Výsledky vyhledávání - "Aarti Juvekar"

Design, synthesis and biological evaluation of novel pyrazolochalcones as potential modulators of PI3K/Akt/mTOR pathway and inducers of apoptosis in breast cancer cells

Autor: Garikapati Koteswara Rao, Ahmed Kamal, Sunitha Rani Routhu, Aarti Juvekar, Vangala Santhosh Reddy, Immadi Veena, Shailesh Jadhav, Madan Barkume, Nibedita Patel, Anver Basha Shaik, Irfan Khan, Kunta Chandra Shekar, C. Ganesh Kumar, Manika Pal-Bhadra, G. Bharath Kumar, Jyoti Kode

Publikováno v: European journal of medicinal chemistry. 139

Cancer has been established as the "Emperor of all maladies". In recent years, medicinal chemistry has focused on identifying novel anti-cancer compounds; though discovery of these compounds appears to be a herculean task. In present study, we synthe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89764c79ff896ed2390a72a33e3a7fc1
https://pubmed.ncbi.nlm.nih.gov/28803046

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Establishment of a Tongue Squamous Cell Carcinoma Cell Line from Indian Gutka Chewer

Autor: Asawari Patil, Jyoti J. Kayal, Shubhada Kane, Aarti Juvekar, Manoj B. Mahimkar, Abhijeet Nikam, Pradnya Kowtal, Madan Barkume, Tejas T. Patil

Publikováno v: Journal of Oral Oncology. 2014:1-9

CD cell line has been established from a poorly differentiated squamous cell carcinoma of tongue. This is a first ever cell line established from an Indian gutka chewer. Cell line was characterized for morphology, ultrastructure, doubling time, expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd3459ce0d4005ec90195bc6c261a537
https://doi.org/10.1155/2014/286013

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Design and synthesis of (S)- and (R)-enantiomers of [4-(2-hydroxy-1-phenylethylimino)pent-2-ol]dimethyltin(iv) and 2,2-dimethyl-4-phenyl-1,3,2-oxazastannolidine: in vitro antitumor activity against human tumor cell lines and in vivo assay of (S)-enantiomers

Autor: Sartaj Tabassum, Fatima Sayeed, Farukh Arjmand, Shazia Parveen, Surekha M. Zingde, Aarti Juvekar

Publikováno v: Dalton Trans.. 42:3390-3401

New dimethyltin derived antitumor drug candidates (S)- and (R)-[4-(2-hydroxy-1-phenylethylimino)pent-2-ol]dimethyltin(iv), 1 and (S)- and (R)-[2,2-dimethyl-4-phenyl-1,3,2-oxazastannolidine], 2 derived from (R)- and (S)-enantiomers of [4-(2-hydroxy-1-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a17d98907a96ab5f0549df6438925a39
https://doi.org/10.1039/c2dt32155f

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Carbohydrate-conjugate heterobimetallic complexes: synthesis, DNA binding studies, artificial nuclease activity and in vitro cytotoxicity

Autor: Surekha M. Zingde, Farukh Arjmand, Sartaj Tabassum, Mubashira Aziz, Aarti Juvekar, Rais Ahmad Khan

Publikováno v: Carbohydrate Research. 346:2886-2895

New carbohydrate-conjugated heterobimetallic complexes [C 32 H 62 N 10 O 8 NiSn 2 Cl 4 ]Cl 2 (1) and [C 32 H 62 N 10 O 8 CuSn 2 Cl 4 ]Cl 2 ( 2) were synthesized and characterized by spectroscopic (IR, 1 H, 13 C, and 119 Sn NMR, EPR, UV–vis, ESI-MS)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d494d6239a8855b1271281899ff26ae
https://doi.org/10.1016/j.carres.2011.10.010

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Synthesis of Aryl-Substituted Naphthalene-Linked Pyrrolobenzodiazepine Conjugates as Potential Anticancer Agents with Apoptosis-Inducing Ability

