Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Abbie Wong"'
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An in Vitro Assay Using Cultured Kupffer Cells Can Predict the Impact of Drug Conjugation on in Vivo Antibody Pharmacokinetics
Autor: David W. Meyer, Mechthild Jonas, Serena W. Wo, Joshua H. Hunter, Martha Anderson, Joe Z Hamilton, Lauren Bou, Sara Shum, Robert P. Lyon, Nicole M. Okeley, Abbie Wong
Publikováno v: Molecular pharmaceutics. 17(3)
While antibody-drug conjugates (ADCs) are advancing through clinical testing and receiving new marketing approvals, improvements to the technology continue to be developed in both academic and industrial laboratories. Among the key ADC attributes tha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d9b798b9be6fc75511535ab7292e0a
https://pubmed.ncbi.nlm.nih.gov/31976667
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7
Abstract 2888: Utilizing PDX models to better understand factors that predict response to SGN-CD228A, an antibody drug-conjugate (ADC) for solid tumors
Autor: Robert Lawrence, Kelly Hensley, Christopher Hale, John Gosink, Sean Allred, David Ortiz, Rachael Hu, Christine O'Day, Phillip M. Garfin, Timothy S. Lewis, Marsha Mason, Sharsti Sandall, Scott Peterson, Rebecca Mazahreh, Abbie Wong
Publikováno v: Cancer Research. 80:2888-2888
Patient-derived xenograft (PDX) models are widely recognized as a powerful preclinical tool. In contrast to cell line-derived xenograft (CDX) models, patient tumors are excised and implanted directly into mice and as such, retain tumor characteristic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33084f2cd650c356fda33dced9def7a6
https://doi.org/10.1158/1538-7445.am2020-2888
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8
Targeted Delivery of Cytotoxic NAMPT Inhibitors Using Antibody-Drug Conjugates
Autor: Julia H. Cochran, Paul G. Pittman, Steven Jin, Robert P. Lyon, Michelle Ulrich, Martha Anderson, Fu Li, Abbie Wong, Luke V. Loftus, Margo Zaval, Jay C. Nix, Jason Neale, Peter D. Senter, David W. Meyer, Jessica K. Simmons, Weiping Zeng, Andrew B. Waight, Christopher Scott Neumann, Kathleen C. Olivas
Publikováno v: Molecular cancer therapeutics. 17(12)
Antibody–drug conjugates (ADCs) are a therapeutic modality that enables the targeted delivery of cytotoxic drugs to cancer cells. Identification of active payloads with unique mechanisms of action is a key aim of research efforts in the field. Here
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc3e4e7f3cada75f5ac91f4c7c022d8a
https://pubmed.ncbi.nlm.nih.gov/30242091
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9
Abstract 983: Antibody-drug conjugates of NAMPT inhibitors: Discovery, optimization, and preclinical characterization
Autor: Michelle Ulrich, Steven Jin, Jessica K. Simmons, Fu Li, Robert P. Lyon, Abbie Wong, Weiping Zeng, Julia H. Cochran, Kung Pern Wang, Andrew B. Waight, Paul G. Pittman, David W. Meyer, Chris Neumann, Martha Anderson, Margo Zaval, Peter D. Senter, Kathleen C. Olivas, Luke V. Loftus
Publikováno v: Cancer Research. 79:983-983
Nicotinamide phosphoribosyltransferase (NAMPT) regulates the biosynthesis of NAD from nicotinamide via a salvage biosynthetic pathway. Inhibition of NAMPT depletes cellular NAD levels leading to disruption of energy metabolism and cell death. Non-tar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4619283e04f0c23f9c6b7da4df33e659
https://doi.org/10.1158/1538-7445.am2019-983
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