate of keratinocytes, their normal functions, but also the behavior of this cell type in skin diseases. Normal kerati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7802b7ff05daf91c250f7004aba6ae45
https://pubmed.ncbi.nlm.nih.gov/25980460

103 Sphingomyelin concentrates into lipid microdomains only in non-senescent cells and enhances keratinocyte migration

Autor: Christelle Guéré, Abdallah Mound, Donatienne Tyteca, Katell Vié, Florence Debacq-Chainiaux, C. Lambert de Rouvroit, Yves Poumay, V. Lozanova, Céline Warnon

Publikováno v: Journal of Investigative Dermatology. 136:S178

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b78b42e1ea3f0b4433a06c729579305
https://doi.org/10.1016/j.jid.2016.06.121