Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Aasim Sheikh"'
Autor:
Zobair M. Younossi, Maria Stepanova, Mazen Noureddin, Kris V. Kowdley, Simone I. Strasser, Anita Kohli, Peter Ruane, Mitchell L. Shiffman, Aasim Sheikh, Nadege Gunn, Stephen H. Caldwell, Ryan S. Huss, Robert P. Myers, Vincent Wai‐Sun Wong, Naim Alkhouri, Zachary Goodman, Rohit Loomba
Publikováno v:
Hepatology Communications, Vol 5, Iss 7, Pp 1201-1211 (2021)
Patient‐reported outcomes (PROs) are important endpoints for clinical trials. The impact of investigational drugs on PROs of patients with advanced nonalcoholic steatohepatitis (NASH) was investigated. Patients with NASH with bridging fibrosis or c
Externí odkaz:
https://doaj.org/article/10bc3bc5921042808f8b0f85eb39a5a0
Autor:
Cynthia Levy, Deven Parmar, Andrew deLemos, Simona Rossi, Aasim Sheikh, Naga Chalasani, Nikolaos Pyrsopoulos, Edward Mena, David S. Goldberg, Stephen H. Caldwell, Farheen Shaikh, Ravi Ravinuthala, Raj Vuppalanchi, James D. Bainbridge
Publikováno v:
Journal of Hepatology. 76:75-85
Saroglitazar is a novel peroxisome proliferator-activated receptor (PPAR) agonist with dual agonistic properties (α/γ). Due to a strong mechanistic rationale, we aimed to test the safety and efficacy of saroglitazar in patients with primary biliary
Autor:
Naim Alkhouri, Anita Kohli, Nadege Gunn, Stephen H. Caldwell, Simone I. Strasser, Robert P. Myers, Mitchell L. Shiffman, Ryan S Huss, Peter Ruane, Zachary Goodman, Kris V. Kowdley, Zobair M. Younossi, Mazen Noureddin, Maria Stepanova, Vincent Wai-Sun Wong, Rohit Loomba, Aasim Sheikh
Publikováno v:
Hepatology Communications, Vol 5, Iss 7, Pp 1201-1211 (2021)
Hepatology Communications
Hepatology communications, vol 5, iss 7
Hepatology Communications
Hepatology communications, vol 5, iss 7
Patient‐reported outcomes (PROs) are important endpoints for clinical trials. The impact of investigational drugs on PROs of patients with advanced nonalcoholic steatohepatitis (NASH) was investigated. Patients with NASH with bridging fibrosis or c
Autor:
Laurent Peyrin-Biroulet, Ailsa Hart, Peter Bossuyt, Millie Long, Matthieu Allez, Pascal Juillerat, Alessandro Armuzzi, Edward V Loftus, Elham Ostad-Saffari, Astrid Scalori, Young S Oh, Swati Tole, Akiko Chai, Jennifer Pulley, Stuart Lacey, William J Sandborn, Humberto Aguilar, Tariq Ahmad, Evangelos Akriviadis, Xavier Aldeguer Mante, Istvan Altorjay, Ashwin Ananthakrishnan, Vibeke Andersen, Montserrat Andreu Garcia, Guy Aumais, Irit Avni-Biron, Jeffrey Axler, Kamran Ayub, Filip Baert, Mauro Bafutto, George Bamias, Isaac Bassan, Curtis Baum, Laurent Beaugerie, Brian Behm, Pradeep Bekal, Michael Bennett, Fernando Bermejo San Jose, Charles Bernstein, Dominik Bettenworth, Sudhir Bhaskar, Livia Biancone, Bahri Bilir, Michael Blaeker, Stuart Bloom, Verle Bohman, Francisco Javier Bosques Padilla, Yoram Bouhnik, Gerd Bouma, Raymond Bourdages, Stephan Brand, Brian Bressler, Markus Brückner, Carsten Buening, Franck Carbonnel, Thomas Caves, Jonathon Chapman, Jae Hee Cheon, Naoki Chiba, Camelia Chioncel, Dimitrios Christodoulou, Martin Clodi, Albert Cohen, Gino Roberto Corazza, Richard Corlin, Rocco Cosintino, Fraser Cummings, Robin Dalal, Silvio Danese, Marc De Maeyer, Carlos Fernando De Magalhães Francesconi, Aminda De Silva, Henry Debinski, Pierre