Autor: Y. V. V. Srikanth, Aarti Juvekar, M. Janaki Ramaiah, Manika Pal-Bhadra, G. Bharath Kumar, Surekha M. Zingde, V. Santosh Reddy, Indira Bag, Ahmed Kamal, Rajender, Subrata Sen, M. Kashi Reddy, S.N.C.V.L. Pushpavalli

Publikováno v: ChemMedChem. 6:1665-1679

A library of new aryl-substituted naphthalene C8-linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates with various linker architectures were designed, synthesized, and evaluated for their anticancer activity against a panel of 11 human cancer ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec6efdc90c3689565e6284f78307f152
https://doi.org/10.1002/cmdc.201100207

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Synthesis, anticancer activity and apoptosis inducing ability of anthranilamide-PBD conjugates

Autor: Ahmed Kamal, Farheen Sultana, D. Dastagiri, Subrata Sen, M. Janaki Ramaiah, Aarti Juvekar, Surekha M. Zingde, A. Viswanath, J. Surendranadha Reddy, E. Vijaya Bharathi, Manika Pal-Bhadra, S.N.C.V.L. Pushpavalli

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 20:3310-3313

A series of novel anthranilamide linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates were prepared and evaluated for their anticancer activity. The effects of three promising PBD conjugates on cell cycle of cancerous cell line A375 were investigated.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa1c07b29a5866f2a1af663590e8efb
https://doi.org/10.1016/j.bmcl.2010.04.037

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Design, Synthesis and Evaluation of Novel 1-(Substituted Acetyl)-4-(10-Bromo-8-Chloro-5,6-Dihydro-11H-Benzo[5,6]Cyclohepta[1,2-B]Pyridine-11-Ylidene)piperidines as Antitumor Agents and Farnesyl Protein Transferase Inhibitors

Autor: PS Gatne, Premlata K. Ambre, Aarti Juvekar, C.L. Viswanathan

Publikováno v: Indian Journal of Pharmaceutical Sciences

Eight novel 1-(substituted acetyl)-4-(10-bromo-8-chloro-5,6-dihydro-11H-benzo[5,6] cyclohepta [1,2-b] pyridine-11-ylidene)piperidines were designed by incorporating zinc binding groups to enhance activity. The designed molecules were synthesized and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1560061c7801ab864719f2622c668a93
http://europepmc.org/articles/PMC3116320

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Synthesis, DNA-binding ability and evaluation of antitumour activity of triazolo[1,2,4]benzothiadiazine linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates

Autor: Y. V. V. Srikanth, Nisha Kurian, Subrata Sen, Aarti Juvekar, Surekha M. Zingde, K. Srinivasa Reddy, Ahmed Kamal, M. Naseer A. Khan

Publikováno v: Bioorganic & Medicinal Chemistry. 16:7804-7810

A series of triazolobenzothiadiazine-pyrrolobenzodiazepine conjugates linked through different alkane spacers have been prepared. These compounds have exhibited significant cytotoxicity against most of the cell lines examined. Compound 5a displays GI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8335404f90202cafb2548bf7de91d7e
https://doi.org/10.1016/j.bmc.2008.06.056

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Phosphonate-linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: Synthesis, DNA-binding affinity and cytotoxicity

Autor: Aarti Juvekar, P. Praveen Kumar, Ahmed Kamal, O. Srinivas, B. N. Seshadri, M. Shiva Kumar, Nisha Kurian, Subrata Sen, Surekha M. Zingde

Publikováno v: Bioorganic & Medicinal Chemistry. 16:3895-3906

Pyrrolobenzodiazepine-diethylphosphonate conjugates have been designed and synthesized that link through two different types of spacers that are simple alkane chain and also a piperazine moiety side-armed with the alkane chains. These pyrrolobenzodia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1cf4a4586adc7230bd7162897443b9f
https://doi.org/10.1016/j.bmc.2008.01.040

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