Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Aarti R Shah"'
Autor:
Richard J Perrin, Rebecca Craig-Schapiro, James P Malone, Aarti R Shah, Petra Gilmore, Alan E Davis, Catherine M Roe, Elaine R Peskind, Ge Li, Douglas R Galasko, Christopher M Clark, Joseph F Quinn, Jeffrey A Kaye, John C Morris, David M Holtzman, R Reid Townsend, Anne M Fagan
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16032 (2011)
BackgroundIdeally, disease modifying therapies for Alzheimer disease (AD) will be applied during the 'preclinical' stage (pathology present with cognition intact) before severe neuronal damage occurs, or upon recognizing very mild cognitive impairmen
Externí odkaz:
https://doaj.org/article/14913627f3684daeb666751f635a0bc9
Autor:
Carlos Cruchaga, John S K Kauwe, Kevin Mayo, Noah Spiegel, Sarah Bertelsen, Petra Nowotny, Aarti R Shah, Richard Abraham, Paul Hollingworth, Denise Harold, Michael M Owen, Julie Williams, Simon Lovestone, Elaine R Peskind, Ge Li, James B Leverenz, Douglas Galasko, Alzheimer's Disease Neuroimaging Initiative, John C Morris, Anne M Fagan, David M Holtzman, Alison M Goate
Publikováno v:
PLoS Genetics, Vol 6, Iss 9, p e1001101 (2010)
Alzheimer's Disease (AD) is a complex and multifactorial disease. While large genome-wide association studies have had some success in identifying novel genetic risk factors for AD, case-control studies are less likely to uncover genetic factors that
Externí odkaz:
https://doaj.org/article/5639de89f57e446096241aa0086e24a8
Autor:
Ann M. Stowe, Tracy L. Adair-Kirk, Ernesto R. Gonzales, Ronald S. Perez, Aarti R. Shah, Tae S. Park, Jeffrey M. Gidday
Publikováno v:
Neurobiology of Disease, Vol 35, Iss 1, Pp 82-90 (2009)
Neutrophil elastase (NE) degrades basal lamina and extracellular matrix molecules, and recruits leukocytes during inflammation; however, a basic understanding of the role of NE in stroke pathology is lacking. We measured an increased number of extrav
Externí odkaz:
https://doaj.org/article/4458421316954e719f21211bbeee53dd
Autor:
Byung Hee Han, Anselm D'Costa, Stephen A. Back, Maia Parsadanian, Shilen Patel, Aarti R. Shah, Jeffrey M. Gidday, Anu Srinivasan, Mohanish Deshmukh, David M. Holtzman
Publikováno v:
Neurobiology of Disease, Vol 7, Iss 1, Pp 38-53 (2000)
Hypoxic–ischemic (H-I) injury to the brain in the perinatal period often leads to significant long-term neurological deficits. In a model of neonatal H-I injury in postnatal day 7 rats, our previous data have shown that cell death with features of
Externí odkaz:
https://doaj.org/article/b996d02aa3004a37972c0ee73143f5ca
Autor:
Jacob B. Ruden, Kevin L. Quick, Ernesto R. Gonzales, Aarti R. Shah, T. S. Park, Nan Kennedy, Laura L. Dugan, Jeffrey M. Gidday
Publikováno v:
Frontiers in Neurology
Frontiers in Neurology, Vol 10 (2019)
Frontiers in Neurology, Vol 10 (2019)
Background: Asphyxia is the most common cause of brain damage in newborns. Substantial evidence indicates that leukocyte recruitment in the cerebral vasculature during asphyxia contributes to this damage. We tested the hypothesis that superoxide radi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75147ecd6d2f8213e55feb25a37d6fe7
https://doi.org/10.3389/fneur.2019.00447
https://doi.org/10.3389/fneur.2019.00447
Autor:
Lei Wang, Mirza Faisal Beg, Anne M. Fagan, John G. Csernansky, David M. Holtzman, Aarti R. Shah, John C. Morris
Publikováno v:
Alzheimer Disease & Associated Disorders. 26:314-321
Objective Biomarkers are needed to improve the sensitivity and accuracy of diagnosis as well as prognosis in individuals with early Alzheimer disease (AD). Measures of brain structure and disease-related proteins in the cerebrospinal fluid (CSF) have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8bf4bb8e890d19f68c96ee9b45f95d5
https://doi.org/10.1097/wad.0b013e31823c0cf4
https://doi.org/10.1097/wad.0b013e31823c0cf4
Autor:
Aarti R. Shah, Daniel S. Marcus, John C. Morris, Denise Head, David M. Holtzman, Mark A. Mintun, Anne M. Fagan
Publikováno v:
Annals of Neurology. 65:176-183
For therapies for Alzheimer's disease (AD) to have the greatest impact, it will likely be necessary to treat individuals in the "preclinical" (presymptomatic) stage. Fluid and neuroimaging measures are being explored as possible biomarkers of AD path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d92b1fe3ad04e61c20ba47801ee08b1a
https://doi.org/10.1002/ana.21559
https://doi.org/10.1002/ana.21559
Autor:
Anne M. Fagan, Claudia Muñoz, Aaron P. Schultz, Martha Muniz, Gloria María Gallego García, Francisco Lopera, Kewei Chen, Pradeep Thiyyagura, Hillary Protas, Bradford C. Dickerson, Dora Ramirez, Pierre N. Tariot, Margarita Giraldo, Eric M. Reiman, Michael Brickhouse, Reisa A. Sperling, Aarti R. Shah, Jessica B. Langbaum, Yakeel T. Quiroz, Adam S. Fleisher, Natalia Acosta-Baena, Victoria Tirado, Joseph F. Arboleda-Velasquez
Brain imaging and fluid biomarkers are characterized in children at risk for autosomal dominant Alzheimer disease (ADAD).To characterize and compare structural magnetic resonance imaging (MRI), resting-state and task-dependent functional MRI, and pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395d5ebcbd1a588f45fe512ee32355fe
https://europepmc.org/articles/PMC4625544/
https://europepmc.org/articles/PMC4625544/
Autor:
Pradeep Thiyyagura, Anne M. Fagan, Madelyn Gutierrez, Kewei Chen, Yakeel T. Quiroz, Gloria María Gallego García, Pierre N. Tariot, Hillary Protas, Claudia Muñoz, Margarita Giraldo, Victoria Tirado, Lina Velilla, Sehily Y. Jaimes, Reisa A. Sperling, Francisco Lopera, Aarti R. Shah, Eric M. Reiman, Marisol Londono, Auttawut Roontiva, Jessica B. Langbaum
Publikováno v:
Alzheimer's & Dementia. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f768a0a95470e5f08f63856f23fa0763
https://doi.org/10.1016/j.jalz.2015.08.098
https://doi.org/10.1016/j.jalz.2015.08.098
Publikováno v:
Experimental Eye Research. 74:493-501
The formation of reactive oxygen species (ROS) may be important in the pathogenesis of microvascular dysfunction and injury in ischemic retinopathies. The authors hypothesized that retinal endothelial cells can generate injurious levels of superoxide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1c5224361f5d81805d4be63ecbd3ef
https://doi.org/10.1006/exer.2001.1156
https://doi.org/10.1006/exer.2001.1156