Desreumaux, Olivier Dewit, Geert D'Haens, Sandra Di Felice Boratto, John Nik Ding, Tyler Dixon, Gerald Dryden, George Aaron Du Vall, Matthias Ebert, Ana Echarri Piudo, Robert Ehehalt, Magdy Elkhashab, Craig Ennis, Jason Etzel, Jan Fallingborg, Brian Feagan, Roland Fejes, Daniel Ferraz de Campos Mazo, Valéria Ferreira de Almeida Borges, Andreas Fischer, Alan Fixelle, Mark Fleisher, Sharyle Fowler, Bradley Freilich, Keith Friedenberg, Walter Fries, Csaba Fulop, Mathurin Fumery, Sergio Fuster, Gyula G Kiss, Santiago Garcia Lopez, Sonja Gassner, Kanwar Gill, Cyrielle Gilletta de Saint Joseph, Philip Ginsburg, Paolo Gionchetti, Eran Goldin, Adrian-Eugen Goldis, Hector Alejandro Gomez Jaramillo, Maciej Gonciarz, Glenn Gordon, Daniel Green, Jean-Charles Grimaud, Rogelio Guajardo Rodriguez, Zoltan Gurzo, Alexandra Gutierrez, Tibor Gyökeres, Ki Baik Hahm, Stephen Hanauer, John Hanson, William Harlan III, Peter Hasselblatt, Buhussain Hayee, Xavier Hebuterne, Peter Hendy, Melvin Heyman, Peter Higgins, Raouf Hilal, Pieter Hindryckx, Frank Hoentjen, Peter Hoffmann, Frank Holtkamp-Endemann, Gerald Holtmann, Gyula Horvat, Stefanie Howaldt, Samuel Huber, Ikechukwu Ibegbu, Maria Isabel Iborra Colomino, Peter Irving, Kim Isaacs, Kiran Jagarlamudi, Rajesh Jain, Sender Jankiel Miszputen, Jeroen Jansen, Jennifer Jones, John Karagiannis, Nicholas Karyotakis, Arthur Kaser, Lior Katz, Seymour Katz, Leo Katz, Nirmal Kaur, Edita Kazenaite, Reena Khanna, Sunil Khurana, Joo Sung Kim, Young-Ho Kim, Sung Kook Kim, Dongwoo Kim, Jochen Klaus, Dariusz Kleczkowski, Pavel Kohout, Bartosz Korczowski, Georgios Kouklakis, Ioannis Koutroubakis, Richard Krause, Tunde Kristof, Ian Kronborg, Annette Krummenerl, Limas Kupcinskas, Jorge Laborda Molteni, David Laharie, Adi Lahat-zok, Jonghun Lee, Kang-Moon Lee, Rupert Leong, Henry Levine, Jimmy Limdi, James Lindsay, Nilesh Lodhia, Edward Loftus, Randy Longman, Pilar Lopez Serrano, Edouard Louis, Maria Helena Louzada Pereira, John Lowe, Stefan Lueth, Milan Lukas, Giovanni Maconi, Finlay Macrae, Laszlo Madi-Szabo, Uma Mahadevan-Velayos, Everson Fernando Malluta, Fazia Mana, Peter Mannon, Gerasimos Mantzaris, Ignacio Marin Jimenez, Maria Dolores Martin Arranz, Radu-Bogdan Mateescu, Felipe Mazzoleni, Agnieszka Meder, Ehud Melzer, Jessica Mertens, Konstantinos Mimidis, Brent Mitchell, Tamas Molnar, Gregory Moore, Luis Alonso Morales Garza, Reme Mountifield, Vinciane Muls, Charles Murray, Bela Nagy, Markus Neurath, Augustin Nguyen, Remo Panaccione, William Pandak, Julian Panes Diaz, Jihye Park, Luca Pastorelli, Bhaktasharan Patel, Markus Peck-Radosavljevic, Gyula Pecsi, Farhad Peerani, Javier Perez Gisbert, Martin Pesta, Robert Petryka, Raymond Phillips, Marieke Pierik, Vijayalakshmi Pratha, Vlastimil Prochazka, Istvan Racz, Graham Radford-Smith, Daniel Ramos Castañeda, Odery Ramos Júnior, Jaroslaw Regula, Jean-Marie Reimund, Bryan Robbins, Xavier Roblin, Francesca Rogai, Gerhard Rogler, Jerzy Rozciecha, David Rubin, Azalia Yuriria Ruiz Flores, Maciej Rupinski, Grazyna Rydzewska, Sumona Saha, Simone Saibeni, Agnes Salamon, Zoltan Sallo, Bruce Salzberg, Douglas Samuel, Sunil Samuel, William Sandborn, Edoardo Vincenzo Savarino, Anja Schirbel, Robert Schnabel, Stefan Schreiber, John Scott, Shahriar Sedghi, Frank Seibold, Jakob Seidelin, Ursula