Zobrazeno 1 - 10
of 322
pro vyhledávání: '"Aatur D, Singhi"'
Autor:
Brandon M. Lehrich, Junyan Tao, Silvia Liu, Theo Z. Hirsch, Tyler M. Yasaka, Catherine Cao, Evan R. Delgado, Xiangnan Guan, Shan Lu, Long Pan, Yuqing Liu, Sucha Singh, Minakshi Poddar, Aaron Bell, Aatur D. Singhi, Jessica Zucman-Rossi, Yulei Wang, Satdarshan P. Monga
Publikováno v:
JHEP Reports, Vol 6, Iss 12, Pp 101186- (2024)
Background & Aims: Patients with β-catenin (encoded by CTNNB1)-mutated hepatocellular carcinoma (HCC) demonstrate heterogenous responses to first-line immune checkpoint inhibitors (ICIs). Precision-medicine based treatments for this subclass are cur
Externí odkaz:
https://doaj.org/article/4f777bb4aa9a490d898831e24d76a10d
Autor:
Yi Xu, Michael H. Nipper, Angel A. Dominguez, Zhenqing Ye, Naoki Akanuma, Kevin Lopez, Janice J. Deng, Destiny Arenas, Ava Sanchez, Francis E. Sharkey, Colin M. Court, Aatur D. Singhi, Huamin Wang, Martin E. Fernandez-Zapico, Lu-Zhe Sun, Siyuan Zheng, Yidong Chen, Jun Liu, Pei Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Animal studies have demonstrated the ability of pancreatic acinar cells to transform into pancreatic ductal adenocarcinoma (PDAC). However, the tumorigenic potential of human pancreatic acinar cells remains under debate. To address this gap
Externí odkaz:
https://doaj.org/article/3ae4e657182c429c839f4021884860ba
Autor:
Biki Gupta, Ravi Prakash Rai, Pabitra B. Pal, Daniel Rossmiller, Sudrishti Chaudhary, Anna Chiaro, Shannon Seaman, Aatur D. Singhi, Silvia Liu, Satdarshan P. Monga, Smita S. Iyer, Reben Raeman
Publikováno v:
Cells, Vol 13, Iss 9, p 756 (2024)
Integrin α4β7+ T cells perpetuate tissue injury in chronic inflammatory diseases, yet their role in hepatic fibrosis progression remains poorly understood. Here, we report increased accumulation of α4β7+ T cells in the liver of people with cirrho
Externí odkaz:
https://doaj.org/article/6540ae1506484a7ca9b22bec051b0339
Autor:
Xinran Cai, Sihan Li, Xuemei Zeng, Meishu Xu, Zehua Wang, Aatur D. Singhi, Daolin Tang, Song Li, Nathan A. Yates, Da Yang, Wen Xie
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 3, Pp 473-495 (2023)
Background & Aims: Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer deaths in the United States. Tyrosine sulfation, catalyzed by the tyrosylprotein sulfotransferase 2 (TPST2), is a post-translational modification essenti
Externí odkaz:
https://doaj.org/article/bcdae69c39064ff095dccd2b3747daef
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Primary sclerosing cholangitis (PSC) is a rare, chronic, cholestatic liver disease characterized by progressive inflammation and fibrosis of the bile ducts. We have previously demonstrated the importance of Wnt/β-catenin signaling in mouse
Externí odkaz:
https://doaj.org/article/ad44fe786d194eccb1d030e8ee13482c
Autor:
Toshifumi Sato, Kimberly Z. Head, Jiang Li, Christine E. Dolin, Daniel Wilkey, Nolan Skirtich, Katelyn Smith, Dylan D. McCreary, Sylvia Liu, Juliane I. Beier, Aatur D. Singhi, Ryan M. McEnaney, Michael L. Merchant, Gavin E. Arteel
Publikováno v:
Matrix Biology Plus, Vol 17, Iss , Pp 100127- (2023)
Although most work has focused on resolution of collagen ECM, fibrosis resolution involves changes to several ECM proteins. The purpose of the current study was twofold: 1) to examine the role of MMP12 and elastin; and 2) to investigate the changes i
Externí odkaz:
https://doaj.org/article/b4a3e19f54cd4396a9a5f48571ac9871
Autor:
Samer S. AlMasri, Mazen S. Zenati, Annissa Desilva, Ibrahim Nassour, Brian A. Boone, Aatur D. Singhi, David L. Bartlett, Lance A. Liotta, Virginia Espina, Patricia Loughran, Michael T. Lotze, Alessandro Paniccia, Herbert J. Zeh III, Amer H. Zureikat, Nathan Bahary
Publikováno v:
Cancer Medicine, Vol 10, Iss 20, Pp 7233-7241 (2021)
Abstract Introduction Preoperative autophagy inhibition with hydroxychloroquine (HCQ) in combination with gemcitabine in pancreatic adenocarcinoma (PDAC) has been shown to be safe and effective in inducing a serum biomarker response and increase rese
Externí odkaz:
https://doaj.org/article/22bcc880a5264081a326a90968f1c5d6
Autor:
Naomi Fei, Sijin Wen, Rajesh Ramanathan, Melissa E. Hogg, Amer H. Zureikat, Michael T. Lotze, Nathan Bahary, Aatur D. Singhi, Herbert J. Zeh, Brian A. Boone
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 5, Pp 1822-1829 (2021)
Abstract SMAD4, a tumor suppressor gene, is lost in up to 60%–90% of pancreatic adenocarcinomas (PDAs). Loss of SMAD4 allows tumor progression by upregulating autophagy, a cell survival mechanism that counteracts apoptosis and allows intracellular
Externí odkaz:
https://doaj.org/article/fc1b523b0b3a44e2a592d00a88565d98
Autor:
Sojin Lee, Taofeek O. Usman, Jun Yamauchi, Goma Chhetri, Xingchun Wang, Gina M. Coudriet, Cuiling Zhu, Jingyang Gao, Riley McConnell, Kyler Krantz, Dhivyaa Rajasundaram, Sucha Singh, Jon Piganelli, Alina Ostrowska, Alejandro Soto-Gutierrez, Satdarshan P. Monga, Aatur D. Singhi, Radhika Muzumdar, Allan Tsung, H. Henry Dong
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 14 (2022)
Hepatic inflammation is culpable for the evolution of asymptomatic steatosis to nonalcoholic steatohepatitis (NASH). Hepatic inflammation results from abnormal macrophage activation. We found that FoxO1 links overnutrition to hepatic inflammation by
Externí odkaz:
https://doaj.org/article/2b970c28217f4f17825383167b76ab08
Autor:
Shikai Hu, Jacquelyn O Russell, Silvia Liu, Catherine Cao, Jackson McGaughey, Ravi Rai, Karis Kosar, Junyan Tao, Edward Hurley, Minakshi Poddar, Sucha Singh, Aaron Bell, Donghun Shin, Reben Raeman, Aatur D Singhi, Kari Nejak-Bowen, Sungjin Ko, Satdarshan P Monga
Publikováno v:
eLife, Vol 10 (2021)
Expansion of biliary epithelial cells (BECs) during ductular reaction (DR) is observed in liver diseases including cystic fibrosis (CF), and associated with inflammation and fibrosis, albeit without complete understanding of underlying mechanism. Usi
Externí odkaz:
https://doaj.org/article/01ba755c7dab41ab8470c5fde355f0f3