MR diffusion tensor imaging detects rapid microstructural changes in amygdala and hippocampus following fear conditioning in mice.

Autor: Abby Y Ding, Qi Li, Iris Y Zhou, Samantha J Ma, Gehua Tong, Grainne M McAlonan, Ed X Wu

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e51704 (2013)

BackgroundFollowing fear conditioning (FC), ex vivo evidence suggests that early dynamics of cellular and molecular plasticity in amygdala and hippocampal circuits mediate responses to fear. Such altered dynamics in fear circuits are thought to be et

Externí odkaz: https://doaj.org/article/5a10223bfde144dabc5f68a319f1291c

Tspyl2 Loss-of-Function Causes Neurodevelopmental Brain and Behavior Abnormalities in Mice

Autor: Siu Yuen Chan, Grainne M. McAlonan, Abby Y. Ding, Qi Li, Ed X. Wu, Tomy C. K. Hui, Kwun Kk Wong, Yu On Leung, Pak C. Sham, Ran Wei, Siew E. Chua, Charlton Cheung

Publikováno v: Behavior Genetics
Li, Q, Chan, S Y, Wong, K K, Wei, R, Leung, Y O, Ding, A Y, Hui, T C K, Cheung, C, Chua, S E, Sham, P C, Wu, E X & McAlonan, G M 2016, ' Tspyl2 Loss-of-Function Causes Neurodevelopmental Brain and Behavior Abnormalities in Mice ', Behavior Genetics, pp. 1-9 . https://doi.org/10.1007/s10519-015-9777-8

Testis specific protein, Y-encoded-like 2 (TSPYL2) regulates the expression of genes encoding glutamate receptors. Glutamate pathology is implicated in neurodevelopmental conditions such as autism spectrum disorder, attention deficit hyperactivity di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77830c5c6bad9bb32aee07162489594b
http://europepmc.org/articles/PMC4886156

Magnetic resonance spectroscopy reveals N-acetylaspartate reduction in hippocampus and cingulate cortex after fear conditioning

Autor: Abby Y. Ding, Iris Y. Zhou, Grainne M. McAlonan, Ed X. Wu, Qi Li

Publikováno v: Psychiatry Research: Neuroimaging. 204:178-183

The fear conditioning in rodents provides a valuable translational tool to investigate the neural basis of learning and memory and potentially the neurobiology of post-traumatic stress disorder (PTSD). Neurobiological changes induced by fear conditio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf0e497522f164b9eccaabb9150aac5
https://doi.org/10.1016/j.pscychresns.2012.09.010

Diffusion kurtosis imaging with tract-based spatial statistics reveals white matter alterations in preschool children

Autor: Ed X. Wu, Qinli Sun, Xianjun Li, Abby Y. Ding, Jian Yang, Mingxi Wan, Kevin C. Chan, Xin Hou, Jie Gao

Publikováno v: EMBC

Diffusion kurtosis imaging (DKI), an extension of diffusion tensor imaging (DTI), provides a practical method to describe non-Gaussian water diffusion in neural tissues. The sensitivity of DKI to detect the subtle changes in several chosen brain stru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb6c042c6b17f1d75854ac383c9a70f4
https://doi.org/10.1109/embc.2012.6346422

The effects of hypercapnia on DTI quantification in anesthetized rat brain

Autor: Ed X. Wu, Edward S. Hui, Abby Y. Ding

Publikováno v: 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

Diffusion Tensor Imaging (DTI) offers a valuable in vivo tool to characterize water diffusion behavior in biological tissues, particularly brain tissues. The accuracy of DTI derived parameters can directly affect the interpretation of underlying micr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e514cb3eddf9c421772bac6b1f511e4
https://doi.org/10.1109/iembs.2009.5333392