Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Aayushi Mahajan"'
Autor:
Fahad Paryani, Ji-Sun Kwon, Christopher W. Ng, Kelly Jakubiak, Nacoya Madden, Kenneth Ofori, Alice Tang, Hong Lu, Shengnan Xia, Juncheng Li, Aayushi Mahajan, Shawn M. Davidson, Anna O. Basile, Caitlin McHugh, Jean Paul Vonsattel, Richard Hickman, Michael C. Zody, David E. Housman, James E. Goldman, Andrew S. Yoo, Vilas Menon, Osama Al-Dalahmah
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract The mechanisms underlying the selective regional vulnerability to neurodegeneration in Huntington’s disease (HD) have not been fully defined. To explore the role of astrocytes in this phenomenon, we used single-nucleus and bulk RNAseq, lip
Externí odkaz:
https://doaj.org/article/8951e53b83a446a78dbb4875a502960b
Autor:
Osama Al-Dalahmah, Michael G. Argenziano, Adithya Kannan, Aayushi Mahajan, Julia Furnari, Fahad Paryani, Deborah Boyett, Akshay Save, Nelson Humala, Fatima Khan, Juncheng Li, Hong Lu, Yu Sun, John F. Tuddenham, Alexander R. Goldberg, Athanassios Dovas, Matei A. Banu, Tejaswi Sudhakar, Erin Bush, Andrew B. Lassman, Guy M. McKhann, Brian J. A. Gill, Brett Youngerman, Michael B. Sisti, Jeffrey N. Bruce, Peter A. Sims, Vilas Menon, Peter Canoll
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Glioblastoma (GBM) diffusely infiltrates the brain and intermingles with non-neoplastic brain cells, including astrocytes, neurons and microglia/myeloid cells. This complex mixture of cell types forms the biological context for therapeutic r
Externí odkaz:
https://doaj.org/article/84706af8be0f4cffa61c89d018e75e54
Autor:
Pavan S. Upadhyayula, Dominique M. Higgins, Angeliki Mela, Matei Banu, Athanassios Dovas, Fereshteh Zandkarimi, Purvi Patel, Aayushi Mahajan, Nelson Humala, Trang T. T. Nguyen, Kunal R. Chaudhary, Lillian Liao, Michael Argenziano, Tejaswi Sudhakar, Colin P. Sperring, Benjamin L. Shapiro, Eman R. Ahmed, Connor Kinslow, Ling F. Ye, Markus D. Siegelin, Simon Cheng, Rajesh Soni, Jeffrey N. Bruce, Brent R. Stockwell, Peter Canoll
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Diet intervention is emerging as an option to improve cancer therapy. Here, the authors show that a diet with restrictive cysteine and methionine synergizes with a ferroptosis inducer to increase cell death and survival in glioma preclinical models.
Externí odkaz:
https://doaj.org/article/d887ba793f1142b985b1d97d66d45514
Autor:
Lisa Sprinzen, Franklin Garcia, Angeliki Mela, Liang Lei, Pavan Upadhyayula, Aayushi Mahajan, Nelson Humala, Lisa Manier, Richard Caprioli, Alfredo Quiñones-Hinojosa, Patrizia Casaccia, Peter Canoll
Publikováno v:
Cells, Vol 13, Iss 3, p 219 (2024)
Isocitrate Dehydrogenase-1 (IDH1) is commonly mutated in lower-grade diffuse gliomas. The IDH1R132H mutation is an important diagnostic tool for tumor diagnosis and prognosis; however, its role in glioma development, and its impact on response to the
Externí odkaz:
https://doaj.org/article/29984ddfb1b640858558c0a9d472a605
Autor:
Trang T. T. Nguyen, Enyuan Shang, Chang Shu, Sungsoo Kim, Angeliki Mela, Nelson Humala, Aayushi Mahajan, Hee Won Yang, Hasan Orhan Akman, Catarina M. Quinzii, Guoan Zhang, Mike-Andrew Westhoff, Georg Karpel-Massler, Jeffrey N. Bruce, Peter Canoll, Markus D. Siegelin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Glioblastoma patients are treated with Aurora kinase A (AURKA) inhibitors but resistance can occur. Here, the authors show that AURKA inhibition induces metabolic reprogramming, which leads to increased mitochondrial activity and inhibition of oxidat