Seidler, Ahmad Shaban, Ira Shafran, Aasim Sheikh, Alex Sherman, Haim Shirin, Patryk Smolinski, Geun Am Song, Konstantinos Soufleris, Alexander Speight, Dirk Staessen, Andreas Stallmach, Michael Staun, Daniel Stein, Hillary Steinhart, Jonathas Stifft, David Stokesberry, Andreas Sturm, Keith Sultan, Gyorgy Szekely, Kuldeep Tagore, Hugo Tanno, Lena Thin, Syed Thiwan, Carlton Thomas, Michal Tichy, Gabor Tamas Toth, Zsolt Tulassay, Jan Ulbrych, John Valentine, Marta Varga, Eduardo Vasconcellos, Byron Vaughn, Brenda Velasco, Francisco Velazquez, Severine Vermeire, Erica Villa, Aron Vincze, Harald Vogelsang, Miroslava Volfova, Lucine Vuitton, Petr Vyhnalek, Peter Wahab, Jens Walldorf, Mattitiahu Waterman, John Weber, L. Michael Weiss, Anna Wiechowska-Kozlowska, Elise Wiesner, Thomas Witthoeft, Robert Wohlman, Barbara Wozniak-Stolarska, Bruce Yacyshyn, Byong-Duk Ye, Ziad Younes, Lígia Yukie Sassaki, Cyrla Zaltman, Stefan Zeuzem
Publikováno v:
Lancet Gastroenterology & Hepatology, 7, 2, pp. 128-140
Lancet Gastroenterology & Hepatology, 7, 128-140
lancet. Gastroenterology & hepatology. Elsevier Limited
Lancet Gastroenterology & Hepatology, 7, 128-140
lancet. Gastroenterology & hepatology. Elsevier Limited
Summary Background Etrolizumab is a gut-targeted, anti-β7 integrin, monoclonal antibody. In an earlier phase 2 induction study, etrolizumab significantly improved clinical remission compared with placebo in patients with moderately to severely activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b54d0fd6c6b85ddd5e74fb05debd3e01
https://repository.ubn.ru.nl/handle/2066/252158
https://repository.ubn.ru.nl/handle/2066/252158
Autor:
Severine Vermeire, Peter L Lakatos, Timothy Ritter, Stephen Hanauer, Brian Bressler, Reena Khanna, Kim Isaacs, Saumin Shah, Alysha Kadva, Helen Tyrrell, Young S Oh, Swati Tole, Akiko Chai, Jennifer Pulley, Christopher Eden, Wenhui Zhang, Brian G Feagan, Philip Abraham, Mauro Acir Crippa Júnior, Humberto Aguilar, Tasneem Ahmed, Istvan Altorjay, Vibeke Andersen, Ronen Arai, Hays Arnold, Karlee Ausk, Jeffrey Axler, Kamran Ayub, Avinash Balekuduru, Guerino Barbalaco Neto, Isaac Bassan, Brian Behm, Pradeep Bekal, Shobna Bhatia, Barnabas Bod, Carlos Eduardo Brandão Mello, Julia Brandeburova, Johannes Breedt, Ivan Chopey, Michael Connor, Richard Corlin, Carlos Alejandro Cortez Hernandez, Arijit De, Alexander de Sá Rolim, Sandra Di Felice Boratto, Tyler Dixon, Debora Dourado Poli, David Dresner, George Aaron Du Vall, Matthias Ebert, Robert Ehehalt, Atilla Ertan, Ruben Escarcega Valencia, Jason Etzel, Jan Fallingborg, Brian Feagan, Miroslav Fedurco, Enrique Fernandez Castro, Valéria Ferreira de Almeida Borges, Mark Finklestein, Andreas Fischer, Mark Fleisher, Angel Ricardo Flores Rendon, Ronald Fogel, Osvaldo Franceschi Junior, Curtis Freedland, David Gatof, Kanwar Gill, Henning Glerup, Vardaraj Gokak, Eran Goldin, Hector Alejandro Gomez Jaramillo, Nitin Gupta, Zoltan Gurzo, Olga Gyrina, Mohammed Aejaz Habeeb, Robert Hardi, William Harlan, Ammar Hemaidan, Melvin Heyman, Peter Hoffmann, William Holderman, Frank Holtkamp-Endemann, Gyula Horvat, Eran Israeli, Sender Jankiel Miszputen, Søren Jensen, Kenneth Johnson, Jennifer Jones, Osvaldo Junior, Barbora Kadleckova, Mukesh Kalla, Zsuzsanna Kallo, Nicholas Karyotakis, Lior Katz, Leo Katz, Nirmal