Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Abbi L Engel"'
Autor:
Mark A Kanow, Michelle M Giarmarco, Connor SR Jankowski, Kristine Tsantilas, Abbi L Engel, Jianhai Du, Jonathan D Linton, Christopher C Farnsworth, Stephanie R Sloat, Austin Rountree, Ian R Sweet, Ken J Lindsay, Edward D Parker, Susan E Brockerhoff, Martin Sadilek, Jennifer R Chao, James B Hurley
Publikováno v:
eLife, Vol 6 (2017)
Here we report multiple lines of evidence for a comprehensive model of energy metabolism in the vertebrate eye. Metabolic flux, locations of key enzymes, and our finding that glucose enters mouse and zebrafish retinas mostly through photoreceptors su
Externí odkaz:
https://doaj.org/article/aff27e94dd9b414d9153404c6b6c9551
Autor:
Siyan Zhu, Rong Xu, Abbi L. Engel, Yekai Wang, Rachel McNeel, James B. Hurley, Jennifer R. Chao, Jianhai Du
Publikováno v:
bioRxiv
It is known that metabolic defects in the retinal pigment epithelium (RPE) can cause degeneration of its neighboring photoreceptors in the retina, leading to retinal degenerative diseases such as age-related macular degeneration. However, how RPE met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd4ffbba9201ab7f8556c08f952b52c
https://doi.org/10.1101/2023.04.18.537355
https://doi.org/10.1101/2023.04.18.537355
Autor:
Abbi L. Engel, YeKai Wang, Thomas H. Khuu, Emily Worrall, Megan A. Manson, Rayne R. Lim, Kaitlen Knight, Aya Yanagida, Jian Hua Qi, Aravind Ramakrishnan, Richard G Weleber, Michael L. Klein, David J. Wilson, Bela Anand-Apte, James B. Hurley, Jianhai Du, Jennifer R. Chao
Publikováno v:
Exp Eye Res
Sorsby Fundus Dystrophy (SFD) is a rare form of macular degeneration that is clinically similar to age-related macular degeneration (AMD), and a histologic hallmark of SFD is a thick layer of extracellular deposits beneath the retinal pigment epithel
Autor:
Jianhai Du, Weiyong Shen, Abbi L. Engel, Yekai Wang, Jennifer R Chao, Rui Zhang, Bo Li, Mark C Gillies
Publikováno v:
J Proteome Res
Mitochondrial respiration in mammalian cells not only generates ATP to meet their own energy needs but also couples with biosynthetic pathways to produce metabolites that can be exported to support neighboring cells. However, how defects in mitochond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e960aa675107abf28119087713fe4606
https://doi.org/10.1101/2020.05.11.086827
https://doi.org/10.1101/2020.05.11.086827
Autor:
Yekai Wang, Jianhai Du, Jennifer R Chao, Abbi L. Engel, Jiancheng Huang, Allison Hauer, Chen Zhao, Michelle Yam, Rui Zhang, Daniel Lohner, Marlee Dinterman, Siyan Zhu
Publikováno v:
J Biol Chem
The retinal pigment epithelium (RPE) is a monolayer of pigmented cells between the choroid and the retina. RPE dysfunction underlies many retinal degenerative diseases, including age-related macular degeneration, the leading cause of age-related blin
Autor:
Jianhai Du, Abbi L. Engel, Martin Sadilek, Edward D Parker, Mark A Kanow, Austin M. Rountree, Kristine Tsantilas, Ian R. Sweet, Michelle M. Giarmarco, Ken J. Lindsay, Jonathan D. Linton, Stephanie R. Sloat, Christopher C. Farnsworth, Susan E. Brockerhoff, James B. Hurley, Connor Jankowski, Jennifer R Chao
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c1d9454b74830a4f58d933b2c7f01d9
https://doi.org/10.7554/elife.28899.014
https://doi.org/10.7554/elife.28899.014
Autor:
Megan A. Manson, Daniel Raftery, Danijel Djukovic, Haiwei Gu, Yekai Wang, Connor Jankowski, Jianhai Du, Jennifer R Chao, Abbi L. Engel, James B. Hurley, Kaitlen Knight
Metabolite transport is a major function of the retinal pigment epithelium (RPE) to support the neural retina. RPE dysfunction plays a significant role in retinal degenerative diseases. We have used mass spectrometry with 13C tracers to systematicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0f81c7d02d5e00671ae75425c431c2
https://europepmc.org/articles/PMC5546030/
https://europepmc.org/articles/PMC5546030/
Autor:
Connor Jankowski, Jennifer R Chao, Abbi L. Engel, Susan E. Brockerhoff, Stephanie R. Sloat, Ken J. Lindsay, Christopher C. Farnsworth, James B. Hurley, Michelle M. Giarmarco, Jonathan D. Linton, Mark A Kanow, Edward D Parker, Jianhai Du, Kristine Tsantilas, Martin Sadilek
Here we report multiple lines of evidence for a comprehensive model for retinal energy metabolism. Metabolic flux, locations of key enzymes and our finding that glucose enters the neural retina almost entirely through photoreceptors support a concept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed1883d14f2855b1681e95a6cf5d478
https://doi.org/10.1101/143347
https://doi.org/10.1101/143347
Autor:
Aravind Ramakrishnan, Van Tran, Martin Sadilek, James B. Hurley, Connor Jankowski, Jianhai Du, Kaitlen Knight, Jennifer R Chao, Anh Huan Vo, Aya Yanagida, Abbi L. Engel, Megan A. Manson
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(51)
The retinal pigment epithelium (RPE) is a monolayer of pigmented cells that requires an active metabolism to maintain outer retinal homeostasis and compensate for oxidative stress. Using 13C metabolic flux analysis in human RPE cells, we found that R
Publikováno v:
Biochemistry. 50:5971-5978
Ure2p of Candida albicans (Ure2(albicans) or CaUre2p) can be a prion in Saccharomyces cerevisiae, but Ure2p of Candida glabrata (Ure2(glabrata)) cannot, even though the Ure2(glabrata) N-terminal domain is more similar to that of the S. cerevisiae Ure