Identification of new 5-(2,6-dichlorophenyl)-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-7-carboxylic acids as p38α MAPK inhibitors: Design, synthesis, antitumor evaluation, molecular docking and in silico studies.

Autor: El-Wakil MH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt. Electronic address: marwa.elwakil@alexu.edu.eg., El-Dershaby HA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt., Ghazallah RA; Department of Medical Biochemistry, Faculty of Medicine, Alexandria University, Alexandria 21521, Egypt., El-Yazbi AF; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt., Abd El-Razik HA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt., Soliman FSG; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2024 Apr; Vol. 145, pp. 107226. Date of Electronic Publication: 2024 Feb 18.

New pyrimidines and triazolopyrimidines as antiproliferative and antioxidants with cyclooxygenase-1/2 inhibitory potential.

Autor: Omar AM; Department of Medical Biotechnology, Genetic Engineering & Biotechnology Research Institute (GEBRI), City of Scientific Research & Technological Applications (SRTA-city), Borg El-Arab, Alexandria, Egypt., Abd El Razik HA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt., Hazzaa AA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt., El-Attar MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt., El Demellawy MA; Department of Medical Biotechnology, Genetic Engineering & Biotechnology Research Institute (GEBRI), City of Scientific Research & Technological Applications (SRTA-city), Borg El-Arab, Alexandria, Egypt., Abdel Wahab AE; Department of Medical Biotechnology, Genetic Engineering & Biotechnology Research Institute (GEBRI), City of Scientific Research & Technological Applications (SRTA-city), Borg El-Arab, Alexandria, Egypt., El Hawash SA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.

Publikováno v: Future medicinal chemistry [Future Med Chem] 2019 Jul; Vol. 11 (13), pp. 1583-1603.

Pyrazoles containing thiophene, thienopyrimidine and thienotriazolopyrimidine as COX-2 selective inhibitors: Design, synthesis, in vivo anti-inflammatory activity, docking and in silico chemo-informatic studies.

Autor: El-Shoukrofy MS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, 21521 Alexandria, Egypt. Electronic address: mai.elshoukrofy@alexu.edu.eg., Abd El Razik HA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, 21521 Alexandria, Egypt., AboulWafa OM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, 21521 Alexandria, Egypt., Bayad AE; Pharmacology Department, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt., El-Ashmawy IM; Pharmacology Department, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt; Department of Veterinary Medicine, Faculty of Agricultural and Veterinary Medicine, Qassim University, P.O. Box 1482, Buraydah, Al-Qassim, Saudi Arabia.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2019 Apr; Vol. 85, pp. 541-557. Date of Electronic Publication: 2019 Feb 18.

Structure-based development of novel triazoles and related thiazolotriazoles as anticancer agents and Cdc25A/B phosphatase inhibitors. Synthesis, in vitro biological evaluation, molecular docking and in silico ADME-T studies.

Autor: Rostom SAF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, P.O. Box 80260, Jeddah 21589, Saudi Arabia; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt. Electronic address: sherifrostom@yahoo.com., Badr MH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt., Abd El Razik HA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt., Ashour HMA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2017 Oct 20; Vol. 139, pp. 263-279. Date of Electronic Publication: 2017 Jul 25.

Synthesis of new pyrazolo[3,4-d]pyrimidine derivatives and evaluation of their anti-inflammatory and anticancer activities.

Autor: Abd El Razik HA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt., Mroueh M; Department of Pharmaceutical Sciences, School of Pharmacy, Lebanese American University, Byblos, Lebanon., Faour WH; School of Medicine, Lebanese American University, Byblos, Lebanon., Shebaby WN; Department of Natural Sciences, School of arts and sciences, Lebanese American University, Byblos, Lebanon., Daher CF; Department of Natural Sciences, School of arts and sciences, Lebanese American University, Byblos, Lebanon., Ashour HMA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt., Ragab HM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

Publikováno v: Chemical biology & drug design [Chem Biol Drug Des] 2017 Jul; Vol. 90 (1), pp. 83-96. Date of Electronic Publication: 2017 Feb 06.