Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Aashish, Soni"'
Autor:
Fanghua Li, Emil Mladenov, Yanjie Sun, Aashish Soni, Martin Stuschke, Beate Timmermann, George Iliakis
Publikováno v:
Cells, Vol 12, Iss 11, p 1530 (2023)
Alt-EJ is an error-prone DNA double-strand break (DSBs) repair pathway coming to the fore when first-line repair pathways, c-NHEJ and HR, are defective or fail. It is thought to benefit from DNA end-resection—a process whereby 3′ single-stranded
Externí odkaz:
https://doaj.org/article/d417227a457c454ba99e032b1b532712
Publikováno v:
Cells, Vol 12, Iss 10, p 1387 (2023)
We have recently reported that in G2-phase cells (but not S-phase cells) sustaining low loads of DNA double-strand break (DSBs), ATM and ATR regulate the G2-checkpoint epistatically, with ATR at the output-node, interfacing with the cell cycle throug
Externí odkaz:
https://doaj.org/article/d3f920a1217a469aafc42b8b5cab2c63
Autor:
Aggeliki Nikolakopoulou, Aashish Soni, Martha Habibi, Pantelis Karaiskos, Gabriel Pantelias, Georgia I. Terzoudi, George Iliakis
Publikováno v:
Frontiers in Public Health, Vol 9 (2021)
While technological advances in radiation oncology have led to a more precise delivery of radiation dose and a decreased risk of side effects, there is still a need to better understand the mechanisms underlying DNA damage response (DDR) at the DNA a
Externí odkaz:
https://doaj.org/article/52a5985618e9403fb7780f9678497bd3
Autor:
Huaping Xiao, Fanghua Li, Emil Mladenov, Aashish Soni, Veronika Mladenova, Bing Pan, Rositsa Dueva, Martin Stuschke, Beate Timmermann, George Iliakis
Publikováno v:
Cells, Vol 11, Iss 13, p 2099 (2022)
The load of DNA double-strand breaks (DSBs) induced in the genome of higher eukaryotes by different doses of ionizing radiation (IR) is a key determinant of DSB repair pathway choice, with homologous recombination (HR) and ATR substantially gaining g
Externí odkaz:
https://doaj.org/article/177e341c6d6540558bf99266ef49665a
Autor:
Iliakis, Fanghua Li, Emil Mladenov, Yanjie Sun, Aashish Soni, Martin Stuschke, Beate Timmermann, George
Publikováno v:
Cells; Volume 12; Issue 11; Pages: 1530
Alt-EJ is an error-prone DNA double-strand break (DSBs) repair pathway coming to the fore when first-line repair pathways, c-NHEJ and HR, are defective or fail. It is thought to benefit from DNA end-resection—a process whereby 3′ single-stranded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::fa9e2cc35bb5001f2f80d4f6de76d44f
Autor:
George E. Iliakis, Dian Wang, Richard L. Piekarz, Beverly A. Teicher, C. Norman Coleman, Mansoor Ahmed, Mohammad Sharif Mortoga Hasan, Shipra Chaudhary, Lisa Marie Krieger, Martha Grabos, You Wang, Fanghua Li, Aashish Soni
BMN673 compromises repair of IR induced DSBs as measured by gamma H2AX foci fromation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e9ef936ace0566a188ae959021b832b
https://doi.org/10.1158/1535-7163.22505142
https://doi.org/10.1158/1535-7163.22505142
Autor:
George E. Iliakis, Dian Wang, Richard L. Piekarz, Beverly A. Teicher, C. Norman Coleman, Mansoor Ahmed, Mohammad Sharif Mortoga Hasan, Shipra Chaudhary, Lisa Marie Krieger, Martha Grabos, You Wang, Fanghua Li, Aashish Soni
Table S1: Dose Modification Factor at 10% survival in different cell lines. Table S2: List of primary and secondary antibodies. Table S3: Cytotoxicity of different inhibitors in un-irradiated CHO cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b06a0cdca138f63a8bd84c47fc55eab
https://doi.org/10.1158/1535-7163.22505127.v1
https://doi.org/10.1158/1535-7163.22505127.v1
Autor:
George E. Iliakis, Dian Wang, Richard L. Piekarz, Beverly A. Teicher, C. Norman Coleman, Mansoor Ahmed, Mohammad Sharif Mortoga Hasan, Shipra Chaudhary, Lisa Marie Krieger, Martha Grabos, You Wang, Fanghua Li, Aashish Soni
Parp inhibitors (Parpi) are commonly used as single agents for the management of tumors with homologous recombination repair (HRR) deficiencies, but combination with radiotherapy (RT) is not widely considered due to the modest radiosensitization typi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c9e1192da83a04e62b5b3a9ad80489c
https://doi.org/10.1158/1535-7163.c.6537963.v1
https://doi.org/10.1158/1535-7163.c.6537963.v1
Autor:
Fanghua Li, Emil Mladenov, Anna Broich, Aashish Soni, Martin Stuschke, Beate Timmermann, George Iliakis
Alt-EJ is an error-prone DNA double-strand break (DSBs) repair pathway coming to the fore when first-line repair pathways, c-NHEJ and HR, are defective or fail. It is thought to depend on DNA end-resection: a process whereby 3’ single-stranded DNA-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dbfec8a458030aea8a56c735f0de360
https://doi.org/10.21203/rs.3.rs-2094165/v1
https://doi.org/10.21203/rs.3.rs-2094165/v1
Publikováno v:
Cancers. 14(22)
OA Förderung 2022 BMN673 is a relatively new PARP inhibitor (PARPi) that exhibits superior efficacy in vitro compared to olaparib and other clinically relevant PARPi. BMN673, similar to most clinical PARPi, inhibits the catalytic activities of PARP-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aba66910a8b26e680da8df2ecc3be8a
https://pubmed.ncbi.nlm.nih.gov/36428712
https://pubmed.ncbi.nlm.nih.gov/36428712