Kaur, Pavel Kohout, Peter Lakatos, Emmanuel Larriva de los Reyes, Robert Lee, Bernard Leman, Olena Levchenko, Henry Levine, Lúcia Libanez Bessa Campelo Braga, Edward Loftus, Tetiana Lohdanidi, Randy Longman, Josefina Lozano, Christian Maaser, Laszlo Madi-Szabo, Everson Fernando Malluta, John Marshall, Francisca Martinez Silva, Kenneth Maynard, Agnieszka Meder, Chetan Mehta, Peter Minarik, Joachim Mueller, Shrikant Mukewar, Bela Nagy, Vasyl Neiko, Markus Neurath, Brian Nichol, James Novick, Nitin Pai, William Pandak, Sarat Panigrahi, Ulrich-Frank Pape, Raymundo Paraná, Nimisha Parekh, Bhaktasharan Patel, Gyula Pecsi, Sergio Peralta, Martin Pesta, Eva Peterfai, Carlo Petruzzellis, Robert Petryka, Roberta Pica, Carlos Piniella, Vijayalakshmi Pratha, Vlastimil Prochazka, Sergey Prokopchuk, Ludmyla Prystupa, Amarender Puri, Tova Rainis, Bhashyakarla Ramesh Kumar, Odery Ramos Júnior, Iaroslava Rishko, Bryan Robbins, Elizabeth Rock, Marcelo Rodrigues Borba, Miguel Rodriguez, Jerzy Rozciecha, Azalia Yuriria Ruiz Flores, Grazyna Rydzewska, Rifaat Safadi, Simone Saibeni, Anja Schirbel, Wolff Schmiegel, Róbert Schnabel, Herbert Schneider, Armando Segui, Jakob Seidelin, Ursula Seidler, Joseph Sellin, Ira Shafran, Aasim Sheikh, Alex Sherman, Haim Shirin, Akash Shukla, Firdous Siddiqui, Robert Sike, Ajit Sood, Andreas Stallmach, Mykola Stanislavchuk, Michael Staun, Daniel Stein, Alon Steinberg, Hillary Steinhart, Jonathas Stifft, Rakesh Tandon, Vishwanath Tantry, Syed Thiwan, Matthias Treiber, Jan Ulbrych, John Valentine, Rajeev Vasudeva, Byron Vaughn, Brenda Velasco, Aron Vincze, Miroslava Volfova, Mattitiahu Waterman, L. Michael Weiss, Elise Wiesner, Alonzo Williams, Thomas Witthoeft, Robert Wohlman, John Wright, Jesus Kazuo Yamamoto Furusho, Ziad Younes, Khurshid Yousuf, Yaroslav Zborivskyy, Stefan Zeuzem, Vyacheslav Zhdan
BACKGROUND: Etrolizumab is a gut-targeted anti-β7 integrin monoclonal antibody. In a previous phase 2 induction study, etrolizumab significantly improved clinical remission versus placebo in patients with moderately to severely active ulcerative col
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49028f5b2bacad2d2fd85b64f3d13e76
https://lirias.kuleuven.be/handle/20.500.12942/720387
https://lirias.kuleuven.be/handle/20.500.12942/720387
Autor:
Guruprasad P. Aithal, Robert Herring, Hak-Myung Lee, Harry Sarles, Melissa Palmer, Muhammad Y. Sheikh, Philip N. Newsome, Parvez S. Mantry, Tarek Hassanein, Aasim Sheikh, Zeid Kayali, Bradley Freilich
Publikováno v:
Journal of Hepatology. 73:231-240
Background & Aims Volixibat is an inhibitor of the apical sodium-dependent bile acid transporter (ASBT) that has been hypothesized to improve non-alcoholic steatohepatitis (NASH) by blocking bile acid reuptake and stimulating hepatic bile acid produc
Autor:
Taddese Desta, Brent A. Neuschwander-Tetri, Magdy Elkhashab, Alaa Ahmad, Zeid Kayali, Douglas Denham, Eric Lawitz, Kris V. Kowdley, Vlad Ratziu, Jeffery DeGrauw, Aasim Sheikh, Bryan Goodwin, Nathalie Adda, Mary E. Rinella
Publikováno v:
Journal of hepatology. 76(3)
Background & Aims EDP-305 is an oral farnesoid X receptor (FXR) agonist under development for treating nonalcoholic steatohepatitis (NASH). The efficacy, safety, and tolerability of EDP-305 was evaluated in a Phase 2, randomized, double-blind, placeb
