Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice

Autor: Abd Alla, Joshua, Graemer, Muriel, Fu, Xuebin, Quitterer, Ursula

Publikováno v: In Journal of Biological Chemistry February 2016 291(6):2583-2600

The RAF Kinase Inhibitor Protein (RKIP): Good as Tumour Suppressor, Bad for the Heart

Autor: Abd Alla, Joshua, Quitterer, Ursula

Publikováno v: Cells, 11 (4)

The RAF kinase inhibitor protein, RKIP, is a dual inhibitor of the RAF1 kinase and the G protein-coupled receptor kinase 2, GRK2. By inhibition of the RAF1-MAPK (mitogen-activated protein kinase) pathway, RKIP acts as a beneficial tumour suppressor.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed7a22ed868c86b7c36d66b6d3ca778
https://hdl.handle.net/20.500.11850/533339

Stearoyl-CoA Desaturase (SCD) Induces Cardiac Dysfunction with Cardiac Lipid Overload and Angiotensin II AT1 Receptor Protein Up-Regulation

Autor: Abd Alla, Joshua, Jamous, Yahya F, Quitterer, Ursula

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 18
International Journal of Molecular Sciences, Vol 22, Iss 9883, p 9883 (2021)
International Journal of Molecular Sciences, 22 (18)

Heart failure is a major cause of death worldwide with insufficient treatment options. In the search for pathomechanisms, we found up-regulation of an enzyme, stearoyl-CoA desaturase 1 (Scd1), in different experimental models of heart failure induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad162b29a7d0eed17eb9b1f5b13f2b73

Sensitization of the Angiotensin II AT1 Receptor Contributes to RKIP-Induced Symptoms of Heart Failure

Autor: Wolf, Stefan, Abd Alla, Joshua, Quitterer, Ursula

Publikováno v: Frontiers in Medicine
Frontiers in Medicine, 5

Inhibition of the G-protein-coupled receptor kinase 2 (GRK2) is an emerging treatment approach for heart failure. Therefore, cardio-protective mechanisms induced by GRK2 inhibition are under investigation. We compared two different GRK2 inhibitors, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2ee80b44e8cd8aa3794e9d12f46b89
https://www.zora.uzh.ch/id/eprint/170358/

Target Identification and Characterization in Transgenic Cardiovascular Disease Models of Atherosclerosis and Heart Failure

Autor: Abd Alla, Joshua

Myocardial infarction and ensuing heart failure are leading causes of death worldwide with limited treatment options. The major aim of my thesis was to identify new pathways involved in the pathogenesis of these diseases, which could be exploited as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f21b44646278370f9eea7591db777f