Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Abby D. Benninghoff"'
Autor:
Preeti S. Chauhan, Abby D. Benninghoff, Olivia K. Favor, James G. Wagner, Ryan P. Lewandowski, Lichchavi D. Rajasinghe, Quan-Zhen Li, Jack R. Harkema, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionWorkplace exposure to respirable crystalline silica (cSiO2) has been epidemiologically linked to lupus. Consistent with this, repeated subchronic intranasal cSiO2 instillation in lupus-prone NZBWF1 mice induces inflammation-/autoimmune-re
Externí odkaz:
https://doaj.org/article/1e54e2a2b11e4dc2b1e9f441abbd8a28
Autor:
Lauren K. Heine, Abby D. Benninghoff, Elizabeth A. Ross, Lichchavi D. Rajasinghe, James G. Wagner, Ryan P. Lewandowski, Alexa L. Richardson, Quan-Zhen Li, John P. Buchweitz, Justin Zyskowski, Ashleigh N. Tindle, Anna E. Skedel, Nicholas J. Chargo, Laura R. McCabe, Jack R. Harkema, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Autoimmune diseases can be triggered by environmental toxicants such as crystalline silica dust (cSiO2). Here, we characterized the dose-dependent immunomodulation and toxicity of the glucocorticoid (GC) prednisone in a preclinical model that emulate
Externí odkaz:
https://doaj.org/article/9d62c3f710e94b838f4b340305d3c650
Autor:
Daphne M. Rodriguez, Korry J. Hintze, Giovanni Rompato, Eliza C. Stewart, Abbey H. Barton, Emily Mortensen-Curtis, Porter A. Green, Arnaud J. Van Wettere, Aaron J. Thomas, Abby D. Benninghoff
Publikováno v:
Nutrients, Vol 15, Iss 6, p 1338 (2023)
Consumption of the total Western diet (TWD) in mice has been shown to increase gut inflammation, promote colon tumorigenesis, and alter fecal microbiome composition when compared to mice fed a healthy diet, i.e., AIN93G (AIN). However, it is unclear
Externí odkaz:
https://doaj.org/article/799c514bff1a4497b84fd0bfb29007f7
Autor:
Lichchavi D. Rajasinghe, Quan-Zhen Li, Chengsong Zhu, Mei Yan, Preeti S. Chauhan, Kathryn A. Wierenga, Melissa A. Bates, Jack R. Harkema, Abby D. Benninghoff, James J. Pestka
Publikováno v:
Autoimmunity, Vol 53, Iss 7, Pp 415-433 (2020)
Inhalation of crystalline silica (cSiO2) in the workplace is etiologically linked to lupus and other autoimmune diseases. Exposing lupus-prone NZBWF1 mice to respirable cSiO2 unleashes a vicious cycle of inflammation and cell death in the lung that t
Externí odkaz:
https://doaj.org/article/88c45cb13ba94771ace3f1fe7e918ae4
Autor:
Lichchavi D. Rajasinghe, Melissa A. Bates, Abby D. Benninghoff, Kathryn A. Wierenga, Jack R. Harkema, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Repeated short-term intranasal instillation of lupus-prone mice with crystalline silica (cSiO2) induces inflammatory gene expression and ectopic lymphoid neogenesis in the lung, leading to early onset of systemic autoimmunity and rapid progression to
Externí odkaz:
https://doaj.org/article/1b39b5825b9f4754b52009ab265ddf9b
Publikováno v:
ACS Omega, Vol 5, Iss 17, Pp 10021-10033 (2020)
Externí odkaz:
https://doaj.org/article/6519b68f8446461da909c473d2e1b1d7
Autor:
Daphne M. Rodriguez, Korry J. Hintze, Giovanni Rompato, Arnaud J. Van Wettere, Robert E. Ward, Sumira Phatak, Canyon Neal, Tess Armbrust, Eliza C. Stewart, Aaron J. Thomas, Abby D. Benninghoff
Publikováno v:
Nutrients, Vol 14, Iss 24, p 5270 (2022)
Black raspberries (BRB) are rich in anthocyanins with purported anti-inflammatory properties. However, it is not known whether dietary supplementation would ameliorate Western-diet enhanced gut inflammation and colon tumorigenesis. We employed a mous
Externí odkaz:
https://doaj.org/article/1b34ff8753b14dc588622e38c522a6ec
Autor:
Preeti S. Chauhan, James G. Wagner, Abby D. Benninghoff, Ryan P. Lewandowski, Olivia K. Favor, Kathryn A. Wierenga, Kristen N. Gilley, Elizabeth A. Ross, Jack R. Harkema, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Occupational exposure to crystalline silica (cSiO2) is etiologically associated with systemic lupus erythematosus (lupus) and other autoimmune diseases. cSiO2's autoimmune effects in humans can be mimicked chronically in female lupus-prone NZBWF1 mic
Externí odkaz:
https://doaj.org/article/4bf1550374974527aa9665527a9e02d6
Autor:
Kathryn A. Wierenga, Rita S. Strakovsky, Abby D. Benninghoff, Lichchavi D. Rajasinghe, Adam L. Lock, Jack R. Harkema, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Lupus is a systemic autoimmune disease typified by uncontrolled inflammation, disruption of immune tolerance, and intermittent flaring – events triggerable by environmental factors. Preclinical and clinical studies reveal that consumption of the ma
Externí odkaz:
https://doaj.org/article/017f16990df246459ca40f252e6debe8
Autor:
Abby D. Benninghoff, Melissa A. Bates, Preeti S. Chauhan, Kathryn A. Wierenga, Kristen N. Gilley, Andrij Holian, Jack R. Harkema, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Exposure of lupus-prone female NZBWF1 mice to respirable crystalline silica (cSiO2), a known human autoimmune trigger, initiates loss of tolerance, rapid progression of autoimmunity, and early onset of glomerulonephritis. We have previously demonstra
Externí odkaz:
https://doaj.org/article/6a7cc55cbb8244a38e205d980fe5ec6a