Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Abbe Haser"'
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2317 (2023)
The pharmaceutical industry is in the midst of a transition from traditional batch processes to continuous manufacturing. However, the challenges in making this transition vary depending on the selected manufacturing process. Compared with other oral
Externí odkaz:
https://doaj.org/article/b52a6104777d4356852a71ee8c7864c9
Publikováno v:
International Journal of Pharmaceutics. 630:122377
The purpose of this study was to evaluate if wet granule formation and drying could take place in a single operation by utilizing in-barrel drying. The drying kinetics of the formulation were studied in order to select appropriate processing paramete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cab55911106d4e62f7fa6a2bfe39b75e
https://doi.org/10.1016/j.ijpharm.2022.122377
https://doi.org/10.1016/j.ijpharm.2022.122377
Publikováno v:
AAPS PharmSciTech
Chemical degradation of drug substances remains a major drawback of extrusion. Larger-scale extrusion equipment has advantages over smaller equipment due to deeper flight elements and added flexibility in terms of screw design, unit operations, and r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb2aebb562ffb6a7ab7bdc74a7f60367
https://doi.org/10.1208/s12249-018-1162-5
https://doi.org/10.1208/s12249-018-1162-5
Publikováno v:
Molecular Pharmaceutics. 15:1226-1237
As the pipeline for poorly soluble compounds continues to grow, drug degradation during melt extrusion must be addressed. We present a novel method for stabilizing a thermally labile drug substance while preserving its physical stability and even imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7221e65e2048c58a9327efca5a79a0a8
https://doi.org/10.1021/acs.molpharmaceut.7b01057
https://doi.org/10.1021/acs.molpharmaceut.7b01057
Autor:
Abbe Haser, Feng Zhang
Publikováno v:
AAPS PharmSciTech. 19:978-990
The understanding of amorphous solid dispersions has grown significantly in the past decade. This is evident from the number of approved commercial amorphous solid dispersion products. While amorphous formulation is considered an enabling technology,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::189e10ff543f3c3a3fc326ef424db374
https://doi.org/10.1208/s12249-018-0953-z
https://doi.org/10.1208/s12249-018-0953-z
Publikováno v:
International Journal of Pharmaceutics. 524:55-64
Poorly water-soluble drug substances that exhibit high melting points are difficult to process by melt extrusion due to chemical instability at high temperatures required for processing. The purpose of this study was to extrude meloxicam (melting poi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de88b2430f7c6e5bd2193d5452f1b84
https://doi.org/10.1016/j.ijpharm.2017.03.070
https://doi.org/10.1016/j.ijpharm.2017.03.070
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 102
Our hypothesis is that melt extrusion is a more suitable processing method than spray drying to prepare amorphous solid dispersions of drugs with a high crystallization tendency. Naproxen-povidone K25 was used as the model system in this study. Napro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1b732d6d10d530d39325a72e73e912
https://pubmed.ncbi.nlm.nih.gov/28259831
https://pubmed.ncbi.nlm.nih.gov/28259831
Publikováno v:
Formulating Poorly Water Soluble Drugs ISBN: 9783319426075
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c934d4e3225459e6a09942539f9176c
https://doi.org/10.1007/978-3-319-42609-9_9
https://doi.org/10.1007/978-3-319-42609-9_9
