The potential role of Tirzepatide as adjuvant therapy in countering colistin-induced nephro and neurotoxicity in rats via modulation of PI3K/p-Akt/GSK3-β/NF-kB p65 hub, shielding against oxidative and endoplasmic reticulum stress, and activation of p-CREB/BDNF/TrkB cascade

Autor: Hassan, Noha F., Ragab, Diaa, Ibrahim, Shaimaa G., Abd El-Galil, Mona M., Hassan Abd-El-Hamid, Asmaa, Hamed, Dalia M., Magdy William, Mira, Salem, Maha A.

Publikováno v: In International Immunopharmacology 30 June 2024 135

Cilostazol Counteracts Mitochondrial Dysfunction in Hepatic Encephalopathy Rat Model: Insights into the role of cAMP/AMPK/SIRT1/ PINK-1/Parkin hub and p-CREB /BDNF/ TrkB neuroprotective trajectory.

Autor: Gad ES; Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, AL Ahsa, Saudi Arabia; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Sinai University, Kantara Branch, Ismailia, Egypt., Aldossary SA; Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, AL Ahsa, Saudi Arabia., El-Ansary MR; Department of Biochemistry, Faculty of Pharmacy, Modern University for Technology and Information, Cairo, Egypt., Abd El-Galil MM; Department of Histology and Cell Biology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Abd-El-Hamid AH; Department of Histology and Cell Biology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., El-Ansary AR; Department of Internal Medicine, Faculty of Medicine, Misr University for Science and Technology, Cairo, Egypt., Hassan NF; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Modern University for Technology and Information, Cairo, Egypt. Electronic address: Noha.Fawzy@pharm.mti.edu.eg.

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2024 Dec 10, pp. 177194. Date of Electronic Publication: 2024 Dec 10.