Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Abbot F. Clark"'
Autor:
Shruti V. Patil, Balasankara Reddy Kaipa, Sujata Ranshing, Yogapriya Sundaresan, J. Cameron Millar, Bhavani Nagarajan, Charles Kiehlbauch, Qihong Zhang, Ankur Jain, Charles C. Searby, Todd E. Scheetz, Abbot F. Clark, Val C. Sheffield, Gulab S. Zode
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Mutations in myocilin (MYOC) are the leading known genetic cause of primary open-angle glaucoma, responsible for about 4% of all cases. Mutations in MYOC cause a gain-of-function phenotype in which mutant myocilin accumulates in the endoplas
Externí odkaz:
https://doaj.org/article/30e1fedfb0d445a39df2b98bbdbfd4a5
Publikováno v:
Cells, Vol 12, Iss 20, p 2452 (2023)
The glucocorticoid receptor (GR), including both alternative spliced isoforms (GRα and GRβ), has been implicated in the development of primary open-angle glaucoma (POAG) and iatrogenic glucocorticoid-induced glaucoma (GIG). POAG is the most common
Externí odkaz:
https://doaj.org/article/337a535934df48329a70fec94c948328
Autor:
Prabhavathi Maddineni, Ramesh B. Kasetti, Pinkal D. Patel, J. Cameron Millar, Charles Kiehlbauch, Abbot F. Clark, Gulab S. Zode
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-20 (2020)
Abstract Background Glaucoma is a leading neurodegenerative disease affecting over 70 million individuals worldwide. Early pathological events of axonal degeneration and retinopathy in response to elevated intraocular pressure (IOP) are limited and n
Externí odkaz:
https://doaj.org/article/5d98db75107e4e73813752674e1ac9f3
Autor:
Xiaobin Liu, Keith Ward, Christy Xavier, Jamieson Jann, Abbot F. Clark, Iok-Hou Pang, Hongli Wu
Publikováno v:
Redox Biology, Vol 8, Iss C, Pp 98-109 (2016)
Oxidative stress-induced retinal pigment epithelial (RPE) cell damage is an important factor in the pathogenesis of age-related macular degeneration (AMD). Previous studies have shown that RTA 408, a synthetic triterpenoid compound, potently activate
Externí odkaz:
https://doaj.org/article/1c0f93f6320e42dabc7b56db70e2761a
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169671 (2017)
The most common ocular side effect of glucocorticoid (GC) therapy is GC-induced ocular hypertension (OHT) and GC-induced glaucoma (GIG). GC-induced OHT occurs in about 40% of the general population, while the other 60% are resistant. This study aims
Externí odkaz:
https://doaj.org/article/b940cd2ecfeb4a2b931b5670b2aad6cf
Autor:
Shaohui Liu, Abbot F. Clark, Stephan Dixon, Priyanka Parekh, Weiming Mao, E. Martin, Davinder S. Grover, Jiannong Dai, Hannah C. Webber, Sherri L Harris, Ronald L. Fellman, Matthew E. Emanuel, David G. Godfrey, Louis B. Cantor, Oluwatosin U Smith, Vijay Krishna Raghunathan, Naga Pradeep Rayana, Michael Peng, Chenna Kesavulu Sugali, Michelle R. Butler
Publikováno v:
Am J Pathol
Glucocorticoid-induced glaucoma is a secondary open-angle glaucoma. About 40% of the general population may develop elevated intraocular pressure on prolonged glucocorticoid treatment secondary to damages in the trabecular meshwork (TM), a tissue tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0d463939cd2400f362740b8b879fdf
https://doi.org/10.1016/j.ajpath.2021.02.018
https://doi.org/10.1016/j.ajpath.2021.02.018
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153354 (2016)
PURPOSE:Fibrosis and a hypoxic environment are associated with the trabecular meshwork (TM) region in the blinding disease glaucoma. Hypoxia has been shown to alter DNA methylation, an epigenetic mechanism involved in regulating gene expression such
Externí odkaz:
https://doaj.org/article/e999b8c005c44e0083f97a7fc2cb0900
Publikováno v:
Expert Review of Ophthalmology. 15:145-157
Glucocorticoids (GCs) have unique actions in their combined anti-inflammatory and immunosuppressive activities and are among the most commonly prescribed drugs, particularly for inflammatory condit...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fad5ddf34990548412b2128900cc8c7
https://doi.org/10.1080/17469899.2020.1762488
https://doi.org/10.1080/17469899.2020.1762488
Autor:
Kimberly A. Fernandes, Jeffrey M. Harder, Laura B. Fornarola, Robert S. Freeman, Abbot F. Clark, Iok-Hou Pang, Simon W.M. John, Richard T. Libby
Publikováno v:
Neurobiology of Disease, Vol 46, Iss 2, Pp 393-401 (2012)
Glaucoma is a neurodegenerative disease characterized by the apoptotic death of retinal ganglion cells (RGCs). The primary insult to RGCs in glaucoma is thought to occur to their axons as they exit the eye in the optic nerve head. However, pathologic
Externí odkaz:
https://doaj.org/article/1fcb64a2048241429e4938ae34550e85
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 12
International Journal of Molecular Sciences, Vol 22, Iss 6178, p 6178 (2021)
Volume 22
Issue 12
International Journal of Molecular Sciences, Vol 22, Iss 6178, p 6178 (2021)
Glaucoma is a group of optic neuropathies that leads to irreversible vision loss. The optic nerve head (ONH) is the site of initial optic nerve damage in glaucoma. ONH-derived lamina cribrosa (LC) cells synthesize extracellular matrix (ECM) proteins<
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1708c415e594fe2d5d342ad1674631