Rational design, synthesis and computational studies of multi-targeted anti-Alzheimer's agents integrating coumarin scaffold.

Autor: Abd El-Mageed MMA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562 Cairo, Egypt., Fattah Ezzat MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562 Cairo, Egypt. Electronic address: manal.salem@pharma.cu.edu.eg., Moussa SA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562 Cairo, Egypt., Abdel-Aziz HA; Department of Applied Organic Chemistry, National Research Center, Dokki, Giza, P.O. Box 12622, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Pharos University, Canal El Mahmoudia Street, 21648, Alexandria, Egypt., Elmasry GF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562 Cairo, Egypt.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2024 Dec 02; Vol. 154, pp. 108024. Date of Electronic Publication: 2024 Dec 02.

Design and synthesis of novel furan, furo[2,3-d]pyrimidine and furo[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives as potential VEGFR-2 inhibitors.

Autor: Abd El-Mageed MMA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr Alaini Street, 11562 Cairo, Egypt., Eissa AAM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr Alaini Street, 11562 Cairo, Egypt., Farag AE; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr Alaini Street, 11562 Cairo, Egypt., Osman EEA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr Alaini Street, 11562 Cairo, Egypt.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2021 Nov; Vol. 116, pp. 105336. Date of Electronic Publication: 2021 Sep 13.