Autor:
Ilan Wapinski, Brian B. Borg, Naim Alkhouri, G. Mani Subramanian, Rajalakshmi Iyer, Anita Kohli, John E. Poulos, Bal R. Bhandari, Tarek Hassanein, Kris V. Kowdley, Aasim Sheikh, Mazen Noureddin, Zachary Goodman, Chuhan Chung, Andrew H. Beck, Keyur Patel, Ryan S Huss, Jen Chieh Chuang, Robert P. Myers, Guy Neff, Reem Ghalib, Atlas Investigators, Vincent Wai-Sun Wong, Catherine Jia, Mitchell L. Shiffman, Rohit Loomba, Magdy Elkhashab, Heidi Kabler, Murray B. Resnick, D. Ding, Nadege Gunn, Stephen H. Caldwell, Ziad Younes, Simone I. Strasser, Peter Ruane
Publikováno v:
Hepatology (Baltimore, Md.)References. 73(2)
Background and aims Advanced fibrosis attributable to NASH is a leading cause of end-stage liver disease. Approach and results In this phase 2b trial, 392 patients with bridging fibrosis or compensated cirrhosis (F3-F4) were randomized to receive pla
Autor:
Fernando Membreno, Giuseppe Morelli, Ray Thomason, Kalyan Ram Bhamidimarri, Dawn Torres, Andrew Scanga, Danielle Brandman, Guy W. Neff, Mark McKenzie, Stephen H. Caldwell, Kathleen E. Corey, Nadeem Anwar, Kimberly A. Brown, James Strobel, Sammy Saab, Thomas Amankonah, Bal R. Bhandari, Souvik Sarkar, Don C. Rockey, Miguel Á. Rodríguez, Mazen Noureddin, Edward Mena, Nikolaos Pyrsopoulos, Ayman Koteish, Gary A. Abrams, Andrew DeLemos, Richard Frederick, Bhaktasharan Patel, David T. Hagerty, Amy Stratton, Kathryn J. Lucas, Ethan M. Weinberg, Zeid Kayali, Anita Kohli, Marina Roytman, Kris V. Kowdley, Nicole Wedick, Brett E. Fortune, Michael P. Curry, Sofia Jakab, Kiran Bambha, Satinder Gill, Stevan A. Gonzalez, Nikunj Shah, Warren N. Schmidt, Jean L. Chan, Charles S. Landis, Bradley Freilich, Catherine Frenette, Hugo E. Vargas, Mary E. Rinella, Mohammad S. Siddiqui, Andrew P. Keaveny, George Therapondos, Elizabeth C. Verna, Ray Kim, James M. Robinson, David I. Bernstein, Marwan Ghabril, Reem Ghalib, John M. Vierling, Manal F. Abdelmalek, Paul J. Thuluvath, Jen-Jung Pan, Ravi Ravendhran, Amanda Wieland, Eric Lawitz, Justin Reynolds, Victor Ankoma-Sey, Mitchell L. Shiffman, Nyingi Kemmer, William M. Lee, Viviana Figueroa-Diaz, Douglas A. Simonetto, Jonathan Huang, Aasim Sheikh, Parvez S. Mantry, Harvey Tatum, Lance Stein
Publikováno v:
Journal of hepatology. 74(2)
Background & Aims Non-alcoholic steatohepatitis is a leading cause of end-stage liver disease. Hepatic steatosis and lipotoxicity cause chronic necroinflammation and direct hepatocellular injury resulting in cirrhosis, end-stage liver disease and hep
Autor:
Aasim Sheikh, C. Stephen Djedjos, Yanni Zhu, Natalie Bzowej, Robert P. Myers, Raj Vuppalanchi, Zobair M. Younossi, Kathryn Kersey, Mitchell L. Shiffman, Catherine Jia, Michael Trauner, Takeshi Okanoue, Naim Alkhouri, Nadege Gunn, Shiv Kumar Sarin, Anita Kohli, Georgia Li, Stellar, Stephen H. Caldwell, Manuel Romero-Gómez, Eric Lawitz, Quentin M. Anstee, Ziad Younes, G. Mani Subramanian, Zachary Goodman, Stephen A. Harrison, Vincent Wai-Sun Wong, Stellar Investigators, Marianne Camargo
Publikováno v:
Journal of Hepatology
Background & Aims Apoptosis signal-regulating kinase 1 (ASK1) plays a key role in hepatocyte injury, inflammation, and fibrosis in non-alcoholic steatohepatitis (NASH). We evaluated the safety and antifibrotic effect of selonsertib, a selective inhib