Pharmacophore-based, rationale design, and efficient synthesis of novel tetrahydrobenzo[b]thiophene candidates as potential dual Topo I/II inhibitors and DNA intercalators.

Autor: Nofal HR; Department of Chemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt., Al-Karmalawy AA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt.; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt., Elmaaty AA; Medicinal Chemistry Department, Faculty of Pharmacy, Port Said University, Port Said, Egypt., Ismail MF; Department of Chemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt., Ali AK; Department of Chemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt., Abbass EM; Department of Chemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt.

Publikováno v: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2024 Sep; Vol. 357 (9), pp. e2400217. Date of Electronic Publication: 2024 Jun 12.

Exploring the Antiproliferative Potency of Pyrido[2,3-d]Pyrimidine Derivatives: Studies on Design, Synthesis, Anticancer Evaluation, SAR, Docking, and DFT Calculations.

Autor: Abd-Alsalam E; Chemistry Department, Faculty of Science, Ain shams University, Abbassia, 11566, Cairo, Egypt., Hafez HN; National Research Center, Photochemistry Department (Heterocyclic Unit), Dokki, 12622, Cairo, Egypt., Assay MG; Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt., Ali AK; Chemistry Department, Faculty of Science, Ain shams University, Abbassia, 11566, Cairo, Egypt., El-Farargy AF; Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt., Abbass EM; Chemistry Department, Faculty of Science, Ain shams University, Abbassia, 11566, Cairo, Egypt.

Publikováno v: Chemistry & biodiversity [Chem Biodivers] 2024 Feb; Vol. 21 (2), pp. e202301682. Date of Electronic Publication: 2024 Jan 11.

Rational design and eco-friendly one-pot multicomponent synthesis of novel ethylidenehydrazineylthiazol-4(5H)-ones as potential apoptotic inducers targeting wild and mutant EGFR-TK in triple negative breast cancer.

Autor: Abbass EM; Department of Chemistry, Faculty of Science, Ain Shams University, Abbassiya 11566, Cairo, Egypt., Al-Karmalawy AA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta 34518, Egypt; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza 12566, Egypt. Electronic address: akarmalawy@horus.edu.eg., Sharaky M; Cancer Biology Department, Pharmacology Unit, National Cancer Institute (NCI), Cairo University, Cairo, Egypt., Khattab M; Office of Research, University of Western Australia, Perth, Australia; Department of Chemistry of Natural and Microbial Products, Division of Pharmaceutical and Drug Industries, National Research Centre, Cairo, Egypt., Alzahrani AYA; Department of Chemistry, Faculty of Science and Arts, King Khalid University, Mohail Assir, Saudi Arabia., Hassaballah AI; Department of Chemistry, Faculty of Science, Ain Shams University, Abbassiya 11566, Cairo, Egypt.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2024 Jan; Vol. 142, pp. 106936. Date of Electronic Publication: 2023 Oct 24.

Design, efficient synthesis, docking studies, and anticancer evaluation of new quinoxalines as potential intercalative Topo II inhibitors and apoptosis inducers.

Autor: Abbass EM; Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo 11566, Egypt., Khalil AK; Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo 11566, Egypt., Mohamed MM; Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo 11566, Egypt., Eissa IH; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt. Electronic address: Ibrahimeissa@azhar.edu.eg., El-Naggar AM; Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo 11566, Egypt. Electronic address: elsayedam@sci.asu.edu.eg.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2020 Nov; Vol. 104, pp. 104255. Date of Electronic Publication: 2020 Sep 02.