Zobrazeno 1 - 10
of 322
pro vyhledávání: '"Aatur D Singhi"'
Autor:
Shikai Hu, Jacquelyn O Russell, Silvia Liu, Catherine Cao, Jackson McGaughey, Ravi Rai, Karis Kosar, Junyan Tao, Edward Hurley, Minakshi Poddar, Sucha Singh, Aaron Bell, Donghun Shin, Reben Raeman, Aatur D Singhi, Kari Nejak-Bowen, Sungjin Ko, Satdarshan P Monga
Publikováno v:
eLife, Vol 10 (2021)
Expansion of biliary epithelial cells (BECs) during ductular reaction (DR) is observed in liver diseases including cystic fibrosis (CF), and associated with inflammation and fibrosis, albeit without complete understanding of underlying mechanism. Usi
Externí odkaz:
https://doaj.org/article/01ba755c7dab41ab8470c5fde355f0f3
Autor:
Frances R Belmonte, Nikolaos Dedousis, Ian Sipula, Nikita A Desai, Aatur D Singhi, Yanxia Chu, Yingze Zhang, Sylvie Bannwarth, Véronique Paquis-Flucklinger, Lea Harrington, Sruti Shiva, Michael J Jurczak, Robert M O'Doherty, Brett A Kaufman
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0203101 (2019)
Petite Integration Factor 1 (PIF1) is a multifunctional helicase present in nuclei and mitochondria. PIF1 knock out (KO) mice exhibit accelerated weight gain and decreased wheel running on a normal chow diet. In the current study, we investigated whe
Externí odkaz:
https://doaj.org/article/0257a012d4cf43d6868160c11cb2075b
Autor:
Brandon M. Lehrich, Junyan Tao, Silvia Liu, Theo Z. Hirsch, Tyler M. Yasaka, Catherine Cao, Evan R. Delgado, Xiangnan Guan, Shan Lu, Long Pan, Yuqing Liu, Sucha Singh, Minakshi Poddar, Aaron Bell, Aatur D. Singhi, Jessica Zucman-Rossi, Yulei Wang, Satdarshan P. Monga
Publikováno v:
JHEP Reports, Vol 6, Iss 12, Pp 101186- (2024)
Background & Aims: Patients with β-catenin (encoded by CTNNB1)-mutated hepatocellular carcinoma (HCC) demonstrate heterogenous responses to first-line immune checkpoint inhibitors (ICIs). Precision-medicine based treatments for this subclass are cur
Externí odkaz:
https://doaj.org/article/4f777bb4aa9a490d898831e24d76a10d
Autor:
Yi Xu, Michael H. Nipper, Angel A. Dominguez, Zhenqing Ye, Naoki Akanuma, Kevin Lopez, Janice J. Deng, Destiny Arenas, Ava Sanchez, Francis E. Sharkey, Colin M. Court, Aatur D. Singhi, Huamin Wang, Martin E. Fernandez-Zapico, Lu-Zhe Sun, Siyuan Zheng, Yidong Chen, Jun Liu, Pei Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Animal studies have demonstrated the ability of pancreatic acinar cells to transform into pancreatic ductal adenocarcinoma (PDAC). However, the tumorigenic potential of human pancreatic acinar cells remains under debate. To address this gap
Externí odkaz:
https://doaj.org/article/3ae4e657182c429c839f4021884860ba
Autor:
Biki Gupta, Ravi Prakash Rai, Pabitra B. Pal, Daniel Rossmiller, Sudrishti Chaudhary, Anna Chiaro, Shannon Seaman, Aatur D. Singhi, Silvia Liu, Satdarshan P. Monga, Smita S. Iyer, Reben Raeman
Publikováno v:
Cells, Vol 13, Iss 9, p 756 (2024)
Integrin α4β7+ T cells perpetuate tissue injury in chronic inflammatory diseases, yet their role in hepatic fibrosis progression remains poorly understood. Here, we report increased accumulation of α4β7+ T cells in the liver of people with cirrho
Externí odkaz:
https://doaj.org/article/6540ae1506484a7ca9b22bec051b0339
Autor:
Xinran Cai, Sihan Li, Xuemei Zeng, Meishu Xu, Zehua Wang, Aatur D. Singhi, Daolin Tang, Song Li, Nathan A. Yates, Da Yang, Wen Xie
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 3, Pp 473-495 (2023)
Background & Aims: Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer deaths in the United States. Tyrosine sulfation, catalyzed by the tyrosylprotein sulfotransferase 2 (TPST2), is a post-translational modification essenti
Externí odkaz:
https://doaj.org/article/bcdae69c39064ff095dccd2b3747daef
Autor:
Sojin Lee, Taofeek O. Usman, Jun Yamauchi, Goma Chhetri, Xingchun Wang, Gina M. Coudriet, Cuiling Zhu, Jingyang Gao, Riley McConnell, Kyler Krantz, Dhivyaa Rajasundaram, Sucha Singh, Jon Piganelli, Alina Ostrowska, Alejandro Soto-Gutierrez, Satdarshan P. Monga, Aatur D. Singhi, Radhika Muzumdar, Allan Tsung, H. Henry Dong
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 14 (2022)
Hepatic inflammation is culpable for the evolution of asymptomatic steatosis to nonalcoholic steatohepatitis (NASH). Hepatic inflammation results from abnormal macrophage activation. We found that FoxO1 links overnutrition to hepatic inflammation by
Externí odkaz:
https://doaj.org/article/2b970c28217f4f17825383167b76ab08
Publikováno v:
Gastroenterology. 164:898-905
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::276658d71874926d774fa13ce5a2a50f
https://doi.org/10.1053/j.gastro.2023.02.026
https://doi.org/10.1053/j.gastro.2023.02.026
Autor:
Robert E. Schoen, Lisa A. Boardman, Marcia Cruz-Correa, Ajay Bansal, David Kastenberg, Chin Hur, Lynda Dzubinski, Sharon F. Kaufman, Luz M. Rodriguez, Ellen Richmond, Asad Umar, Eva Szabo, Andres Salazar, John McKolanis, Pamela Beatty, Reetesh K. Pai, Aatur D. Singhi, Camille M. Jacqueline, Riyue Bao, Brenda Diergaarde, Ryan P. McMurray, Carrie Strand, Nathan R. Foster, David M. Zahrieh, Paul J. Limburg, Olivera J. Finn
Publikováno v:
Clinical Cancer Research. 29:1678-1688
ObjectiveVaccines against antigens expressed on adenomas could prevent new adenoma formation. We assessed whether a MUC1 peptide vaccine produces an immune response and prevents subsequent colonic adenoma formation.DesignMulticenter, double blind, pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c67077ef40b3497c183ec52888740b
https://doi.org/10.1158/1078-0432.ccr-22-3168
https://doi.org/10.1158/1078-0432.ccr-22-3168
Publikováno v:
Human Pathology. 132:126-134
Patients with inflammatory bowel disease (IBD) are at an increased risk for colorectal cancer. Currently, dysplasia is the best marker of CRC risk. Assessing dysplasia is a challenging task for pathologists as the longstanding inflammation causes mar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d2e3f06173af074e824cb90e517889
https://doi.org/10.1016/j.humpath.2022.06.018
https://doi.org/10.1016/j.humpath.2022.06.018