Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Abby M Green"'
Autor:
Amanda Heard, Jack H. Landmann, Ava R. Hansen, Alkmini Papadopolou, Yu-Sung Hsu, Mehmet Emrah Selli, John M. Warrington, John Lattin, Jufang Chang, Helen Ha, Martina Haug-Kroeper, Balraj Doray, Saar Gill, Marco Ruella, Katharina E. Hayer, Matthew D. Weitzman, Abby M. Green, Regina Fluhrer, Nathan Singh
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Loss of surface CD19 expression by leukemic cells leads to resistance and relapse to CD19-targeted CAR-T therapies. Here the authors show that loss of SPPL3 in malignant B cells results in hyperglycosylation of CD19.
Externí odkaz:
https://doaj.org/article/0f7c94a068e44180b9af36e2164d17d4
Autor:
Rachel A. DeWeerd, Eszter Németh, Ádám Póti, Nataliya Petryk, Chun-Long Chen, Olivier Hyrien, Dávid Szüts, Abby M. Green
Publikováno v:
Cell Reports, Vol 38, Iss 12, Pp 110555- (2022)
Summary: Mutational signatures defined by single base substitution (SBS) patterns in cancer have elucidated potential mutagenic processes that contribute to malignancy. Two prevalent mutational patterns in human cancers are attributed to the APOBEC3
Externí odkaz:
https://doaj.org/article/0976eac5cc3d4734bc831e3d308df896
Publikováno v:
Nat Genet
Mutational signatures associated with apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC)3 cytosine deaminase activity have been found in over half of cancer types, including some therapy-resistant and metastatic tumors. Driver m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43860e52f321f980d4818eec01259608
https://doi.org/10.1038/s41588-022-01196-8
https://doi.org/10.1038/s41588-022-01196-8
Autor:
Matthew D. Weitzman, Gerald B. Wertheim, Milan R. Savani, Morgann A. Reed, Katharina E. Hayer, Konstantin Budagyan, Abby M. Green
Mutational signatures in cancer genomes have implicated the APOBEC3 cytosine deaminases in oncogenesis, possibly offering a therapeutic vulnerability. Elevated APOBEC3B expression has been detected in solid tumors, but expression of APOBEC3A (A3A) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ef0826bbe1d1bea3d72b574ef0ab5c3
https://doi.org/10.1158/0008-5472.c.6509102.v1
https://doi.org/10.1158/0008-5472.c.6509102.v1
Autor:
Matthew D. Weitzman, Gerald B. Wertheim, Milan R. Savani, Morgann A. Reed, Katharina E. Hayer, Konstantin Budagyan, Abby M. Green
Raw data and analysis of RNA-sequencing and qPCR evaluation of APOBEC3 expression in AML.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ed6dc22f89b62e4a0caeb61ffc3c9c
https://doi.org/10.1158/0008-5472.22414877.v1
https://doi.org/10.1158/0008-5472.22414877.v1
Autor:
Meiqi Luo, Caroline Bartman, Rahul M. Kohli, Niklaus H. Evitt, Junwei Shi, Rachel A. DeWeerd, Yemin Lan, Kiara N. Berríos, Aleksia Barka, Tong Wang, Diqiu Ren, Abby M. Green
Publikováno v:
Nat Chem Biol
DNA deaminase enzymes play key roles in immunity and have recently been harnessed for their biotechnological applications. In base editors (BEs), the combination of DNA deaminase mutator activity with CRISPR-Cas localization confers the powerful abil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4718df94f1d5e88c35d7b1aa0651f982
https://doi.org/10.1038/s41589-021-00880-w
https://doi.org/10.1038/s41589-021-00880-w
Autor:
Rachel Johnston, Brendan Mathias, Stephanie J Crowley, Haley A Schmidt, Lynn S White, Nima Mosammaparast, Abby M Green, Jeffrey J Bednarski
Publikováno v:
EMBO reports. 24
Developing B cells generate DNA double-stranded breaks (DSBs) to assemble immunoglobulin receptor (Ig) genes necessary for the expression of a mature B cell receptor. These physiologic DSBs are made by the RAG endonuclease, which is comprised of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f9871b890e7d33a85b2eaa53864d9ff
https://doi.org/10.15252/embr.202255429
https://doi.org/10.15252/embr.202255429
Autor:
Rachel, DeWeerd, Abby M, Green
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2444
The human genome encodes eleven DNA cytidine deaminases in the AID/APOBEC family, which encompass endogenous roles ranging from genetic diversification of the immunoglobulin locus to virus restriction. All AID/APOBEC functions are enabled by their ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::728e6c54541175c5d3a10befad07dcc1
https://pubmed.ncbi.nlm.nih.gov/35290637
https://pubmed.ncbi.nlm.nih.gov/35290637
Autor:
William R Otto, Abby M. Green
Publikováno v:
Br J Haematol
Children with haematologic malignancies and haematopoietic stem cell transplant recipients are at high risk for invasive fungal diseases (IFD). There has been an increased number of at-risk children over the past two decades due to improvements in ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05eb343ceffe914acd9d061c166a65df
https://doi.org/10.1111/bjh.16452
https://doi.org/10.1111/bjh.16452
Autor:
Rachel DeWeerd, Abby M. Green
Publikováno v:
Methods in Molecular Biology ISBN: 9781071620625
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69d220890f8f04cf8b0aa9f3ac2ba687
https://doi.org/10.1007/978-1-0716-2063-2_10
https://doi.org/10.1007/978-1-0716-2063-2_10