Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Aateka Patel"'
Autor:
Aateka Patel, Ewelina Hoffman, Doug Ball, Jan Klapwijk, Rory T. Steven, Alex Dexter, Josephine Bunch, Daniel Baker, Darragh Murnane, Victoria Hutter, Clive Page, Lea Ann Dailey, Ben Forbes
Publikováno v:
Pharmaceutics, Vol 11, Iss 7, p 345 (2019)
‘Foamy’ alveolar macrophages (FAM) observed in nonclinical toxicology studies during inhaled drug development may indicate drug-induced phospholipidosis, but can also derive from adaptive non-adverse mechanisms. Orally administered amiodarone is
Externí odkaz:
https://doaj.org/article/44dbe4fdc29849178e81e17d591fdd1c
Autor:
Alex Dexter, Doug Ball, Aateka Patel, Clive P. Page, Lea Ann Dailey, Josephine Bunch, Ben Forbes, Jan Klapwijk, Rory T. Steven, Adam J. Taylor
Publikováno v:
Analytical and Bioanalytical Chemistry
Within drug development and pre-clinical trials, a common, significant and poorly understood event is the development of drug-induced lipidosis in tissues and cells. In this manuscript, we describe a mass spectrometry imaging strategy, involving repe
Autor:
Abigail Martin, Victoria Hutter, Abhinav Kumar, Doug Ball, Ewelina Hoffman, Val Millar, Aateka Patel, Rhamiya Mahendran, Lea Ann Dailey, Jan Klapwijk, Ben Forbes
Publikováno v:
Pharmaceutical Research
Hoffman, E, Patel, A, Ball, D, Klapwijk, J, Millar, V, Kumar, A, Martin, A, Mahendran, R, Dailey, L A, Forbes, B & Hutter, V 2017, ' Morphometric Characterization of Rat and Human Alveolar Macrophage Cell Models and their Response to Amiodarone using High Content Image Analysis ', Pharmaceutical Research, pp. 1-11 . https://doi.org/10.1007/s11095-017-2176-5
Hoffman, E, Patel, A, Ball, D, Klapwijk, J, Millar, V, Kumar, A, Martin, A, Mahendran, R, Dailey, L A, Forbes, B & Hutter, V 2017, ' Morphometric Characterization of Rat and Human Alveolar Macrophage Cell Models and their Response to Amiodarone using High Content Image Analysis ', Pharmaceutical Research, pp. 1-11 . https://doi.org/10.1007/s11095-017-2176-5
Purpose: Progress to the clinic may be delayed or prevented when vacuolated or “foamy” alveolar macrophages are observed during non-clinical inhalation toxicology assessment. The first step in developing methods to study this response in vitro is
Autor:
Lea Ann Dailey, Clive P. Page, Victoria Hutter, Josephine Bunch, Dough Ball, Daniel Baker, Darragh Murnane, Alex Dexter, Ewelina Hoffman, Jan Klapwijk, Aateka Patel, Rory T. Steven, Ben Forbes
Publikováno v:
Pharmaceutics
Volume 11
Issue 7
Pharmaceutics, Vol 11, Iss 7, p 345 (2019)
Volume 11
Issue 7
Pharmaceutics, Vol 11, Iss 7, p 345 (2019)
&lsquo
Foamy&rsquo
alveolar macrophages (FAM) observed in nonclinical toxicology studies during inhaled drug development may indicate drug-induced phospholipidosis, but can also derive from adaptive non-adverse mechanisms. Orally administer
Foamy&rsquo
alveolar macrophages (FAM) observed in nonclinical toxicology studies during inhaled drug development may indicate drug-induced phospholipidosis, but can also derive from adaptive non-adverse mechanisms. Orally administer
Autor:
Lea Ann Dailey, Ben Forbes, R.T.M. de Rosales, Stephen Clark, Arcadia Woods, Aateka Patel, Kavitha Sunassee, Domenico Spina, A. Babin-Morgan, Helen L. Collins, Yanira Riffo-Vasquez, Kenneth D. Bruce
Publikováno v:
Journal of Controlled Release
Woods, A, Patel, A, Spina, D, Riffo-Vasquez, Y, Babin-Morgan, A, De Rosales, R T M, Sunassee, K, Clark, S, Collins, H, Bruce, K, Dailey, L A & Forbes, B 2015, ' In vivo biocompatibility, clearance, and biodistribution of albumin vehicles for pulmonary drug delivery ', JOURNAL OF CONTROLLED RELEASE, vol. 210, pp. 1-9 . https://doi.org/10.1016/j.jconrel.2015.05.269
Woods, A, Patel, A, Spina, D, Riffo-Vasquez, Y, Babin-Morgan, A, De Rosales, R T M, Sunassee, K, Clark, S, Collins, H, Bruce, K, Dailey, L A & Forbes, B 2015, ' In vivo biocompatibility, clearance, and biodistribution of albumin vehicles for pulmonary drug delivery ', JOURNAL OF CONTROLLED RELEASE, vol. 210, pp. 1-9 . https://doi.org/10.1016/j.jconrel.2015.05.269
The development of clinically acceptable albumin-based nanoparticle formulations for use in pulmonary drug delivery has been hindered by concerns about the toxicity of nanomaterials in the lungs combined with a lack of information on albumin nanopart
Autor:
Stuart A. Jones, Ben Forbes, Lea Ann Dailey, Yanira Riffo-Vasquez, Marie-Christine Jones, Ewelina Hoffman, Aateka Patel, Clive P. Page, Anna Babin Morgan, Domenico Spina
Publikováno v:
Journal of Controlled Release. 183:94-104
To date, the role of nanoparticle surface hydrophobicity has not been investigated quantitatively in relation to pulmonary biocompatibility. A panel of nanoparticles spanning three different biomaterial types, pegylated lipid nanocapsules, polyvinyl
Autor:
Charles H. Knowles, H. Dent, J. Gahir, Y. Abbey, Sarantos Kaptanis, Sonal Arora, S. Dindyal, A. C. Katz-Summercorn, S. Hislop, Aateka Patel, G. Sharp, J. Davies, Nicholas R. A. Symons, James B Haddow, N. Yassin, A. Memarzadeh, H. West, D. Debnath, A. Kheraj, A. Currie, A. Lazaridis, Victor W S Kung, B. M. Stubbs, Uzair Ahmad, Aneel Bhangu, G. Garrett, Stephen Clark, S. Tayeh, S. Mallappa, Alex Aiken, Faisal Ali, H. Kaderbhai, S. Farag, Christopher P. Bretherton, I. Al-Shoek, Steven Williams
Publikováno v:
Hernia
PURPOSE: Evidence regarding whether or not antibiotic prophylaxis is beneficial in preventing post-operative surgical site infection in adult inguinal hernia repair is conflicting. A recent Cochrane review based on 17 randomised trials did not reach
Publikováno v:
Molecular pharmaceutics. 13(10)
There is a paucity of data describing the impact of salt counterions on the biological performance of inhaled medicines in vivo. The aim of this study was to determine if the coadministration of salt counterions influenced the tissue permeability and