Zobrazeno 1 - 10
of 727
pro vyhledávání: '"Abba J Kastin"'
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e69356 (2013)
Interleukin (IL)-15 is a ubiquitously expressed cytokine that in the basal state is mainly localized intracellularly, including the nucleus. Unexpectedly, tumor necrosis factor-α (TNF) time-dependently induced nuclear export of IL-15Rα and IL15. Th
Externí odkaz:
https://doaj.org/article/c32587ac6e204950809c020fd8830f83
Autor:
Yi He, Qijing Bo, Zhen Mao, Jian Yang, Min Liu, Haixia Wang, Abba J. Kastin, Weihong Pan, Chuanyue Wang, Zuoli Sun
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
Our previous studies documented that interleukin-15 receptor α (IL-15Rα) knockout (KO) mice exhibited hyperactivity, memory impairment, and desperate behavior, which are core features of schizophrenia and depression. Due to the overlapping symptomo
Externí odkaz:
https://doaj.org/article/2aaaf385e229450c99ab99481b3b7eee
Autor:
Yi He, Yuxin Yu, Yanan Li, Weicheng Duan, Zuoli Sun, Jian Yang, Abba J. Kastin, Weihong Pan, Yan Zhang, Kang Wang
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2021)
BackgroundPrevious studies of the functions of IL15Rα have been limited to immune activities and skeletal muscle development. Immunological factors have been identified as one of the multiple causes of psychosis, and neurological symptoms have been
Externí odkaz:
https://doaj.org/article/380bc4258a8c42c1901a161889b57b22
Autor:
Abba Kastin, Abba J. Kastin
Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbo
Autor:
Yi He, Qijing Bo, Zhen Mao, Jian Yang, Min Liu, Haixia Wang, Abba J. Kastin, Weihong Pan, Chuanyue Wang, Zuoli Sun
Publikováno v:
Frontiers in psychiatry. 13
Our previous studies documented that interleukin-15 receptor α (IL-15Rα) knockout (KO) mice exhibited hyperactivity, memory impairment, and desperate behavior, which are core features of schizophrenia and depression. Due to the overlapping symptomo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3c2860ed485f9ba31f79b9a03f0756
https://pubmed.ncbi.nlm.nih.gov/35356722
https://pubmed.ncbi.nlm.nih.gov/35356722
Autor:
Jianliang Zhang, Zhenrong Zhang, Jia Zhou, Xuequan Zhu, Xiaojun Wu, Zuoli Sun, Xiaomin Wang, Jian Yang, Yi He, Weihong Pan, Yanli Pan, Junhua Guo, Abba J. Kastin, Chuanyue Wang, Zhimin Wang, Guangping Zhang
Publikováno v:
Current Molecular Medicine. 19:560-569
Background: Schizophrenia is a complex and debilitating mental disorder with strong heritability. Its pathogenesis involves immune dysregulation. Interleukin 15 and interleukin 15 receptor alpha(IL-15Rα) are classical immune molecules. They also hel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3339bbe9fa2182cad5bb76f7caf8c6b2
https://doi.org/10.2174/1566524019666190617172054
https://doi.org/10.2174/1566524019666190617172054
Autor:
Eliezer Masliah, Abba J. Kastin, Thomas Lake, Alan D. Snow, Paula Y. Choi, Lesley Larsen, Judy Cam, Steven G. Wood, Joel Cummings, Qubai Hu, Edward Rockenstein, Weihong Pan, Stephen Lorimer, Beth P. Nguyen, Daniel A. Kirschner, Rudolph E. Tanzi, Gerardo M. Castillo
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-28 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-28 (2019)
Brain aging and Alzheimer’s disease both demonstrate the accumulation of beta-amyloid protein containing “plaques” and tau protein containing “tangles” that contribute to accelerated memory loss and cognitive decline. In the present investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d975ef56ab3bc2942bb6948abcd20e4
http://europepmc.org/articles/PMC6365538
http://europepmc.org/articles/PMC6365538
Autor:
Weihong Pan, Abba J. Kastin
Publikováno v:
The Neuroscientist. 23:124-136
Sleep and its disorders are known to affect the functions of essential organs and systems in the body. However, very little is known about how the blood-brain barrier (BBB) is regulated. A few years ago, we launched a project to determine the impact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf600246ab58afc07527931550b3767
https://doi.org/10.1177/1073858416639005
https://doi.org/10.1177/1073858416639005
Autor:
Abba J. Kastin
Publikováno v:
Medicinal Chemistry. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ceaea3ea3eb1ee683d4e856003ba5688
https://doi.org/10.2174/157340641305170711185259
https://doi.org/10.2174/157340641305170711185259
Publikováno v:
The Journal of Neuroscience. 34:14697-14706
The blood–brain barrier (BBB) is a large regulatory and exchange interface between the brain and peripheral circulation. We propose that changes of the BBB contribute to many pathophysiological processes in the brain of subjects with chronic sleep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76bb95bdd2d77c2a4ee3dd2c0ba7174
https://doi.org/10.1523/jneurosci.2111-14.2014
https://doi.org/10.1523/jneurosci.2111-14.2014