Design, Synthesis, and Docking of Novel Tropane Hybrids as Potent Hsp90 Inhibitors with Potential Anti-Breast Cancer Activity.

Autor: Abbas EMH; Department of Chemistry of Natural and Microbial Products, National Research Centre, Cairo, 12622, Egypt., Sabour R; Department of Pharmaceutical Medicinal Chemistry and Drug Design, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt., Alsaiari NA; Department of Chemistry, Faculty of Science and Arts at Sharurah, Najran University, Najran 11001, Saudi Arabia., Medrasi HY; Department of Chemistry, Faculty of Science, University of Jeddah, Jeddah, Saudi Arabia., Kassem AF; Chemistry Department, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia., Farghaly TA; Department of Chemistry, Faculty of Science, Umm Al-Qura University, Makkah, Saudi Arabia.; Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt.

Publikováno v: Current medicinal chemistry [Curr Med Chem] 2024 Sep 13. Date of Electronic Publication: 2024 Sep 13.

Synthesis of tricyclic and tetracyclic benzo[6,7]cycloheptane derivatives linked morpholine moiety as CDK2 inhibitors.

Autor: Farghaly TA; Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia., Abbas EMH; Chemistry of National and Microbial Products Department, National Research Centre, Giza, Egypt., Al-Sheikh MA; Department of Chemistry, Faculty of Science, University of Jeddah, AlFaisaliah, Jeddah, Saudi Arabia., Medrasi HY; Department of Chemistry, Faculty of Science, University of Jeddah, Jeddah, Saudi Arabia., Masaret GS; Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia., Pashameah RA; Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia., Qurban J; Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia., Harras MF; Department of Pharmaceutical Medicinal Chemistry and Drug Design, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.

Publikováno v: Drug development research [Drug Dev Res] 2023 Sep; Vol. 84 (6), pp. 1127-1141. Date of Electronic Publication: 2023 May 12.

Novel sulfonyl thiazolyl-hydrazone derivatives as EGFR inhibitors: Design, synthesis, biological evaluation and molecular docking studies.

Autor: Farghaly TA; Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt. Electronic address: thoraya-f@cu.edu.eg., Abbas EMH; Department of Chemistry, Natural and Microbial Products, National Research Center, Dokki, Cairo, Egypt., Al-Soliemy AM; Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah Almukaramah, Saudi Arabia., Sabour R; Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt., Shaaban MR; Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah Almukaramah, Saudi Arabia. Electronic address: rabiemohamed@hotmail.com.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2022 Apr; Vol. 121, pp. 105684. Date of Electronic Publication: 2022 Feb 15.

Novel anti-tubercular and antibacterial based benzosuberone-thiazole moieties: Synthesis, molecular docking analysis, DNA gyrase supercoiling and ATPase activity.

Autor: Omar MA; Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Division, National Research Center, 33 El Bohouth St.(former El Tahrir St.) Dokki, Giza P.O.box 12622, Egypt., Masaret GS; Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah Almukkarramah, Saudi Arabia., Abbas EMH; Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Division, National Research Center, 33 El Bohouth St.(former El Tahrir St.) Dokki, Giza P.O.box 12622, Egypt., Abdel-Aziz MM; The Regional Center for Mycology and Biotechnology, Al-Azhar University, Cairo, Egypt., Harras MF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt., Farghaly TA; Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt. Electronic address: thoraya-f@hotmail.com.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2020 Nov; Vol. 104, pp. 104316. Date of Electronic Publication: 2020 Sep 24.

New 4-phenylcoumarin derivatives as potent 3C protease inhibitors: Design, synthesis, anti-HAV effect and molecular modeling.

Autor: Kassem AF; Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, 33 El Bohouth St., Dokki, Giza, p.o.box 12622, Egypt., Batran RZ; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, 33 El Bohouth St., Dokki, Giza, p.o. box 12622, Egypt. Electronic address: rasha_batran@yahoo.com., Abbas EMH; Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, 33 El Bohouth St., Dokki, Giza, p.o.box 12622, Egypt., Elseginy SA; Green Chemistry Department, Chemical Industries Research Division, National Research Centre, 33 El Bohouth St., Dokki, Giza, p.o. box 12622, Egypt., Shaheen MNF; Environmental Virology Laboratory, Water pollution Research Department, Environmental Research Division, National Research Centre, 33 El Bohouth St., Dokki, Giza, p.o. box 12622, Egypt., Elmahdy EM; Environmental Virology Laboratory, Water pollution Research Department, Environmental Research Division, National Research Centre, 33 El Bohouth St., Dokki, Giza, p.o. box 12622, Egypt.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2019 Apr 15; Vol. 168, pp. 447-460. Date of Electronic Publication: 2019 Feb 16.