Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Abd Al Roof Higazi"'
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Engulfed by the grave consequences of the coronavirus disease 2019 (COVID-19) pandemic, a better understanding of the unique pattern of viral invasion and virulence is of utmost importance. Angiotensin (Ang)-converting enzyme (ACE) 2 is a key compone
Externí odkaz:
https://doaj.org/article/5df172886bd344bb8095797d37f116b8
Autor:
Abd Al-Roof Higazi, Emad Maraga, Saja Baraghithy, Shiran Udi, Shahar Azar, Ann Saada, Benjamin Glaser, Dana Avrahami, Suhair Abdeen, Zenab Hamdan, Joseph Tam, Rami Abu Fanne
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108802- (2024)
Summary: Inflammation is consistently linked to dysmetabolism. In transgenic mice (Def+/+) model the neutrophilic peptide, alpha defensin, proved atherogenic. This phenotype occurred despite favorable cholesterol and glucose levels, and lower body we
Externí odkaz:
https://doaj.org/article/8c122a3bba874b13804e3fa36597452a
Publikováno v:
Medicina, Vol 59, Iss 5, p 983 (2023)
Background and Objectives: The neutrophilic peptide, alpha-defensin, is considered an evolving risk factor intimately linked with lipid mobilization. It was previously linked to augmented liver fibrosis. Here, we assess a potential association betwee
Externí odkaz:
https://doaj.org/article/d061968efaca4d9a8f224b2469f0e321
Autor:
Mohamed Higazi, Suhair Abdeen, Rami Abu-Fanne, Samuel N Heyman, Aseel Masarwy, Khalil Bdeir, Emad Maraga, Douglas B Cines, Abd Al-Roof Higazi
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231582 (2020)
Atherosclerosis, the predominant cause of death in well-resourced countries, may develop in the presence of plasma lipid levels within the normal range. Inflammation may contribute to lesion development in these individuals, but the underlying mechan
Externí odkaz:
https://doaj.org/article/7edbc5b3d3f044a396aa794b28049bca
Autor:
Mohamed Higazi, Douglas B. Cines, Suhair Abdeen, Abd Al-Roof Higazi, Rami Abu-Fanne, Emad Maraga, Khalil Bdeir, Samuel N. Heyman
Publikováno v:
British Journal of Haematology
Summary Patients who are severely affected by coronavirus disease 2019 (COVID‐19) may develop a delayed onset ‘cytokine storm’, which includes an increase in interleukin‐6 (IL‐6). This may be followed by a pro‐thrombotic state and increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82c5524bb3700b92bc6cbfecb10d53c
https://doi.org/10.1111/bjh.17885
https://doi.org/10.1111/bjh.17885
Autor:
Chandrasekaran Nagaswami, Khalil Bdeir, Alexander R. Mukhitov, Mohamed Higazi, Abd Al-Roof Higazi, Emad Maraga, John W. Weisel, Rustem I. Litvinov, Suhair Abdeen, Rami Abu-Fanne, Douglas B. Cines, Victoria Stepanova
Publikováno v:
Blood. 133:481-493
Inflammation and thrombosis are integrated, mutually reinforcing processes, but the interregulatory mechanisms are incompletely defined. Here, we examined the contribution of α-defensins (α-defs), antimicrobial proteins released from activated huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e6964ca10f7da42fc616c2e98346bf2
https://doi.org/10.1182/blood-2018-07-861237
https://doi.org/10.1182/blood-2018-07-861237
Autor:
Suhair Abdeen, Douglas B. Cines, Charuhas Deshpande, Nigar Anjuman Khurram, Emad Maraga, Kathleen T. Montone, Leslie A. Litzky, Abd Al-Roof Higazi, Michael Feldman, Khalil Bdeir, Mohamed Higazi, Rami Abu-Fanne, Samuel N. Heyman
Publikováno v:
British Journal of Haematology
Summary The inflammatory response to SARS/CoV‐2 (COVID‐19) infection may contribute to the risk of thromboembolic complications. α‐Defensins, antimicrobial peptides released from activated neutrophils, are anti‐fibrinolytic and prothrombotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd32ba9cd9e48a55b70a56524fe4d7ab
http://europepmc.org/articles/PMC8239944
http://europepmc.org/articles/PMC8239944
Autor:
Samuel N. Heyman, Mohamed Higazi, Rami Abu-Fanne, Aseel Masarwy, Douglas B. Cines, Emad Maraga, Abd Al-Roof Higazi, Suhair Abdeen, Khalil Bdeir
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231582 (2020)
PLoS ONE
PLoS ONE
Atherosclerosis, the predominant cause of death in well-resourced countries, may develop in the presence of plasma lipid levels within the normal range. Inflammation may contribute to lesion development in these individuals, but the underlying mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::573e4a22f1523e0c2798f0a8631608fd
https://doaj.org/article/7edbc5b3d3f044a396aa794b28049bca
https://doaj.org/article/7edbc5b3d3f044a396aa794b28049bca
Autor:
Hugh Hekierski, Abd Al-Roof Higazi, Philip Pastor, Serge Yarovoi, Douglas B. Cines, William M. Armstead
Publikováno v:
Translational Stroke Research. 10:104-111
The sole FDA-approved drug treatment for ischemic stroke is tissue-type plasminogen activator (tPA). However, upregulation of JNK mitogen-activated protein kinase (MAPK) and endothelin 1 (ET-1) by tPA after stroke contributes to impaired cerebrovascu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4a2bcc33debf69b417f8e039be7522
https://doi.org/10.1007/s12975-018-0617-z
https://doi.org/10.1007/s12975-018-0617-z
Autor:
Abd Al-Roof Higazi
Publikováno v:
Open Journal of Philosophy. :23-27
How did life come into existence on Earth? Although many scientific theories and hypotheses have been drawn, we have not yet been able to provide a detailed answer to this fundamental question. What if intelligent computers would someday be in a cond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bba8f485def6ef63a4bc325051798877
https://doi.org/10.4236/ojpp.2018.81003
https://doi.org/10.4236/ojpp.2018.81003