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pro vyhledávání: '"Abbie C. Mays"'
Autor:
GR Serjeant, Abbie C. Mays, Kirby D. Smith, C Sheils, Yen Pei C. Chang, DA Meyers, Shirley H. Purvis, George J. Dover
Publikováno v:
Blood. 80:816-824
Fetal hemoglobin (Hb F) production in sickle cell (SS) disease and in normal individuals varies over a 20-fold range and is under genetic control. Previous studies suggested that variant Hb F levels might be controlled by genetic loci separate from t
Autor:
Kirby D. Smith, Shirley H. Purvis, George J. Dover, Jeffrey R. Keefer, Tonya Schneidereith, Abbie C. Mays
Publikováno v:
Experimental hematology. 34(9)
Objective In vivo, several drugs have been shown to increase fetal hemoglobin (HbF), including 5-azacytidine (AZA), sodium butyrate (SB), and hydroxyurea (HU). Studies in K562 cells suggest that cyclic guanosine monophosphate (cGMP) is required for H