Externí odkaz:
https://doaj.org/article/f4ce109d7c6840f1a279ca28a9499ce7
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Neurodegenerative dementias are the most common group of neurodegenerative diseases affecting more than 40 million people worldwide. One of these diseases is frontotemporal dementia (FTD), an early onset dementia and one of the leading causes of deme
Externí odkaz:
https://doaj.org/article/18ebd0a1b7c642c4ba21658bca7a396c
Autor:
Adam M. Sonabend, Peter Canoll, Raul Rabadan, Amy B. Heimberger, Maciej S. Lesniak, Craig Horbinski, Uttiya Basu, Gerson Rothschild, Ting Xiao, Catalina Lee-Chang, Edgar González-Buendia, Daniel Y. Zhang, Li Chen, Crismita Dmello, Angeliki Mela, Ganesh Rao, Aayushi Mahajan, Víctor A. Arrieta, Brice Laffleur, Takashi Tsujiuchi, Junfei Zhao, Joshua R. Kane
Purpose:Cancer immunoediting shapes tumor progression by the selection of tumor cell variants that can evade immune recognition. Given the immune evasion and intratumor heterogeneity characteristic of gliomas, we hypothesized that CD8+ T cells mediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222bb73485325ab3732b6f8c41e5d2d1
https://doi.org/10.1158/1078-0432.c.6529464
https://doi.org/10.1158/1078-0432.c.6529464
Autor:
Adam M. Sonabend, Peter Canoll, Raul Rabadan, Amy B. Heimberger, Maciej S. Lesniak, Craig Horbinski, Uttiya Basu, Gerson Rothschild, Ting Xiao, Catalina Lee-Chang, Edgar González-Buendia, Daniel Y. Zhang, Li Chen, Crismita Dmello, Angeliki Mela, Ganesh Rao, Aayushi Mahajan, Víctor A. Arrieta, Brice Laffleur, Takashi Tsujiuchi, Junfei Zhao, Joshua R. Kane
Expression of upstream activators of the MAPK pathway correlates with functional activation of the ERK and p38 cascades. (A) Correlation between Braf expression and pERK in tumors from mice treated with anti-CD8+ (n=8) and isotype control (n=8) antib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aaad0d540c1bbc0a26e622d4e076fa2
https://doi.org/10.1158/1078-0432.22476687.v1
https://doi.org/10.1158/1078-0432.22476687.v1
Autor:
Markus D. Siegelin, Peter Canoll, Jeffrey N. Bruce, Georg Karpel-Massler, Catarina M. Quinzii, Mike-Andrew Westhoff, Elena Bianchetti, Giulio Kleiner, Maria J. Sanchez-Quintero, Consuelo Torrini, Chang Shu, Junfei Zhao, Aayushi Mahajan, Nelson Humala, Angeliki Mela, Enyuan Shang, Trang T.T. Nguyen, Yiru Zhang
Figure S1. Crizotinib resistant cells reveal a reprogrammed tumor metabolism. Figure S2. Crizotinib modulates fatty acid metabolism and mitochondrial parameters. Figure S3. Tracing analysis reveals distinct modulation of metabolism by MET inhibition.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3ca270b2531ae2a9908279f0411cd4
https://doi.org/10.1158/0008-5472.22423917.v1
https://doi.org/10.1158/0008-5472.22423917.v1
Autor:
Markus D. Siegelin, Peter Canoll, Jeffrey N. Bruce, Georg Karpel-Massler, Catarina M. Quinzii, Mike-Andrew Westhoff, Elena Bianchetti, Giulio Kleiner, Maria J. Sanchez-Quintero, Consuelo Torrini, Chang Shu, Junfei Zhao, Aayushi Mahajan, Nelson Humala, Angeliki Mela, Enyuan Shang, Trang T.T. Nguyen, Yiru Zhang
The receptor kinase c-MET has emerged as a target for glioblastoma therapy. However, treatment resistance emerges inevitably. Here, we performed global metabolite screening with metabolite set enrichment coupled with transcriptome and gene set enrich
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6927c0d5296b85502a38feeb20f8211
https://doi.org/10.1158/0008-5472.c.6511608.v1
https://doi.org/10.1158/0008-5472.c.6511608.v1